The incidence and survival of acute de novo leukemias in Estonia and in a well-defined region of western Sweden during 1997–2001: A survey of patients aged ≥65 years

Palk, Katrin; Luik, Ene; Varik, Mirja; Viigimaa, Iige; Vaht, Krista; Everaus, Hele; Wennström, Lovisa; Stockelberg, Dick; Safai‐Kutti, Soodabeh; Holmberg, Erik; Kutti, Jack

doi:10.1016/j.canep.2009.12.004

Cited by 3 publications

(5 citation statements)

References 12 publications

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“…over the 4 consecutive 5-year periods studied by us. Indeed, we recorded a similar increase in the incidence of de novo AML in the two cohorts of elderly patients (aged ≥65 years) [2,3]. Likewise, equivalent observations have been made by some other workers in their studies on AML epidemiology [15,16].…”

Section: Discussionsupporting

confidence: 65%

“…Even more conspicuous was the difference in crude as well as age-adjusted incidence rates between de novo AL patients in western Sweden and Estonia regarding elderly patients (aged ≥65 years at diagnosis) studied by us over the years 1982–1997 [2] and 1997–2001 [3]. In this respect it was also clearly demonstrated that in both the western Swedish and Estonian age cohorts the difference in incidence rates for the total group of de novo AL patients as well as for the subgroups of AML and ALL patients persisted over time.…”

Section: Discussionmentioning

confidence: 99%

“…Details regarding evaluation of the reliability of these data, including data validation of the Swedish Acute Leukemia Registry, have been reported elsewhere by us [3]. …”

Section: Methodsmentioning

confidence: 99%

“…However, since it is firmly established that both the incidence and outcome of treatment and therefore survival of AL is highly dependent upon the age of the patient, we decided to divide the study patients into two groups. The older patients were therefore reported on separately [2], as in the survey comprising the years 1997–2001 [3]. …”

Section: Introductionmentioning

confidence: 99%

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The Incidence and Survival of Acute de novo Leukemias in Estonia and in a Well-Defined Region of Western Sweden during 1997–2001: A Survey of Patients Aged 16–64 Years

Wennström

Safai‐Kutti²,

Stockelberg³

et al. 2011

Acta Haematol

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Background: In a recent retrospective study, we investigated the incidence and survival of de novo acute leukemia (AL) patients aged 16–64 years over three 5-year periods (1982–1996) in Estonia and in the Western Swedish Health Care Region. The incidence rates were similar in the two countries, but the survival data were highly different. Thus, relative survival at 5 years for de novo AL patients in Estonia was virtually negligible, whereas the corresponding figures for the Swedish patients increased from 20.3 to 38.9% during the study period. Aim: To prospectively compare the results for incidence and outcome of de novo AL between the two countries during 1997–2001. Results: Incidence rates for de novo AL were lower in Estonia than in western Sweden but not significantly so. However, the survival for de novo AL patients in Estonia had improved considerably, with the relative survival at 5 years being 16.4%; such improvement was particularly seen in acute myeloid leukemia patients. For the Swedish patients, no change in survival was recorded. Conclusion: In Estonia, a remarkable improvement in outcome for young de novo AL patients was seen after 1996. Nevertheless, relative survival for the Estonian patients had still not reached the levels found in the Swedish cohort.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

“…Details regarding evaluation of the reliability of these data, including data validation of the Swedish Acute Leukemia Registry, have been reported elsewhere by us [3]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Incidence and Survival of Acute de novo Leukemias in Estonia and in a Well-Defined Region of Western Sweden during 1997–2001: A Survey of Patients Aged 16–64 Years

Wennström

Safai‐Kutti²,

Stockelberg³

et al. 2011

Acta Haematol

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“…Nowadays, the majority of enterprises are privately owned. It sought integration with greater Europe, and in 2004 it joined the North Atlantic Treaty Organization (NATO) and the EU [5]. …”

Section: Methodsmentioning

confidence: 99%

Acute de novo Leukemia in Estonia and Western Sweden 1982-2006: Positive Trend in the Survival of Acute Leukemia over 25 Years

Hulegårdh

Punab²,

Holmberg³

et al. 2016

Acta Haematol

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This study focuses on the incidence, treatment, and survival of de novo acute leukemia in a 25-year perspective in western Sweden and Estonia. At the beginning of our study, Estonia was a part of the Eastern bloc with planned economy, but since 1991 it is a member of the European Union and transforming into a market economy. Survival rates have steadily increased in both countries. However, a gap between their survival curves remains. Based on our data, it is difficult to explain the big difference in the 5-year relative survival in favor of western Sweden (55 vs. 22%). In Germany, there was a big difference in overall cancer survival between East and West Germany after the fall of the iron curtain, but today no difference is seen. Differences in survival are probably due to a higher proportion of intense chemotherapy regimens and a higher rate of hematopoietic stem cell transplantations in Sweden. Other important factors might be better supportive care and diagnostics as well as better adjuvant therapy. Better staff training and conditions in wards are also factors that might play an essential role.

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Sequential population-based studies over 25 years on the incidence and survival of acute de novo leukemias in Estonia and in a well-defined region of western Sweden during 1982–2006: a survey of patients aged ≥65 years

et al. 2013

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Estonia regained independence in 1991 after five decades of occupation by the Soviet Union. The present population-based survey was carried out over five consecutive 5-year study periods (1982-2006) on the incidence and survival of de novo acute leukemia patients aged ≥65 years at diagnosis in Estonia and in a well-defined area in western Sweden. During the study period of retrospective work (1982-1996), the first 10 years were carried out while Estonia was still under the mentorship of the Soviet Union. Over these years, Estonian hematologists did not have access to therapeutic measures readily available to Swedish hematologists, and the results for survival for western Swedish patients with acute myeloid leukemia (AML) far exceeded those of their Estonian counterparts. However, the results for acute lymphoblastic leukemia were equally dismal in the two countries. Subsequent prospective population-based studies were carried out during the years 1997-2006. A gradual improvement as to long-term relative survival of the Estonian AML patients was observed. When studying 2002-2006, no difference as regards relative survival at 5 years was anymore present between the two countries. Over the first 20 years of our population-based studies, it was repeatedly observed that the age-standardized incidence rate particularly for de novo AML was considerably higher for the western Swedish as compared to the Estonian cohorts. During the last 5-year study period (2002-2006), no such difference between the two countries was present, indicating that some true changes in the reporting procedure in Estonia had occurred.

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The incidence and survival of acute de novo leukemias in Estonia and in a well-defined region of western Sweden during 1997–2001: A survey of patients aged ≥65 years

Cited by 3 publications

References 12 publications

The Incidence and Survival of Acute de novo Leukemias in Estonia and in a Well-Defined Region of Western Sweden during 1997–2001: A Survey of Patients Aged 16–64 Years

The Incidence and Survival of Acute de novo Leukemias in Estonia and in a Well-Defined Region of Western Sweden during 1997–2001: A Survey of Patients Aged 16–64 Years

Acute de novo Leukemia in Estonia and Western Sweden 1982-2006: Positive Trend in the Survival of Acute Leukemia over 25 Years

Sequential population-based studies over 25 years on the incidence and survival of acute de novo leukemias in Estonia and in a well-defined region of western Sweden during 1982–2006: a survey of patients aged ≥65 years

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