The incidence and influence of antisperm antibodies in infertile human couples on sperm-cervical mucus interactions and subsequent fertility

Menge, Alan C.; Medley, Nadine E.; Mangione, Carol M.; Dietrich, John W.

doi:10.1016/s0015-0282(16)46578-7

Cited by 129 publications

(48 citation statements)

References 16 publications

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“…The incidence of sperm antibodies in high titer is greater in the sera of men of infertile than of men of fertile couples [13,14,28], Re ports from animal experiments also suggest that sperm antibodies may play a definite role in lowering fertility [29]. On the other hand, substantial evidence indicates that cellular immunity to sperm can be in- duced experimentally [30], and develops in infertile women [15] or after vasectomy [31].…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that these factors pro tect sperm from immunological damage in the male, and prevent sensitization of the female to sperm anti gens after insemination. This implies that an impair ment of the immunosuppressive function of SP might lead to immunological consequences such as immune infertility, in which cellular and humoral immune re sponses to sperm and SP could be elicited [13][14][15][16]. In addition, there are clinical conditions such as infec tion, malignancy in the genitourinary tract and acquired immune deficiency syndrome in which im munosuppression by SP might be relevant [17], How ever, little is known about the possible influence of SP on immune responses in vivo [5],…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Human Seminal Plasma Suppresses Delayed-Type Hypersensitivity Responses to Intravaginally Deposited Sheep Red Blood Cells and Sperm: Separation of Immunosuppressive Factors

Lee

Ha²

1989

Int Arch Allergy Immunol

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Although significant progress has been made in identifying the immunosuppressive factors in seminal plasma (SP) and their possible action in vitro, the potential role of SP in naturally occurring normal immune responses in vivo is less certain. Human SP or its fractions, administered 5 or 10 times at 3-day intervals into the mouse vagina simultaneously with washed human sperm or sheep red blood cells, suppressed the delayed-type hypersensitivity reactions to footpad injection of the antigens. However, SP failed to suppress antibody formation to these antigens in the applied experimental conditions. In an in vitro study, SP suppressed the proliferation of human peripheral blood mononuclear cells to phytohemagglutinin. This suppression of in vitro proliferation by SP was mediated by materials of both low (LMW) and high molecular weight (HMW). Among the HMW materials, a factor with approximately 1,500 kilodaltons, partially purified by DEAE-cellulose chromatography and gel filtration, exhibited the most potent suppressor activity in vitro and in vivo. The suppressive activities of SP or its fractions were not abolished by treatment with both heat (95 °C for 10 min) and trypsin (1.0 mg/ml, 37 °C for 4 h). These findings indicate that SP could contribute to the development of suppressed cellular immunity to sperm; immunosuppressive actions of SP are mediated by at least two distinct factors in vivo as well as in vitro.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human Seminal Plasma Suppresses Delayed-Type Hypersensitivity Responses to Intravaginally Deposited Sheep Red Blood Cells and Sperm: Separation of Immunosuppressive Factors

Lee

Ha²

1989

Int Arch Allergy Immunol

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“…Analysis of serum (indirect) from 698 infertile couples revealed 31.1 % of couples (16.5 % of the men and 21.6 % of the women) possessed at least one positive result for ASA [24]. In another study, serum from 186 men and 194 women and cervical mucus of 155 women and semen of 202 men were evaluated with direct and indirect immunobead binding tests.…”

Section: Immune Disordersmentioning

confidence: 99%

Definitions and Epidemiology of Unexplained Male Infertility

Güdeloğlu

Brahmbhatt

Parekattıl

2015

Unexplained Infertility

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“…The presence of antibodies in infertile women was found to be more than in those who were fertile. 24,56,72 Migration of spermatozoa in cervical mucus is impeded by antisperm antibodies. The motile spermatozoa become stationary or have shaky motility and their forward progression is halted.…”

mentioning

confidence: 99%

Immunobiology of Spermatozoa: A Review

Singhal

2014

Reproductive Biology Insights

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However, in most cases, there are no adverse immunological reactions in the female reproductive tract to ejaculated spermatozoa. 7 The reason for this could be the immuno-protective effect of seminal plasma, 8,9 which gets mixed with spermatozoa during ejaculation. In addition, factors like immune insult from bacterial infections 10,11 and female sex hormones 12 have been shown to influence the viability of spermatozoa and immune response against them in females. It has been found that there is sequential developmental change in the immunogenicity of a spermatozoon as it moves from rete testis toward the caput epididymidis, corpus epididymidis, and finally the cauda epididymidis. Indeed, it has been shown that rete testis spermatozoa are most immunogenic and cauda epididymidis spermatozoa are the least. This suggests that the spermatozoon loses its immunogenicity as it moves from rete testis toward the cauda epididymidis, and the immunogenicity of ejaculated spermatozoa could be less than those from the cauda epididymidis. ABSTRACT: Immunobiological changes in spermatozoa within the male reproductive tract are vital for their viability, and hence for reproductive efficiency. The secretions of the seminal vesicles have immunosuppressive property that attenuates the antigenic effects of spermatozoa in the male reproductive tract. However, when spermatozoa find a way to outside of the rete testis or epididymis due to trauma or infection, they can cause significant inflammatory and immunological reactions in the surrounding tissues. This has also been observed in the female reproductive tract. However, such cases are rare and the reason for this is unknown. Antisperm antibodies are the main cause of infertility in humans. The purpose of this review is to analyze these immunobiological changes from the time of spermatozoa formation in rete testis to their role in fertilizing the oocytes in the female reproductive tract.

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The incidence and influence of antisperm antibodies in infertile human couples on sperm-cervical mucus interactions and subsequent fertility

Cited by 129 publications

References 16 publications

Human Seminal Plasma Suppresses Delayed-Type Hypersensitivity Responses to Intravaginally Deposited Sheep Red Blood Cells and Sperm: Separation of Immunosuppressive Factors

Human Seminal Plasma Suppresses Delayed-Type Hypersensitivity Responses to Intravaginally Deposited Sheep Red Blood Cells and Sperm: Separation of Immunosuppressive Factors

Definitions and Epidemiology of Unexplained Male Infertility

Immunobiology of Spermatozoa: A Review

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