The incidence and management of peripheral nerve injury in England (2005–2020)

Comprehensive Development of a Cellulose Acetate and Soy Protein-Based Scaffold for Nerve Regeneration

“…Many people are affected by peripheral nerve injuries; according to recent studies, the mean incidence of this type of injury in England is 11.2 events per 100,000 persons per year [ 1 ] and 7.8 events per 100,000 persons per year in South Korea [ 2 ]. In developed countries, 13 to 23 of 100,000 persons/year are affected by nerve injuries [ 3 ] and more than 100,000 patients undergo nerve repair surgeries in the United States and Europe every year [ 4 ].…”

“…Treatment methods for nerve injuries can be categorized into surgical and nonsurgical treatments, depending on the type of nerve injury [ 5 ]. Surgical techniques are most frequently used in the treatment of neurotmesis [ 1 ], and the “gold standard” in the treatment of neurotmesis is autologous grafts [ 1 , 2 , 3 , 8 , 12 , 13 , 14 , 15 ]; however, the success rate of this therapy does not always result in correct nerve regeneration [ 14 , 16 ] and is associated with loss of function [ 1 , 3 , 10 , 14 ] and potential neuroma formation at the donor site [ 14 , 15 ]. To overcome these disadvantages, the development of NGCs to unite defects in peripheral nerves has been an important field of research in recent years [ 2 , 3 , 14 , 15 , 17 ].…”

“…NGCs are tubular scaffolds through which the regeneration of the lost nervous tissue is stimulated and directed [ 9 ]. The requirements of an ideal NGC include an architecture of mechanical properties that provide structural support, permeability, conductivity, flexibility, and biodegradability [ 1 , 3 , 13 ]. The design of NGCs is varied, and the configuration of the fibers, presence of pores and grooves, and thickness of the walls are fundamental to achieve successful nerve regeneration [ 1 , 13 , 18 ].…”

Mapping the hotspots and future trends of electrical stimulation for peripheral nerve injury: A bibliometric analysis from 2002 to 2023

“…Peripheral nerve injury is a critical and problematic clinical issue. An epidemiological study conducted in the United Kingdom revealed that the incidence of peripheral nerve injury was 11.2 per 100 000 people, which is comparable to the incidence of gastric or ovarian cancer 1 . Peripheral nerve injuries usually result in varying degrees of disability and pain, drastically lowering the quality of life of patients 2–4 .…”

“…An epidemiological study conducted in the United Kingdom revealed that the incidence of peripheral nerve injury was 11.2 per 100 000 people, which is comparable to the incidence of gastric or ovarian cancer. 1 Peripheral nerve injuries usually result in varying degrees of disability and pain, drastically lowering the quality of life of patients. [2][3][4] In a study of patients with upper limb nerve injuries which followed for an extended period of time, it was shown that hospitalization, rehabilitation, and socio-economic burden exceeded 40 526 euros per person, and that 30% of those with severe injuries had an additional annual cost of living of 16 872 euros.…”