The incidence and outcomes of acute kidney injury amongst patients admitted to a level I trauma unit

Skinner, DL; Hardcastle, Timothy Craig; Rodseth, Reitze; Muckart, D. J. J.

doi:10.1016/j.injury.2013.07.013

Cited by 85 publications

(105 citation statements)

References 33 publications

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“…In our previous study examining AKI in critically ill patients, [10] we noted a low mortality rate among critically ill patients with sjambok injuries (23%), albeit in a small cohort of 13 patients. These findings contrast with other forms of trauma-associated AKI, where authors have reported mortality rates ranging from 28% to 100%.…”

Section: Discussionmentioning

confidence: 68%

Validating the utilisation of venous bicarbonate as a predictor of acute kidney injury in crush syndrome from sjambok injuries

et al. 2017

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Background. Crush injury secondary to sjambok beatings is a well-described phenomenon in southern Africa. Owing to a number of factors, it can result in acute kidney injury (AKI). In 1992, Muckart et al. described a risk stratification system using venous bicarbonate (VB) that can be used in the management of these patients. Objective. To validate this score in the modern era of AKI risk stratification. Methods. A retrospective study was performed on a local trauma database from June 2010 to December 2012. All patients with crush injury from sjambok/blunt instrument beatings were included in the analysis. VB was compared with the Kidney Disease Improving Global Outcomes scoring system for AKI. Serum base excess (BE) and creatine kinase were also examined as biomarkers. The endpoints were the need for renal replacement therapy (RRT) and mortality. Results. Three hundred and ten patients were included. The overall mortality rate was 1.9%, 14.8% of patients had AKI, and 3.9% required RRT. Both VB and BE performed well in RRT prediction, with areas under the receiver operating characteristic curve of 0.847 (95% confidence interval (CI) 0.756 -0.938; p<0.001) and 0.871 (95% CI 0.795 -0.947; p<0.001), respectively. The sensitivity and specificity of BE were 83.3% and 80.2% at an optimal cut-point of -7.25 mmol/L, while those of VB were 83.3% and 79.5% at an optimal cut-point of 18.85 mmol/L. VB was significantly different across the AKI risk groups (p<0.001), in keeping with the original Muckart risk stratification system. Conclusion. The risk stratification score using VB is valid and should continue to be used as a tool in the management of patients with sjambok injuries. BE performs well in predicting the need for RRT, with a value of <-7.25 mmol/L indicating severe injury.

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Section: Discussionmentioning

confidence: 68%

Validating the utilisation of venous bicarbonate as a predictor of acute kidney injury in crush syndrome from sjambok injuries

et al. 2017

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“…Although the patterns and burden of AKI among select surgical subgroups have been reported [19][20][21][22][23]27], few investigations have studied it in a general surgical cohort [23,25]. Indeed, one potentially valuable resource to study perioperative AKI, the American College of Surgeons-National Surgical Quality Improvement Program database, has limited sensitivity for renal dysfunction because it only includes renal events with serum creatinine greater than or equal to 2 mg/dL or requiring dialysis [24,28].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and outcomes of acute kidney injury in critically ill surgical patients

Harris

McCrone

Koo

et al. 2015

Journal of Critical Care

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“…The incidence of AKI in trauma patients ranges between 15% and 36% [13,14]. Advancing age and blunt trauma are known risk factors for AKI in trauma occurrence [14,15].…”

mentioning

confidence: 99%

Association of high volumes of hydroxyethyl starch with acute kidney injury in elderly trauma patients

Leberle¹,

Ernstberger²,

Loibl³

et al. 2015

Injury

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The incidence and outcomes of acute kidney injury amongst patients admitted to a level I trauma unit

Cited by 85 publications

References 33 publications

Validating the utilisation of venous bicarbonate as a predictor of acute kidney injury in crush syndrome from sjambok injuries

Validating the utilisation of venous bicarbonate as a predictor of acute kidney injury in crush syndrome from sjambok injuries

Epidemiology and outcomes of acute kidney injury in critically ill surgical patients

Association of high volumes of hydroxyethyl starch with acute kidney injury in elderly trauma patients

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