The incidence of leukemias in children and their clustering in space and time in South Moravian Province, Czechoslovakia

Zahálková, M; Bílek, Ondřej; Kubíková, A.; Běluša, M.

doi:10.1007/bf01675275

Cited by 3 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For childhood leukaemia at time of diagnosis, a pooled analysis of 16 individual samples from 15 original studies [ 21 , 24 , 25 , 27 , 38 , 42 , 44 , 46 , 47 , 49 , 50 , 53 , 54 , 56 , 84 ] showed marginally significant space–time clustering ( p = 0.054) with an overall excess of close pairs of S = 1.1% (Table 2 , Fig. 2 ).…”

Section: Resultsmentioning

confidence: 99%

Space–time clustering of childhood cancers: a systematic review and pooled analysis

et al. 2018

View full text Add to dashboard Cite

The aetiology of childhood cancers remains largely unknown. Space–time clustering of cases might imply an aetiological role of infections. We aimed to review the evidence of space–time clustering of specific childhood cancers. We searched Medline and Embase for population-based studies that covered a pre-defined study area, included cases under 20 years of age and were published before July 2016. We extracted all space–time clustering tests and calculated the proportion of positive tests per diagnostic group. In a pooled analysis, we performed a Knox test of the number of pairs of cases close to each other in time and space pooled across studies. 70 studies met our eligibility criteria, 32 of which reported Knox tests. For leukaemia, the proportion of positive tests was higher than expected by chance at both time of diagnosis (26%) and birth (11%). The pooled analysis showed strong evidence of clustering at diagnosis for children aged 0–5 years for a spatial and temporal lag of 5 km and 6 months, respectively (p < 0.001). The evidence was mixed for lymphoma and tumours of the central nervous system. The current study suggests that leukaemia cases cluster in space–time due to an aetiological factor affecting children under 5 years of age. The observed pattern of clustering of young children close to time of diagnosis is compatible with Greaves’ delayed-infections-hypothesis.Electronic supplementary materialThe online version of this article (10.1007/s10654-018-0456-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Resultsmentioning

confidence: 99%

Space–time clustering of childhood cancers: a systematic review and pooled analysis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A number of previous studies from parts of Europe, Australia and the USA have demonstrated statistically significant space‐time clustering amongst cases of childhood leukaemia and especially among cases of acute lymphoblastic leukaemia (ALL) in the childhood peak 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32…”

mentioning

confidence: 99%

Space‐time clustering of childhood cancer in great Britain: A national study, 1969–1993

McNally

Alexander

Bithell

2006

Intl Journal of Cancer

View full text Add to dashboard Cite

Previous studies have provided evidence that infections may play a part in the aetiology of certain childhood cancers. The finding of space-time clustering indicates the presence of an environmental component to aetiology and is especially supportive of a role for infections. Space-time clustering occurs when excess numbers of cases of a disease are observed within small geographical locations at limited periods of time and this cannot be explained in terms of general excesses in those locations or at those times. To investigate whether infections may be involved in the aetiology of childhood cancer, we have analysed for space-time clustering using a large set of national population-based data from Great Britain for the period 1969-1993. Data were examined by a second-order procedure based on K-functions, with fixed thresholds of closeness in space (0.5-7.5 km) and closeness in time (0.1-1.5 years). Locations were addresses at diagnosis. Tests were repeated, replacing geographical distances with distances to the 19th-33rd nearest neighbours and this provided the primary result for each analysis. There were a total of 32,295 cases of childhood cancer. The analyses showed statistically significant evidence of space-time clustering for acute lymphoblastic leukaemia over the whole age range (p 5 0.04), but especially for ages 1-4 years (p 5 0.03). There was less statistically significant evidence for total leukaemia (p 5 0.048). Significant space-time clustering was also evident for soft tissue sarcomas (p 5 0.03) and osteosarcomas (p 5 0.02). Results support other evidence suggesting a role for infections in the aetiology of these particular diagnostic groups. ' 2005 Wiley-Liss, Inc.

show abstract

Clustering Studies for Identifying the Role of Environmental Factors in Aetiology of Human Cancers

McNally

2010

Environmental Factors, Genes, and the Development of Human Cancers

View full text Add to dashboard Cite

The incidence of leukemias in children and their clustering in space and time in South Moravian Province, Czechoslovakia

Cited by 3 publications

References 12 publications

Space–time clustering of childhood cancers: a systematic review and pooled analysis

Space–time clustering of childhood cancers: a systematic review and pooled analysis

Space‐time clustering of childhood cancer in great Britain: A national study, 1969–1993

Clustering Studies for Identifying the Role of Environmental Factors in Aetiology of Human Cancers

Contact Info

Product

Resources

About