The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study

It is assumed that the severity of the multiple organ dysfunctions syndrome (MODS) in children who have experienced critical conditions in the neonatal period may influence the prevalence of chronic diseases in the preschool age.The aim of the studywas to study the relationship between the severity of organ dysfunction in children who had undergone critical conditions in the neonatal period, and the prevalence of chronic diseases in preschool age.Methods.The study included children with MODS, the severity of which was assessed on the NEOMOD scale (moderate dysfunction ≤4 points, severe ≥5 points). Data on the prevalence of chronic diseases were obtained from the history of the child’s development (form № 112/y), a card for preventive medical examination of a minor (form № 030-PO/y-12), objective examination data, laboratory and instrumental survey methods, examination data by narrow specialists.Results.The study included 198 children, 100 of them with severe manifestations of SPON and 98 with moderate manifestations of SPON. The groups were comparable by sex, age, social factors (age and level of education of parents), place of residence (city/ village). Chronic diseases in preschool age occurred in 54% and 26% of cases, respectively, p<0.001. The most frequent were psychiatric and behavioral disorders: 40% and 16%, p<0.001, including coarse psychomotor development delay (PDD) of 18% and 1%, p <0.001; diseases of the nervous system: 30 and 14%, p=0.010, including cerebral palsy (CP) 25% and 8%, p=0.002; diseases of the eye: 28% and 24%, p=0.517, including amblyopia 8% and 3% of cases, p=0.113, respectively. Disability occurred in 19 (19%) cases in the main group, and in 5 (5%) cases in the comparison group (p=0.003).The conclusion.Severe manifestations of MODS in the neonatal period are associated with a higher frequency of coarse PDD and CP in preschool age than mild manifestations of MODS, severe manifestations of MODS are not associated with an increase in the frequency of pathology of the eye.

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The Prevalence of Chronic Diseases in Children who Have Undergone Critical Periods with A Different Severity of Organ Dysfunction in the Neonatal Period: A Retrospective Cohort Study

Серебрякова

Намазова-Баранова

Беляева

et al. 2018

Pediatr. farmakol.

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Topical therapy of acute viral rhinosinusitis in case of incomplete epithelialization of surgical wound during the long-term period of adenoid surgery

Kiselev,

Chaukina,

Krasnov

et al. 2024

Medicinskij sovet

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Acute respiratory infection (ARI) of the upper respiratory tract with incomplete epithelialization of the nasopharynx after surgery of the pharyngeal tonsil using cold sodium plasma is a little-studied problem.Aim. To evaluate the clinical efficacy and adequacy of topical therapy of acute viral rhinosinusitis with 2% silver proteinate (Sialor® preparation, tablets for preparation of a solution for topical use, 200 mg, in a bottle with a spray nozzle) instead of using systemic and local antibiotic therapy in the period of incomplete epithelialization of an operating wound after surgical treatment of chronic adenoiditis associated with hypertrophy of the pharyngeal tonsil, by physical factors of destruction of lymphadenoid tissue.Materials and methods. We observed 64 patients who underwent surgical intervention in the site of the pharyngeal tonsil using different techniques. The epithelization status of the surgical wound in the nasopharynx was visualized using 2.4 mm flexible rhino-laryngo fiberscope examination of the nasopharynx performed on postoperative days 10, 20 and 30. We assessed the frequency rates of ARI during the first month follow-up period and the features of the clinical course of ARI according to the patient’s diary. The treatment included on-demand topical therapy with decongestants and Sialor (2% silver proteinate). Results and discussion. The duration of ARI and the severity of nasal symptoms are comparable to the course of mild to moderate ARI in children with preserved pharyngeal tonsil.Conclusion. Sialor topical therapy is an adequate choice instead of local and systemic antibiotic therapy to suppress the pathogenic microflora activity in ARI, to provide a local anti-inflammatory effect during the long-term period of pharyngeal tonsil surgery with incomplete epithelization. The incomplete epithelization of the nasopharynx is not an indication to administer systemic antibiotics in the presence of signs of ARI of the upper respiratory tract after pharyngeal tonsil surgery.

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The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study

Cited by 2 publications

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The Prevalence of Chronic Diseases in Children who Have Undergone Critical Periods with A Different Severity of Organ Dysfunction in the Neonatal Period: A Retrospective Cohort Study

The Prevalence of Chronic Diseases in Children who Have Undergone Critical Periods with A Different Severity of Organ Dysfunction in the Neonatal Period: A Retrospective Cohort Study

Topical therapy of acute viral rhinosinusitis in case of incomplete epithelialization of surgical wound during the long-term period of adenoid surgery

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