The incidence of mucinous appendiceal malignancies: a population-based study

Heuvel, M. G. W. van den; Lemmens, Valery; Verhoeven, Rob H.A.; Hingh, Ignace H. J. T. de

doi:10.1007/s00384-013-1714-9

Cited by 46 publications

(25 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, age at diagnosis has decreased over the same time period . A similar pattern of increase in incidence and decrease in age at diagnosis was observed in a large registry study from the Netherlands spanning 1980–2010 . The trends over time in incidence, demographics, type of surgery, and survival of patients with AMN were analyzed using the Surveillance, Epidemiology, and End Results Program database .…”

Section: Epidemiology and Characteristicsmentioning

confidence: 57%

Appendiceal Mucinous Neoplasms: Diagnosis and Management

et al. 2017

View full text Add to dashboard Cite

Objective Appendiceal mucinous neoplasms (AMNs) are a rare and heterogeneous disease for which clinical management is challenging. We aim to review the literature regarding modalities of treatment to guide the management of AMNs. Methods and Review Criteria We conducted a PubMed search in February 2016 for English‐language publications, using the terms “appendiceal,” “appendix,” “carcinoma,” “cancer,” “mucinous,” “treatment,” “genes,” “target,” “genomic,” and terms listed in the articles' subheadings. Published reports and abstracts from the American Society of Clinical Oncology meetings were also searched. Results In this review, we summarize current data and controversies in AMN classification, clinical presentation, molecular alterations, treatment outcomes with regard to cytoreductive surgery, hyperthermic intraperitoneal chemotherapy (HIPEC), and the role of systemic chemotherapy. Conclusion Appendiceal mucinous neoplasms are a heterogeneous group of tumors with a rising incidence. Treatment is based on stage and histology. Low‐grade tumors are treated surgically with resection of the primary site in early stage disease, or peritoneal debulking and HIPEC in patients with advanced stage disease. Treatment of high‐grade tumors requires further prospective trials, and options include debulking surgery and HIPEC with or without preoperative chemotherapy. Trials evaluating novel therapies based on the molecular profiling of AMN tumors are needed to evaluate therapeutic options in patients who are not surgical candidates. Implications for Practice This review provides a reference to guide gastroenterologists, pathologists, surgeons, and oncologists in the management of appendiceal mucinous neoplasms (AMNs), a rare and heterogeneous disease with no consensus on histologic classification or guidelines for treatment algorithms. This review summarizes all AMN classifications and proposes a treatment algorithm based on stage and histology of disease.

show abstract

Section: Epidemiology and Characteristicsmentioning

confidence: 57%

Appendiceal Mucinous Neoplasms: Diagnosis and Management

et al. 2017

View full text Add to dashboard Cite

show abstract

“…20 The changing incidence of AMN may be related to improvement in detection and recognition of this disease entity. The rise in AMN incidence also parallels a rising incidence of colorectal cancer in young adults during a similar time frame in the United States.…”

Section: Discussionmentioning

confidence: 99%

“…This has led to the adoption of this approach as the standard therapy for advanced AMN disease. [14][15][16][17] Although natural history and prognosis of AMN has been studied in single-institution studies, these studies were all rather small (N = 50 to 164) [18][19][20][21] and of limited generalizability except for 1 multicenter retrospective report (N = 2298). 15 This knowledge gap can be addressed through population-based studies that rely on national cancer surveillance data.…”

mentioning

confidence: 98%

Incidence and Survival of Appendiceal Mucinous Neoplasms

Shaib

Goodman²,

Chen

et al. 2017

American Journal of Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…7 Other studies have found the incidence of appendiceal adenocarcinoma to be approximately 0.15 to 0.8 per 100 000, occurring in adults of any age with a peak incidence generally in the sixth decade. 8,[28][29][30] Mucinous appendiceal neoplasms without infiltrative invasion…”

Section: Introductionmentioning

confidence: 99%

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei

Carr¹,

et al. 2017

View full text Add to dashboard Cite

The vermiform appendix is the primary site of several distinctive benign and malignant neoplasms. Some can produce the clinical syndrome of pseudomyxoma peritonei (PMP). A consensus on their terminology was reached by an international panel of pathologists and clinicians working under the auspices of the Peritoneal Surface Oncology Group International (PSOGI), and this review discusses the application of the PSOGI classification to routine reporting. We discuss diagnosis and differential diagnosis together with implications for patient management, covering low-grade appendiceal mucinous neoplasms, high-grade appendiceal mucinous neoplasms, serrated polyps, adenomas and adenocarcinomas. We do not cover goblet cell tumours or neuroendocrine neoplasms in this paper.

show abstract

The incidence of mucinous appendiceal malignancies: a population-based study

Abstract: The reported incidence of mucinous adenocarcinomas of the appendix shows an increasing trend. This is probably mainly explained by the increased awareness of this tumour and its relation with PMP, and better registration of this specific diagnosis.

Cited by 46 publications

References 10 publications

Appendiceal Mucinous Neoplasms: Diagnosis and Management

Appendiceal Mucinous Neoplasms: Diagnosis and Management

Incidence and Survival of Appendiceal Mucinous Neoplasms

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei

Contact Info

Product

Resources

About