The incidence and survival outcomes of patients with primary cardiac lymphoma: A SEER‐based analysis

Abstract

This study aimed to evaluate the incidence and prognosis of primary cardiac lymphoma (PCL) by using the Surveillance, Epidemiology, and End Results Program (SEER) database. Patients diagnosed with PCL and the disease incidence in the SEER database from 1975 to 2016 were included. Overall survival (OS) and cause-specific survival (CSS) curves were calculated using the Kaplan-Meier method and compared by the log-rank test. Univariate and multivariable Cox proportional hazard regression analyses were used to identify associations with outcome measures. The incidence of PCL was 0.011/100 000, and a predominance of elderly and male patients was observed. A total of 144 patients were enrolled. The median age of onset was 68 (9-96) years, including 80 (55.6%) males and 64 (44.4%) females. Multivariate analysis revealed that age and chemotherapy were independent prognostic factors for OS (both P < .05). Ann Arbor stage and chemotherapy were independent prognostic factors for CSS (both P < .05). In terms of treatment modality, chemotherapy combined with surgery was an independent protective factor for OS and CSS (both P < .05). For patients with primary cardiac diffuse large B-cell lymphoma (cardiac DLBCL), multivariate analysis also showed that age, Ann Arbor stage, and chemotherapy were all independent prognostic factors for OS and CSS (all P < .05). Chemotherapy combined with surgery was associated with a significant benefit in terms of OS and CSS (both P < .05). Our study confirmed that older age and advanced Ann Arbor stage were independent risk factors for PCL, and treatment with chemotherapy or cooperation with surgery resulted in better long-term survival.

Development and validation of a nomogram prediction model for early mortality in patients with primary malignant cardiac tumors

“…Based on the maximum χ 2 and minimum P value in the X-tile software (18), the optimal cut-off value for age in PMCTs patients was objectively identified as 44 and 76 in the current study, which is considered to be more credible and accurate. In previous studies on PMCTs patients, age at diagnosis showed a strong prognostic association with OS (4,19). In our study, older age was found to be associated with higher odds of early mortality, with patients over 76-year old having the highest odds of early mortality, followed by the 44-76 age group and 44, which was similar to the optical age cut-off value for OS for PMCT patients (4).…”

A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement

“…According to the Surveillance, Epidemiology and End Results Program database between 1973 and 2015 [11] , in a total of 144 patients with PCL, more than 70% received chemotherapy. The 5-year overall survival and cause-specific survival rates were 36.1% and 47.2%, respectively.…”

A visual model for prognostic estimation in patients with primary diffuse large B-cell lymphoma of small intestine and colon: analysis of 1,613 cases from the SEER database

“…Ann Arbor staging and Primary site were also significantly associated with DLBCL prognosis ( 22 ). As a long-term widely used clinical staging method for NHL, Ann Arbor staging was easily got and accessible, and its predictive efficacy was comparable to that of the Lugano staging in prognostic estimation ( 23 ), so it was reasonable to use Ann Arbor staging as a predictor in this study.…”