1989
DOI: 10.1001/archsurg.1989.01410120032007
|View full text |Cite
|
Sign up to set email alerts
|

The Incidence of Decreased Red Blood Cell Deformability in Sepsis and the Association With Oxygen Free Radical Damage and Multiple-System Organ Failure

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

5
57
1
2

Year Published

1995
1995
2021
2021

Publication Types

Select...
7
2
1

Relationship

1
9

Authors

Journals

citations
Cited by 108 publications
(65 citation statements)
references
References 14 publications
5
57
1
2
Order By: Relevance
“…Although this study could not determine the source(s) of catalytic iron, we found a significant association between plasma catalytic iron and free hemoglobin levels, suggesting that free hemoglobin from ex vivo hemolysis (e.g., pRBC transfusions) and/or in vivo hemolysis (e.g., sepsis) (31,32) are potentially relevant sources. Supporting this notion, we found a significant dose-response relation between pRBC transfusions before ICU arrival and plasma catalytic iron levels on ICU day 1.…”
Section: Discussionmentioning
confidence: 60%
“…Although this study could not determine the source(s) of catalytic iron, we found a significant association between plasma catalytic iron and free hemoglobin levels, suggesting that free hemoglobin from ex vivo hemolysis (e.g., pRBC transfusions) and/or in vivo hemolysis (e.g., sepsis) (31,32) are potentially relevant sources. Supporting this notion, we found a significant dose-response relation between pRBC transfusions before ICU arrival and plasma catalytic iron levels on ICU day 1.…”
Section: Discussionmentioning
confidence: 60%
“…The more compact the diameter on the OSCPs (50 nm) is, the more often the influence of it's to cells and the molecular effects of it's about the intracellular systems increases. Earlier scientific studies, demonstrated that reactive oxygen species (ROS) caused by nanoparticles are able to bring about damage of red blood cells [14,15] and also the information exhibited various consequences based on switches within the diameter of nanoparticles, the distribution of theirs in the route and body tissues of consumption as well as time period of exposure. Actually ROS through the of OSCPs have assaulted hepatocytes and also available ALT kept in them putting in into the blood serum; whereas; the immune effect of mice to an outside element continues to be the expansion on the variety of white blood cells for phagocytosis of Nanosilver particles [16].…”
Section: Discussionmentioning
confidence: 99%
“…The first mechanism is thought to be mediated by free radical-induced deformities of the RBCs. 18 The cellular defect in the ability to utilize O 2 is possibly aggravated by the increased PCOOH, which may render hepatocytes less able to accept and utilize O 2 , causing a significant fall in ATP and EC. α-Tocopherol was found to be significantly low in model 3 after 24 h (P Ͻ 0.001).…”
Section: Discussionmentioning
confidence: 99%