The incidence and distribution of occult vaginal adenosis

Sandberg, Eugene C.

doi:10.1016/0002-9378(68)90058-6

Cited by 47 publications

(10 citation statements)

References 16 publications

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“…In a series of autopsies examined by Sandberg (6), occult vaginal adenosis was found in 41% of postpubertal patients and in 0% of prepubertal patients, suggesting that adenosis develops de novo after puberty rather than during vaginal embryogenesis. More recently, there have been reports of vaginal adenosis after different types of vaginal trauma such as the application of 5-FU (1–3), CO 2 laser vaporization (4), Stevens-Johnson syndrome (7) and contact irritation from a disinfectant used preoperatively (8).…”

Section: Discussionmentioning

confidence: 99%

Primary Vaginal Adenocarcinoma Arising in Vaginal Adenosis After CO2 Laser Vaporization and 5-Fluorouracil Therapy

Paczos

Ackers

Odunsi

et al. 2010

International Journal of Gynecological Pathology

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Summary We present a case of a 45-year-old woman with a long-standing history of persistent cervical dysplasia that resulted in a hysterectomy. Subsequent vaginal smears revealed high-grade vaginal intraepithelial neoplasia (VAIN III) on Pap smear with positive human papilloma virus (HPV) testing. Over the course of 2 years, the patient underwent 2 CO2 laser vaporization procedures of the upper vagina and intermittent 5-fluorouracil therapy. A biopsy performed at the time of the second laser procedure revealed endocervical-type well-differentiated adenocarcinoma, associated with VAIN III. HPV in situ hybridization for HPV types 16 and 18 was positive in both the glandular and squamous mucosa. The patient has no known history of intrauterine diethylstilbestrol exposure or mullerian developmental abnormalities. Subsequently, the patient underwent a radical upper vaginetcomy with bilateral pelvic lymph nodes dissection and bilateral salpingo-oophorectomy. The vaginectomy specimen showed residual adenocarcinoma associated with VAIN-III and extensive vaginal adenosis with free resection margins. This is the second reported case in the literature of adenocarcinoma arising in vaginal adenosis after 5-fluorouracil. Herein, we highlight these important findings and shed some light on the pathogenesis of vaginal adenosis and the subsequent development of vaginal adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Primary Vaginal Adenocarcinoma Arising in Vaginal Adenosis After CO2 Laser Vaporization and 5-Fluorouracil Therapy

Paczos

Ackers

Odunsi

et al. 2010

International Journal of Gynecological Pathology

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“…3 Histologic evaluation of step-sectioned vaginas from postpubertal autopsied patients who had no history of gynecologic abnormalities revealed a 41% incidence of vaginal adenosis, a 5% incidence of mesonephric duct remnant and a 9% incidence of endometrial implants. 9 In contrast to Sandberg's 9 findings, Frable et al discovered only one case of vaginal endometriosis in reviewing 2,206 posthysterectomy vaginal smears. 4 The patient described by Frable et al had a history of pelvic endometriosis and vaginal bleeding, and a gynecologic examination revealed a granular, mucosal lesion in the vaginal cuff.…”

Section: Discussionmentioning

confidence: 88%

Glandular Cells in Vaginal Smears from Posthysterectomy Patients

Ko²,

Rm³

1997

Acta Cytologica

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“…A spontaneous form of vaginal adenosis does exist, and it is reported to be surprisingly more frequent than expected. Sandberg 22 found occult vaginal adenosis in 9 (41%) of 22 vaginas from postpubertal girls at autopsy and none in 13 prepubertal patients. Similar findings were obtained by Kurman and Scully, 23 suggesting that vaginal adenosis can arise congenitally but that steroid hormones play a stimulatory role in their development.…”

Section: Discussionmentioning

confidence: 99%