The incidence and significance of Phase 1 complement-fixing antibody in Q fever

Powell, O. W.; Stallman, N. D.

doi:10.1017/s0022172400020477

Cited by 17 publications

(7 citation statements)

References 12 publications

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“…In 1962, Powell and Stallman found that detection of IgG I was associated with protracted convalescence from Q fever in the elderly. However, the authors stated that the presence of phase I antibodies was an indication of "past persistent infection" but that it was not necessarily proof of present persistent infection in the absence of clinical signs (382). One year later, the WHO study group on rickettsial diseases established a serological cutoff for phase I antibody titers at 1:200 for the diagnosis of "chronic Q fever" (383).…”

Section: Clinical Aspects Chronic Q Fever: From Historical Backgroundmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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Section: Clinical Aspects Chronic Q Fever: From Historical Backgroundmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…The inability of the workers to recall symptoms which could be attributed to a previous attack of Q fever is possibly explained by subclinical infections or because Q fever may pass unrecognized and be regarded as an attack of influenza or bronchitis. The presence of complement-fixing antibody to phase 1 antigen in two employees may indicate past persistent infection (Powell and Stallman, 1962).…”

Section: The Incidence Of Antibodies In Blood Donors In Great Britainmentioning

confidence: 99%

Occupational infections in the Edinburgh abattoir.

Schonell¹,

Brotherston²,

Burnett³

et al. 1966

BMJ

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“…Of diagnostic importance is the production of antibodies against C. burnetii antigens in a temporal manner, with phase II antibodies appearing early and phase I antibodies appearing somewhat later in the course of infection (7,14,19,25,34). Presence of phase I antibodies correlates well in older age groups with the duration of convalescence after the acute illness (34).…”

mentioning

confidence: 99%

Serological evaluation of O fever in humans: enhanced phase I titers of immunoglobulins G and A are diagnostic for Q fever endocarditis

Peacock¹,

Philip²,

Williams³

et al. 1983

Infect Immun

223

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Serological parameters were compared in 15 cases of Coxiella burnetii infection comprising 5 cases each of primary Q fever, chronic granulomatous hepatitis, and endocarditis. The diagnosis was made on the basis of clinical history and serology and on the isolation of C. burnetii phase I from biopsy specimens of liver and bone marrow from two patients with granulomatous hepatitis and from the aortic valve vegetations of five patients with endocarditis. The temporal sequences of immunoglobulin levels, rheumatoid factor, and specific antibody responses to phase II and phase I antigens of C. burnetii were evaluated as predictive correlates of the three Q fever entities. Serum levels of immunoglobulin classes G, M, and A were variable in all the entities of Q fever. Increased mean levels (in milligrams per deciliter) of immunoglobulin G (IgG) and IgA were noted with chronic disease in the sera of some patients, whereas IgM levels were not significantly different from normal values. Rheumatoid factor was significantly elevated in chronic disease but not in primary Q fever. The temporal sequence of C. burnetii phase II and phase I antibodies were compared by microagglutination, complement fixation, and indirect microimmunofluorescence tests. All of these serological tests were useful in distinguishing primary from chronic disease. Thus, the ratio of anti-phase II to anti-phase I antibodies was greater than 1, greater than or equal to 1, and less than or equal to 1 for primary Q fever, granulomatous hepatitis, and Q fever endocarditis, respectively. Moreover, the high phase-specific IgA antibody titers in the indirect microimmunofluorescence test were diagnostic for endocarditis.

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The incidence and significance of Phase 1 complement-fixing antibody in Q fever

Cited by 17 publications

References 12 publications

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

Occupational infections in the Edinburgh abattoir.

Serological evaluation of O fever in humans: enhanced phase I titers of immunoglobulins G and A are diagnostic for Q fever endocarditis

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