The Incidence and Clinical Spectrum of Refractory Celiac Disease in a North American Referral Center

Abstract

Although RCD is a serious condition with significant morbidity; the observed mortality rates are low in our population. This study suggests that RCD may be less severe in North American vs. European populations.

Low incidence but poor prognosis of complicated coeliac disease: A retrospective multicentre study

“…Although it has been known for many years that the increased mortality in CD is due to its feared complications [23], the literature reports very few epidemiological data on these complications [8,[15][16][17][18][19]. This lack of data can undoubtedly be attributed both to the significant selection biases in these series of patients and to the difficulties caused by the lack of uniform diagnostic criteria for the various forms of CCD [15,16].…”

“…The funding source had no role.the prognosis [3][4][5][6][7]. In particular, the five-year survival rate is between 80% and 96% in patients with RCD1, between 40% and 58% in patients with RCD2 and drops to less than 20% in patients with CD complicated by EATL [8][9][10][11][12][13].…”

“…The first papers on the molecular diagnosis of complicated CD (CCD) were published more than 10 years ago [14], and since then several papers were published on this subject [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Despite these achievements, the literature still provides only minor and insufficient indications on the incidence of these conditions in patients with CD [8,[15][16][17][18][19].…”

“…Despite these achievements, the literature still provides only minor and insufficient indications on the incidence of these conditions in patients with CD [8,[15][16][17][18][19]. The reason for this lack of data can probably be attributed to the fact that most patients with CCD are sent to large referral centres.…”

Is Refractory Celiac Disease More Severe in Old Europe?

“…In the present issue, Roshan et al ( 14 ) ( Am J Gastroenterol 2011) report 34 RCD patients in a cohort of 844 celiac patients. Out these, only fi ve patients have RCDII and all others have RCDI.…”