The incidence of neural tube defects in Norway and the Arkhangelskaja Oblast in Russia and the association with maternal age

Petrova, Jelena G.; Vaktskjold, Arild

doi:10.1080/00016340902898008

Cited by 20 publications

(11 citation statements)

References 26 publications

(50 reference statements)

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“…This study showed that there was no significant difference between mothers’ ages and NTDs, whereas maternal age of over 40 years in Texas (9) and maternal age of over 30 years in Russia (13) were associated with NTDs. In Turkey (14) and Italy (4), significant association between mothers’ ages and NTDs was found.…”

Section: Discussionmentioning

confidence: 67%

Risk Factors of Neural Tube Defects in Northern Iran

Golalipour

Qorbani

Mirfazeli

et al. 2014

Iran Red Crescent Med J

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Background:Neural tube defects (NTDs) including spina bifida and anencephaly are the second most common birth defects with 2.8 per 1000 births in northern Iran.Objectives:This study was conducted to determine the risk factors of neural tube defects in Gorgan, north of Iran.Patients and Methods:This hospital-based, case-control study was carried out on all NTD-affected pregnancies (n = 59) during February 2007 - August 2010, and 160 healthy pregnancies were selected via convenient sampling method in three hospitals in Gorgan, north of Iran. Risk factors including maternal body mass index (BMI), season of birth, gender of the newborn, mother’s age, ethnicity, consanguineous marriage, folic acid consumption, nutrition, habitat, and education, were assessed through interviews with mothers. Univariate and multivariate logistic regression analyses were used to estimate the risks by odds ratios (ORs) and 95% confidence intervals.Results:The multivariate analysis showed that maternal BMI (normal/underweight OR: 0.23, overweight/underweight OR: 0.15, obese/underweight OR: 0.13) and maternal ethnicity (Fars/Sistani OR: 3.49) and maternal nutrition (good/poor OR: 0.46) were significantly correlated with NTDs in the newborns.Conclusions:This study showed that maternal ethnicity, insufficient nutrition, and BMI, were the main risk factors of NTDs in northern Iran.

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Section: Discussionmentioning

confidence: 67%

Risk Factors of Neural Tube Defects in Northern Iran

Golalipour

Qorbani

Mirfazeli

et al. 2014

Iran Red Crescent Med J

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“…Some studies report that maternal tea consumption during early pregnancy increases the risk of NTDs (Ye et al, 2011;Correa et al, 2000;Fedrick, 1974), whereas another study does not find an association (Yazdy et al, 2012). Petrova and Vieira propose that maternal age is correlated with the risk of infant NTDs (Petrova and Vaktskjold, 2009;Vieira and Castillo Taucher, 2005). There is no consensus regarding the effect of paternal age on NTD risk; it remains to be confirmed whether younger or older fathers increase the risk of producing an infant with NTDs, or whether this risk https://doi.org/10.1016/j.ijdevneu.2019.09.006 Received 30 May 2019; Received in revised form 22 September 2019; Accepted 24 September 2019 differs depending on the type of NTDs.…”

Section: Introductionmentioning

confidence: 99%

Maternal, paternal, and neonatal risk factors for neural tube defects: A systematic review and meta‐analysis

Jia

Wei

et al. 2019

Intl J of Devlp Neuroscience

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Objective Neural tube defects [NTDs] are severe congenital anomalies. The etiology of NTDs is not fully known, and studies on the potential risk factors of NTDs present inconsistent results. Thus, we conducted a systematic review and meta‐analysis to investigate the maternal, paternal, and neonatal risk factors for NTDs. Study design We systematically reviewed relative original studies published through October 6, 2018 available in Pubmed, Embase and the Cochrane Library without restrictions for language. The selected studies measured maternal, paternal, and neonatal risk factors and examined their associations with NTDs. A meta‐analysis, including subgroup analysis and sensitivity analysis, was conducted to estimate the pooled effect measures. Two reviewers independently extracted data using a predesigned data collection form. Results Forty‐five studies were eligible for inclusion in the meta‐analysis, and twelve potential risk factors were analyzed. The factors that were associated with NTDs risk included stressful life events [odds ratio [OR],1.61; 95% confidence interval [CI], 1.24―2.08; p < 0.001; I2 = 59.2%], low maternal education level [OR, 1.42; 95% CI, 1.19―1.70; p < 0.001; I2 = 47.7%], pregestational diabetes [OR, 2.24; 95% CI, 1.21―4.12; p < 0.010; I2 = 56.3%], low paternal age [OR, 1.41; 95% CI, 1.10―1.81; p = 0.007; I2 = 0.0%], low birth weight [OR, 5.53; 95% CI, 1.95―15.70; p = 0.001; I2 = 98.5%], and neonatal female gender [OR, 1.54; 95% CI, 1.10―2.14; p = 0.012; I2 = 67.8%]. Conclusion Stressful life events, pregestational diabetes, low birth weight, and neonatal female gender are risk factors associated with NTDs. Low maternal education level and low paternal age are factors that are moderately associated with NTDs. Further cohort studies are required to verify the factors associated with NTDs and control the risk of this severe birth defect.

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“…This tendency was also observed per live birth, although it was not statistically significant. Petrova and Vaktskjold36 reported an inverse association between maternal age and the prevalence of neural tube defects. This tendency would be partly explained by the lower folic acid status resulting from poorer nutrition or lower periconceptional folic acid supplementation rates 16,36.…”

Section: Discussionmentioning

confidence: 97%

“…Petrova and Vaktskjold36 reported an inverse association between maternal age and the prevalence of neural tube defects. This tendency would be partly explained by the lower folic acid status resulting from poorer nutrition or lower periconceptional folic acid supplementation rates 16,36. It was also pointed out that in Japan younger women did not recognize the importance of folic acid intake to prevent neural tube defects as strongly as older women, and they were apt to take less folic acid, regardless of the precautions taken by the Ministry of Health, Labor and Welfare of Japan 38.…”

Section: Discussionmentioning

confidence: 97%

Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004–2010

Ooki¹

2013

IJWH

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BackgroundOlder mothers are becoming more common in Japan. One reason for this is the widespread use of assisted reproductive technology (ART). This study assesses the relationship between maternal age and the risk of birth defects after ART.MethodsNationwide data on ART between 2004 and 2010 in Japan were analyzed. Diseases that were classified as code Q00-Q99 (ie, congenital malformations, deformations, and chromosomal abnormalities) in the International Classification of Diseases, tenth edition, were selected. There were 219,185 pregnancies and 153,791 live births in total ART. Of these, 1943 abortions, stillbirths, or live births with birth defects were recorded. Percentage of multiple birth defects in total birth defects, the prevalence, crude relative risk and 95% confidence interval per 10,000 pregnancies and per 10,000 live births were analyzed according to the maternal age class (ie, 25–29, 30–34 (reference), 35–39, and 40+ years).ResultsMultiple birth defects were observed among 14% of the 25–29 year old class, and 8% among other classes when chromosomal abnormalities were excluded. The prevalence of chromosomal abnormalities per pregnancy and per live birth became significantly and rapidly higher in mothers in the age classes of 30–35 and 40+ years. Nonchromosomal birth defects per pregnancy decreased linearly with advanced maternal age, while the number of nonchromosomal birth defects per live birth formed a gradual U-shaped distribution. The prevalence per pregnancy of congenital malformations of the nervous system was significantly lower with advanced maternal age. The relative risk per live birth was significant regarding congenital malformations of the circulatory system for a maternal age of 40+ years. Some other significant associations between maternal age and birth defects were observed.ConclusionMaternal age is associated with several birth defects; however, older maternal age in itself does not produce noticeable extra risk for nonchromosomal birth defects overall.

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The incidence of neural tube defects in Norway and the Arkhangelskaja Oblast in Russia and the association with maternal age

Cited by 20 publications

References 26 publications

Risk Factors of Neural Tube Defects in Northern Iran

Risk Factors of Neural Tube Defects in Northern Iran

Maternal, paternal, and neonatal risk factors for neural tube defects: A systematic review and meta‐analysis

Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004–2010

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The incidence of neural tube defects in Norway and the Arkhangelskaja Oblast in Russia and the association with maternal age

Cited by 20 publications

References 26 publications

Risk Factors of Neural Tube Defects in Northern Iran

Risk Factors of Neural Tube Defects in Northern Iran

Maternal, paternal, and neonatal risk factors for neural tube defects: A systematic review and meta‐analysis

Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004&ndash;2010

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Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004–2010