The Incidence of Metabolic Syndrome and the Most Powerful Components as Predictors of Metabolic Syndrome in Central Iran: A 10-Year Follow-Up in a Cohort Study

Sarebanhassanabadi, Mohammadtaghi; Mirhosseini, Seyed Jalil; Mirzaei, Masoud; Namayandeh, Seyedeh Mahdieh; Soltani, Mohammad Hossein; Pedarzadeh, Ali; Baramesipour, Zahra; Faraji, Reza; Salehi‐Abargouei, Amin

doi:10.5812/ircmj.14934

Cited by 11 publications

(8 citation statements)

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“…Regarding to sex difference in the MetS incidence, our study showed that the MetS incidence in women was higher than that in men, in line with previous studies [21,25]. One study in Iran reported the reverse nding that the MetS incidence in men was higher than in women [27].…”

Section: Discussionsupporting

confidence: 91%

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Incidence and prediction nomogram for metabolic syndrome in a middle-aged Vietnamese population: a 5-year follow-up study

et al. 2021

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Purpose We aimed to determine the incidence and prediction nomogram for new-onset metabolic syndrome (MetS) in a middle-aged Vietnamese population.Methods A population-based prospective study was conducted in 1150 participants aged 40-64 years without MetS at baseline and followed-up for 5 years. Data on lifestyle factors, socioeconomic status, family diabetes history, and anthropometric measures were collected. MetS incidence was estimated in general population and subgroup of age, gender, and MetS components. A Cox proportional hazards regression was used to estimate hazard ratios (HRs) with 95% con dence intervals (CI) for MetS. A prediction nomogram was developed and checked for discrimination and calibration.Results During median follow-up of 5.14 years, the accumulate MetS incidence rate was 23.4% (95% CI: 22.2-24.7). The annual incidence rate (95%CI) was 52.9 (46.7-60.1) per 1000 person-years in general population and higher in women [56.6 (48.7-65.9)] than men [46.5 (36.9-59.3)]. The HRs (95% CI) for developing MetS were gender [females vs males: 2.04 (1.26-3.29)], advanced age [1.02 (1.01-1.04) per one year], waist circumference [1.08 (1.06-1.10) per one cm] and other obesity-related traits, and systolic blood pressure [1.02 (1.01-1.03) per one mmHg]. The prediction nomogram for MetS had a good discrimination (C-statistics = 0.742) and t calibration (mean absolute error = 0.009) with a positive net bene t in the predicted probability thresholds between 0.13 and 0.70. ConclusionsThe study is the rst to indicate an alarmingly high incidence of MetS in a middle-aged population in Vietnam. The nomogram with simply applicable variables would be useful to qualify individual risk of developing MetS.

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Section: Discussionsupporting

confidence: 91%

“…The current MetS incidence was relatively higher compared to a study in Japan with higher cut-off of WC criteria in both men and women [24]. Conversely, the incidence of MetS in current study was lower in Iran [25].…”

Section: Discussioncontrasting

confidence: 80%

Incidence and prediction nomogram for metabolic syndrome in a middle-aged Vietnamese population: a 5-year follow-up study

et al. 2021

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“…The cumulative 10-year incidence of MetS was found to be 56·1 % ( n 454). The details on the study protocol are reported elsewhere ( 19 ) .…”

Section: Methodsmentioning

confidence: 99%

Effect of dietary habits on the risk of metabolic syndrome: Yazd Healthy Heart Project

Sarebanhassanabadi

Mirhosseini

Mirzaei

et al. 2017

Public Health Nutr.

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“…These values were larger than the value in our study on males and smaller than that among females. [ 18 ] In a study conducted in Korea by Hwang et al ., the incidence rates of MetS during a 5-year follow-up were 3% among males and 4.6% among females, respectively. Accordingly, the incidence of MetS in the present study was higher, compared to the study in Korea.…”

Section: Discussionmentioning

confidence: 99%

Incidence of metabolic syndrome and determinants of its progression in Southern Iran: A 5-year longitudinal follow-up study

et al. 2020

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Background: Metabolic syndrome (MetS) is a cluster of conditions increasing the risk of serious diseases. This study aimed to define the predictors of MetS incident in a community-based cohort in Southern Iran, during a mean follow-up period of 5.1 years. Materials and Methods: During the mean follow-up period of 5.1 years, a cohort study was conducted on 819 Iranian adults aged ≥18 years at baseline and followed to determine the incidence and predictors of MetS progression in Shiraz, a main urban region in the southern part of Iran. The International Diabetes Federation Guideline was used to detect the MetS. Multiple Cox's proportional hazards models were also used to estimate the predictors of new-onset MetS. Results: The prevalence of MetS was 25.9% at baseline, and the overall incidence of subsequent MetS was 5.45% (95% confidence interval [CI]: 4.47–6.59). The incidence of MetS was significantly higher in women (7.12% [95% CI: 5.52–9.05]) than in men (3.92% [95% CI: 2.80–5.34]). Moreover, it increased by 5.02 (95% CI, 3.75–6.58) among individuals who had one metabolic component and by 12.65 (95% CI, 9.72–16.18) for those who had three or more components ( P < 0001). The incidence of MetS was also analyzed using the multiple Cox's proportional hazards model for potential risk factors, and it was revealed that female gender (hazard ratio [HR] 2.45; 95% CI: 1.33, 4.50; P = 0.004), higher body mass index (HR 3.13; 95% CI: 1.43.6.84; P = 0.012), increased abdominal obesity (HR 1.45; 95% CI 0.85, 2.46; P = 0.045), smoking (HR 4.79; 95% CI 2.09, 10.97; P < 0.001), and lower high-density lipoprotein (HR 0.53; 95% CI: 0.29, 1.00; P = 0.044) significantly predicted the onset of MetS at baseline; however, age, systolic and diastolic blood pressure, serum uric acid, fasting blood glucose, cholesterol, triglyceride and creatinine, estimated glomerular filtration rate, marital status, level of education, and level of physical activity did not independently predict the onset of MetS when other covariates were considered. Conclusion: This study showed the high-incidence rates of MetS in males and females residing in Southern Iran. Therefore, the prevention through community-based lifestyle modification should be implemented to reduce the burden of MetS and its complications.

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The Incidence of Metabolic Syndrome and the Most Powerful Components as Predictors of Metabolic Syndrome in Central Iran: A 10-Year Follow-Up in a Cohort Study

Abstract: Background: Metabolic Syndrome (MetS) is rapidly growing in today's world as an important predictor for type 2 diabetes and cardiovascular disease.

Cited by 11 publications

References 28 publications

Incidence and prediction nomogram for metabolic syndrome in a middle-aged Vietnamese population: a 5-year follow-up study

Incidence and prediction nomogram for metabolic syndrome in a middle-aged Vietnamese population: a 5-year follow-up study

Effect of dietary habits on the risk of metabolic syndrome: Yazd Healthy Heart Project

Incidence of metabolic syndrome and determinants of its progression in Southern Iran: A 5-year longitudinal follow-up study

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