The incidence of hyperthyroidism in patients with thyroid cancer in an area of iodine deficiency

Gülçelik, Mehmet Ali; Gülçelik, Neşe Ersöz; Dinç, Soykan; Kuru, Bekir; Camlibel, Mithat; Ağuş, Haluk

doi:10.1002/jso.20508

Cited by 24 publications

(12 citation statements)

References 15 publications

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“…These controversies may be due to the populations studied, treatment modalities, or patient factors. In the present study, we evaluated the importance of several factors to the prognosis of DTC in 382 patients living in an iodine-deficient area [10,11]. In our study, the mean age at diagnosis was 47 years and the female to male ratio was 2.7/1.…”

Section: Discussionmentioning

confidence: 97%

Prognostic factors determining survival in differentiated thyroid cancer

Gülçelik¹,

Gülçelik²,

Kuru³

et al. 2007

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 97%

Prognostic factors determining survival in differentiated thyroid cancer

Gülçelik¹,

Gülçelik²,

Kuru³

et al. 2007

Journal of Surgical Oncology

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“…However, under several pathological conditions like Graves' disease, tumors of thyroid and pituitary gland stimulate thyroid cells to produce more hormones, which results in a hyperthyroid state [2]. Alterations in the level of these hormones lead not only to altered basal metabolic rate but also to many health problems.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Protective Effects ofBupleurum falcatumon the L-Thyroxine-Induced Hyperthyroidism in Rats

Kim

Chung

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Bupleuri Radix (BR), the dried roots ofBupleurum falcatumL., has been used in folk medicine as an antiinflammatory and antioxidative agent. The aqueous extract of BR was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in l-thyroxine- (LT4-) induced rat model. After oral administration of 300, 150, and 75 mg/kg of BR extracts, once a day for 15 days from 12th LT4 treatments, changes on the body, thyroid gland, liver, and epididymal fat pad weights, serum triiodothyronine, thyroxine, thyroid-stimulating hormone, asparte aminotransferase and alanine aminotransferase concentrations, hepatic lipid peroxidation, glutathione contents, superoxide dismutase, and catalase activities were investigated with thyroid gland, liver, and epididymal fat histopathological changes. The effects of BR extracts were compared with that of propylthiouracil, a standard antithyroid drug 10 mg/kg (intraperitoneally). In this experiment, BR extracts dose dependently reversed LT4-induced hyperthyroidisms, and these effects indicating their potential in the regulation of hyperthyroidism. Further, the BR extract normalized LT4-induced liver oxidative stresses, and also reduced liver and epididymal fat pad changes. BR extracts 150 mg/kg showed comparable effects on the LT4-induced rat hyperthyroidism as compared with PTU 10 mg/kg. These effects of BR may help the improvement of hyperthyroidisms and accompanied various organ damages.

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“…One study showed a 2.8% incidence of hyperthyroidism among patients with thyroid malignancy in an iodine-deficient area. [ 4 ] The reported sites of autonomous hyperfunctioning thyroid cancer are either at the primary site at the thyroid bed, which is seen as a hot nodule on thyroid scintigraphy,[ 1 5 6 7 8 9 ] or at a metastatic site. [ 10 11 12 13 14 15 ] Some reported the mechanism of activated receptors on the cancer cells with high level of TSH-binding inhibitory immunoglobulin and thyroid stimulating antibody in the absence of thyroid tissue, occurred in metastatic site after the completion of radioiodine treatment for many years.…”

Section: Discussionmentioning

confidence: 99%

A case report of hyperfunctioning metastatic thyroid cancer and rare I-131 avid liver metastasis

2016

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Thyroid cancer is usually, relatively hypofunctional; most patients with thyroid cancer are clinically euthyroid. The combination of thyroid cancer and thyrotoxicosis is not common. We herein, report a case of follicular thyroid cancer with hyperfunctioning metastasis in a 43-year-old woman who presented with thyrotoxicosis, a cold right thyroid nodule, and low I-131 uptake at the thyroid bed. An additional total body scan with I-131 revealed a large radioiodine avid osteolytic bone metastasis with soft tissue masses and liver metastasis. The patient received treatment with total thyroidectomy, methimazole, and I-131 at a cumulative dose of 600 mCi along with recombinant human thyroid-stimulating hormone before the first I-131 treatment and palliative radiation. The patient had normal liver function test and experienced a mild degree of bone marrow suppression after I-131. At the 2-year follow-up, the patient was still alive with the progression of bone metastases but was doing well with less severe thyrotoxicosis, good ambulation, and an Eastern Cooperative Oncology Group performance status of 2. Clinicians should be aware of the unusual concurrent presentation of thyrotoxicosis and thyroid cancer, a differential diagnosis in patients with thyrotoxicosis and low or normal radioiodine uptake over the neck and also potential pitfalls during radionuclide treatment.

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The incidence of hyperthyroidism in patients with thyroid cancer in an area of iodine deficiency

Abstract: The existence of hyperthyroidism among patients with differentiated TC is a clinical entity. Patients with hyperthyroidism and nodules require a careful approach in order to establish or exclude the possibility of TC especially in formerly iodine deficient areas.

Cited by 24 publications

References 15 publications

Prognostic factors determining survival in differentiated thyroid cancer

Prognostic factors determining survival in differentiated thyroid cancer

Antioxidant and Protective Effects ofBupleurum falcatumon the L-Thyroxine-Induced Hyperthyroidism in Rats

A case report of hyperfunctioning metastatic thyroid cancer and rare I-131 avid liver metastasis

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