The incidence of cleft lip, cleft palate, hydrocephalus and &lt;i&gt;spina bifida&lt;/i&gt; at Queen Elizabeth Central Hospital, Blantyre, Malawi

Msamati, BC; Igbigbi, Patrick Sunday; Chisi, J

doi:10.4314/cajm.v46i11.8572

Cited by 40 publications

(47 citation statements)

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“…22Y24 However, few studies in Africa had reported girls to be dominant. 5,6 Comparing the results indicates that boys still dominate cleft lip and cleft palate cases in KATH, irrespective of ethnic background.…”

Section: Discussionmentioning

confidence: 87%

“…4 In Malawi, there is a reported low prevalence rate for CL +/j P, 0.7 per 1000 live births. 5 Suleiman et al 6 found that the prevalence rate of clefting among a group of Sudanese hospital newborns in the city of Khartoum is 0.9 per 1000 live births. In Ghana, the only community-based study on cleft was reported by Agbenorku et al, where they reported a cleft lip/cleft palate prevalence of 5.0 per 1000 people in the Wudoaba communities in the southeastern border of Ghana.…”

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confidence: 98%

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Komfo Anokye Teaching Hospital Multidisciplinary Cleft Clinic

Agbenorku

Ansah²,

Acheampong³

et al. 2011

Journal of Craniofacial Surgery

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Section: Discussionmentioning

confidence: 87%

mentioning

confidence: 98%

Komfo Anokye Teaching Hospital Multidisciplinary Cleft Clinic

Agbenorku

Ansah²,

Acheampong³

et al. 2011

Journal of Craniofacial Surgery

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“…Reports of birth prevalence of OFCs from different African populations vary widely, from as low as 0.3/1,000 reported in Nigeria [17] to 1.65/1,000 reported in Kenya [18]. In Malawi, there is a reported low prevalence rate for cleft lip and/or palate, 0.7 per 1,000 live births [19]. Suleiman et al (2005) found that the prevalence rate of clefting among a group of Sudanese hospital newborns in the city of Khartoum is 0.9 per 1,000 live births [20].…”

Section: Epidemiologymentioning

confidence: 99%

Orofacial Clefts: A Worldwide Review of the Problem

Agbenorku

2013

ISRN Plastic Surgery

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Orofacial cleft is one of the commonest congenital abnormalities which impacts negatively on the life of the individual and to a large extent affects the family. Caused by the interaction of environmental and genetic factors, this abnormality brings about decreased quality of life. Management of this abnormality entails a team involving a cleft surgeon, speech therapist, dentist, orthodontists, and so forth. This study involves the review of the various literatures on orofacial clefts, discussing the problems on the genetic basis, associated syndromes, and their management. Counseling of prospective mothers should be promoted to ensure that the abnormality is prevented at the early stages. Education on orofacial clefts should be promoted to create awareness on its preventive measures. Much attention must be geared towards cleft genetics studies to identify potential risk factors which might be predisposing individuals to the anomaly.

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“…14 Based on the current population and crude birth rate in Uganda, the fact that postinfectious hydrocephalus accounts for 60% of hydrocephalus in infants, 1 and conservative estimates of hydrocephalus birth incidence (approximately 0.5/1000 births), 9,10 more than 1700 Ugandan infants per year can be anticipated to develop hydrocephalus. This would extrapolate to more than 45,000 new cases of hydrocephalus annually in all of sub-Saharan Africa (population > 770 million).neighboring nations.…”

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confidence: 99%

Endoscopic third ventriculostomy in the treatment of childhood hydrocephalus in Uganda: report of a scoring system that predicts success

Warf

Mugamba

Kulkarni

2010

PED

128

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Object In Uganda, childhood hydrocephalus is common and difficult to treat. In some children, endoscopic third ventriculostomy (ETV) can be successful and avoid dependence on a shunt. This can be especially beneficial in Uganda, because of the high risk of infection and long-term failure associated with shunting. Therefore, the authors developed and validated a model to predict the chances of ETV success, taking into account the unique characteristics of a large sub-Saharan African population. Methods All children presenting with hydrocephalus at CURE Children's Hospital of Uganda (CCHU) between 2001 and 2007 were offered ETV as first-line treatment and were prospectively followed up. A multivariable logistic regression model was built using ETV success at 6 months as the outcome. The model was derived on 70% of the sample (training set) and validated on the remaining 30% (validation set). Results Endoscopic third ventriculostomy was attempted in 1406 patients. Of these, 427 were lost to follow-up prior to 6 months. In the remaining 979 patients, the ETV was aborted in 281 due to poor anatomy/visibility and in 310 the ETV failed during the first 6 months. Therefore, a total of 388 of 979 (39.6% and [55.6% of completed ETVs]) procedures were successful at 6 months. The mean age at ETV was 12.6 months, and 57.8% of cases were postinfectious in origin. The authors' logistic regression model contained the following significant variables: patient age at ETV, cause of hydrocephalus, and whether choroid plexus cauterization was performed. In the training set (676 patients) and validation set (303 patients), the model was able to accurately predict the probability of successful ETV (Hosmer-Lemeshow p value > 0.60 and C statistic > 0.70). The authors developed the simplified CCHU ETV Success Score that can be used in the field to predict the probability of ETV success. Conclusions The authors' model will allow clinicians to accurately identify children with a good chance of successful outcome with ETV, taking into account the unique characteristics and circumstances of the Ugandan population.

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The incidence of cleft lip, cleft palate, hydrocephalus and <i>spina bifida</i> at Queen Elizabeth Central Hospital, Blantyre, Malawi

Cited by 40 publications

References 0 publications

Komfo Anokye Teaching Hospital Multidisciplinary Cleft Clinic

Komfo Anokye Teaching Hospital Multidisciplinary Cleft Clinic

Orofacial Clefts: A Worldwide Review of the Problem

Endoscopic third ventriculostomy in the treatment of childhood hydrocephalus in Uganda: report of a scoring system that predicts success

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