The incidence of motor nueron disease in Scotland

Abstract

Between 1989 and 1998, 1226 cases of ALS/MND were identified in Scotland, with mean age of onset 65.2 (SD 11.9) years for men and 67.2 (SD 11.0) for women. Annual standardized incidence was 2.40 per 100,000 (95% CI 2.22-2.58). Using capture recapture methods we confirm a high level of case ascertainment for each year of study. Incidence and ascertainment of ALS has remained stable in a large population over a prolonged period of time. Large population-based databases can be used to test aetiological hypotheses.

Amyotrophic lateral sclerosis: A higher than expected incidence in people over 80 years of age

“…The percentage of bulbar-onset patients is also most common than the reported in other studies 2,3,11,12,14 . As bulbar-onset ALS may be more common in the oldest age groups, this difference may be explained by the higher proportion of elderly patients in our population.…”

“…Only two previous studies have found a proportion of cases of people over 80 years above 10% 2,24 . For example, a recent study in the Limousin region in France found higher incidences in the oldest age groups, where ALS incidence showed a progressive rise with age culminating in a large peak between 65…”

“…Prospective, population-based methodology has been shown to be useful in defining clinical characteristics and prognostic indicators. Reported incidence rates are remarkably uniform across all registries among Caucasian populations, ranging from 1.7 to 2.3 cases per 100 000 person-years [1][2][3] .…”

“…However, the decrease in incidence rates in the population over 75 years of age might in fact still be a result of under-ascertainment. Most population based studies show a peak of incidence in the 65-75 age-group 15 , only in two studies incidence rates are maintained in the age-group over 80 years 2,24 .…”

Uso de simbiótico no tratamento de pacientes obstipados com esclerose lateral amiotrófica

“…Os critérios diagnósticos utilizados permitem classificar a ELA em quatro níveis: suspeita, possível, provável e definitiva 12 . A ELA tem uma incidência mundial em torno de 1,0 a 2,5 casos/100.000 habitantes 13 , aumentando para 7,5 casos/100.000 habitantes na população acima dos 80 anos 14 . Algumas peculiaridades descritas na literatura despertam interesse quanto à alta incidência verificada na ilha de Guam e na Nova Guiné 15,16 .…”