The incidence of congenital anomalies associated with cleft palate/cleft lip and palate in neonates in the Konya region, Turkey

Altunhan, Hüseyin; Annagür, Alı; Konak, Murat; Ertuğrul, Sabahattin; Örs, Rahmi; Koç, Hasan

doi:10.1016/j.bjoms.2011.08.001

Cited by 33 publications

(37 citation statements)

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“…Regional epidemiological studies have revealed the same trend in the Middle East (Rawashdeh and Jawdat Abu-Hawas, 2008;Beriaghi et al, 2009;Altunhan et al, 2011;Yazdee et al, 2011). For example, nearly 25% of 121 cleft palate (CP) and CLP patients in a Turkish study had a cardiovascular anomaly, representing the most common congenital defect in this population (Altunhan et al, 2011). The incidence of cardiovascular malformations in CL/P has been estimated to be 16-fold higher than that in the general pediatric population, prompting some to propose routine echocardiographic screening for congenital heart disease in CL/P patients (Milerad et al, 1997).…”

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confidence: 79%

“…A European study of 3860 patients with cleft lip (CL) or combined cleft lip and palate (CLP) identified malformations of the cardiovascular system in at least 7% of patients, not including those with recognized syndromes and chromosomal abnormalities (Calzolari et al, 2007). Regional epidemiological studies have revealed the same trend in the Middle East (Rawashdeh and Jawdat Abu-Hawas, 2008;Beriaghi et al, 2009;Altunhan et al, 2011;Yazdee et al, 2011). For example, nearly 25% of 121 cleft palate (CP) and CLP patients in a Turkish study had a cardiovascular anomaly, representing the most common congenital defect in this population (Altunhan et al, 2011).…”

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confidence: 92%

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The Impact of Congenital Cardiovascular Malformations on the Assessment and Surgical Management of Infants with Cleft Lip and/or Palate

Harry

Tebockhorst

Deleyiannis

2013

The Cleft Palate-Craniofacial Journal

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confidence: 79%

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confidence: 92%

The Impact of Congenital Cardiovascular Malformations on the Assessment and Surgical Management of Infants with Cleft Lip and/or Palate

Harry

Tebockhorst

Deleyiannis

2013

The Cleft Palate-Craniofacial Journal

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“…Altunhan H. reported the incidence of congenital anomalies associated with CL/P was 66% in the Konya region, Turkey [11]. Additionally, the incidence of malformations was 32.2% in USA [2], 33.3% in Victoria, Australia [1], and 56% in Taiwan, China [7].…”

Section: Discussionmentioning

confidence: 99%

A Survey of Congenital Heart Disease and Other Organic Malformations Associated with Different Types of Orofacial Clefts in Eastern China

et al. 2013

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BackgroundA high incidence of orofacial clefts is reported in China, but no data has shown the relation between cleft types and the incidence of other defects so far. The aim of this study is to assess the incidence of congenital heart diseases and other organic defects associated with different types of orofacial clefts.Methodology and Principal FindingsAll children with orofacial clefts, which were sought out from the Health Information System of Shanghai Ninth People's Hospital between 1st Jan 2009 and 30th Dec 2011, were enrolled in this study. All subjects underwent a thorough examination and grouped by the cleft phenotype. The numbers and types of other organic defects were recorded and analyzed statistically using SPSS 17.0. Of 2180 cases reported as having orofacial clefts, 657 (30.1%) had other congenital abnormalities, which were significantly more common in cleft palate (47.9% (329/687)) than that in cleft lip (10.6% (80/755)) or cleft lip and palate (33.6% (248/738)) (P<0.01). In subgroups, unilateral cleft lip and palate had a statistically higher incidence of associated abnormalities than bilateral cleft lip and palate (P<0.01). The most common malformation was congenital heart disease, which counted 45.1% (296/657) of all malformations. Disorders of the central nervous system (14.3%(94/657)) and Skeletal anomalies (13.1%(86/657)) were also frequently associated. Additionally, the most common defect in heart was atrial septal defect, which was 39.7% (118/296) of all congenital heart diseases.Conclusions and SignificanceAs the high incidence of heart defects and other organic abnormalities in the children with cleft palate in Eastern China, special attention should be paid to them and echocardiography should be a proposed examination in the evaluation of children with cleft palate before any surgical correction being executed.

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“…Therefore, access to surgical treatment for underprivileged populations, rural or urban, is limited-especially for elective procedures. [6][7][8][9] The reported percentage of associated anomalies varies among cleft patients based upon geographic location and inclusion/ exclusion criteria but is expected to approximate to 21%. Parents, especially from rural areas, may believe that the child's cleft is caused by an extraordinary event such as an eclipse or by God's will or that it is a punishment for a wrongdoing.…”

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confidence: 99%

Cleft Lip and/or Palate

Brydon¹,

Conway²,

Kling³

et al. 2014

Journal of Craniofacial Surgery

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The data collected are from the largest reported cohort of orofacial cleft patients in India. The cleft type, sex distribution, and overall male predominance resemble previously reported distributions; however, fewer CP patients and greater cleft lip and palate patients presented than would be expected. The frequency of associated anomalies was lower than in previous reports. Although there is significant selection bias to milder cases from lower socioeconomic groups in this study, the large sample size is unique, and the data collected can provide a valuable framework to further study the epidemiology of cleft lip and/or palate in India.

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The incidence of congenital anomalies associated with cleft palate/cleft lip and palate in neonates in the Konya region, Turkey

Cited by 33 publications

References 16 publications

The Impact of Congenital Cardiovascular Malformations on the Assessment and Surgical Management of Infants with Cleft Lip and/or Palate

The Impact of Congenital Cardiovascular Malformations on the Assessment and Surgical Management of Infants with Cleft Lip and/or Palate

A Survey of Congenital Heart Disease and Other Organic Malformations Associated with Different Types of Orofacial Clefts in Eastern China

Cleft Lip and/or Palate

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