The Incidence of Colorectal Cancer During Pregnancy in Japan: Report of Two Cases and Review of Japanese Cases

Kitoh, Toshiyuki; Nishimura, Shigeyuki; Fukuda, Shin; Hirabuki, Shinya; Kaganoi, Junichi; Tokunaga, Yukihiko; Ohsumi, Kiyoshi

doi:10.1055/s-2007-993919

Cited by 17 publications

(7 citation statements)

References 9 publications

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“…7 The choice of therapy generally depends on operability of tumour and period of gestation. If patient is diagnosed in early stage, colorectal surgery can be performed safely before 26 weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

Colorectal cancer in pregnancy mimicking tuberculosis

Wadhwa

Nain

Kataria

et al. 2013

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionmentioning

confidence: 99%

Colorectal cancer in pregnancy mimicking tuberculosis

Wadhwa

Nain

Kataria

et al. 2013

Int J Reprod Contracept Obstet Gynecol

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“…La edad de presentación promedio en el cáncer de recto en el embarazo es de 31 años con un rango entre los 16 y 41 años (1,2,6,7). En algunas revisiones los casos de cáncer de recto que ocurren en menores de 40 años representan el 1-8%, y solo el 2% de los casos ocurre en menores de 30 años de edad (2,3,(7)(8)(9)(10)(11)(12).…”

Section: Epidemiologíaunclassified

Manejo del cáncer de recto durante el embarazo

et al. 2011

Rev. chil. obstet. ginecol.

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RESUMENEl cáncer de recto tiene baja incidencia en la mujer embarazada, su diagnóstico durante el embarazo suele ser tardío, pues sus síntomas son similares a los propios de la gestación. El diagnóstico tardío le confiere un peor pronóstico, aunque el embarazo en si mismo no afecta la evolución natural de la enfermedad. El pronóstico perinatal no se ve afectado por la neoplasia misma, incluso en casos con metástasis múltiples, sino por el tratamiento indicado. El manejo dependerá fundamentalmente del estadío de la neoplasia y de la edad gestacional. Se revisa la literatura médica acerca del cáncer rectal asociado con el embarazo y se plantea un protocolo de manejo. PALABRAS CLAVE: Cáncer rectal, embarazo SUMMARYRectal cancer has low incidence in the pregnant women. Its diagnosis during pregnancy is usually delayed, since cancer symptoms are quite similar to normal symptoms of gestation. Delayed diagnosis confers worse prognosis, although pregnancy itself does not affect natural evolution of the disease. The perinatal outcome is not affected by the neoplasia, even in cases with multiple metastases, but may be affected by the treatment. The treatment of rectal cancer will depend of the stage of the neoplasia and gestational age. We review published data regarding rectal cancer associated with pregnancy and propose a management protocol. KEY WORDS: Rectal cancer, pregnancy INTRODUCCIÓNEl diagnóstico de cáncer durante el embarazo es un problema infrecuente, pero grave. Los cán-ceres de diagnóstico más común durante el embarazo son: linfoma, leucemia, melanoma, carcinoma de mama, cáncer de cuello uterino, ovario, tiroides y por último el cáncer colorectal. Este último tiene una incidencia reportada de 0,002-0,1% (1-5), aproximadamente en un 50% de los casos de cán-cer colorectal, el tumor se localiza en el recto.Los síntomas del cáncer rectal incluyen alteración del transito intestinal y rectorragia, cuando se asocia a obstrucción intestinal se presentan náu-seas, vómitos y dolor abdominal; todo lo anterior son síntomas frecuentes en el embarazo, que explica el habitual retraso del diagnóstico. Tal vez por este motivo, el cáncer de recto durante el embarazo es habitualmente diagnosticado en estadíos avanzados. El manejo en cada caso debe ser individua-REV CHIL OBSTET GINECOL 2011; 76(4): 269 -274

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“…She did not have any ocular problems in her medical history. Applanation tonometry showed an intraocular pressure (IOP) of 62 mmHg (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) in the right eye and 40 mmHg (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) in the left eye. On slit lamp examina-tion, conjunctival hyperemia, corneal edema and a very shallow anterior chamber were found.…”

Section: Case Reportmentioning

confidence: 99%

“…Several studies have demonstrated that p53 suppresses cancer cell growth in vitro and they have suggested that the protein acts a regulator of cell growth and a tumor suppressor gene (11,12). From a speculative point of view, it is possible that the development of CRC during pregnancy could be attributed to alterations or mutations of p53 or its products, on the one hand, and to the state of tolerance of the maternal immune system to tumor cells acquired during pregnancy, on the other (11,13).…”

Section: P53: a Tumor Suppressor Proteinmentioning

confidence: 99%

Angle closure glaucoma induced by ritodrine

Güven¹,

Çoşkun

Ayhan³

et al. 2005

Acta Obstet Gynecol Scand

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Angle closure glaucoma (ACG) is an ophthalmologic emergency that must be managed rapidly with a proper treatment modality. The potential complications of ACG are optic nerve injury, corneal edema and decreased visual acuity. The predisposing ocular anatomy is lens-iris apposition and a shallow anterior chamber. Emotional upset, dim illumination, female gender, childbirth, pituitary apoplexy and drugs (such as vasodilators, sympathomimetic, parasympatholytic and parasympathomimetic agents that are used systemically or topically) can cause ACG to occur in susceptible eyes (1,2). Case reportA 40-year-old primigravid woman at 26 weeks' gestation was admitted with the main complaint of back pain. Physical examination confirmed synchronized uterine contractions at 7-min intervals. Blood pressure and temperature measurements were within normal limits. The patient was hospitalized for the evaluation of preterm labor.In fetal biometry the estimated fetal weight was found to be 900 g at 26 weeks' gestation (50% percentile of Birthweight for gestational age), the biophysical profile was normal except for the amniotic fluid index, which was 5 cm. Umbilical and middle cerebral arterial Doppler studies were normal without findings of redistribution. Considering the diagnosis of preterm labor, which was accompanied by presumptive urinary infection, empiric ampicillin-sulbactam intravenous (i.v.) 1.5 g q.i.d. and ritodrine (i.v.) 3 mg/h were instituted. In addition, an initial intramuscular (i.m.) dose of betamethasone 10 mg was given. Eight hours after admission, the intensity and frequency of contractions decreased, together with relief of back pain. The patient subsequently complained of the acute onset of retro-orbital pain and blurred vision, and occipital headache. On ocular examination, her visual acuity was 20/400 in the right eye and 20/20 in the left eye. She did not have any ocular problems in her medical history. Applanation tonometry showed an intraocular pressure (IOP) of 62 mmHg (10-22) in the right eye and 40 mmHg (10-22) in the left eye. On slit lamp examina-tion, conjunctival hyperemia, corneal edema and a very shallow anterior chamber were found. The pupilla of the right eye was moderately dilated and nonreactive. The left anterior chamber was also shallow, but the pupilla was reactive. A closed angle in both eyes was detected on gonioscopy. There was no excavation of the optic nerve head on both sides, but the right one was more hyperemic. Considering that the diagnosis was acute ACG, intravenous magnesium sulfate was given instead of ritodrine. In order to lower the IOP, mannitol 20% i.v. 1 g/kg, oral acetazolamide 250 mg q.i.d., pilocarpine 2% topically q.i.d., and timolol topically 0.5% b.i.d. were instituted. After treatment, IOP were normalized and vision was improved. Iridotomies with an Nd : YAG laser was performed successfully on both eyes after resolution of corneal edema on the right eye. The antiglaucoma medications were ceased and she continued to use pilocarpine 2% topically once a day on both ey...

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The Incidence of Colorectal Cancer During Pregnancy in Japan: Report of Two Cases and Review of Japanese Cases

Cited by 17 publications

References 9 publications

Colorectal cancer in pregnancy mimicking tuberculosis

Colorectal cancer in pregnancy mimicking tuberculosis

Manejo del cáncer de recto durante el embarazo

Angle closure glaucoma induced by ritodrine

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