The incentive amplifying effects of nicotine: Roles in alcohol seeking and consumption

King, Christopher P.; Meyer, Paul J.

doi:10.1016/bs.apha.2021.10.008

Cited by 4 publications

(2 citation statements)

References 261 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A motivation may be additive or interactive effects (as in the combination of alcohol and cocaine) or reduction or mitigation effects (as in the combination of cocaine and sedatives), which opened up a new field of study in polydrug use. Proof of this is the review by Bolieau-Falardeau et al [ 38 ], in which self-medication for a pre-existing condition is referred to as a possible third motivation, and the review by King & Meyer [ 39 ], studying the role of nicotine as a stimulant for the abuse of drugs such as alcohol.…”

Section: Resultsmentioning

confidence: 99%

Polydrug Definition and Assessment: The State of the Art

Font‐Mayolas

Calvo

2022

IJERPH

View full text Add to dashboard Cite

Polydrug use is a very common phenomenon and represents an important public health problem. The definition of the term has varied since its inception, and consequently so have forms of self-report evaluation. The aim of this review is to offer an overview of how the concept has evolved and its forms of evaluation through self-reporting. A search of the term polydrug was conducted on the PubMed portal up to August 2022, with a total of 2076 publications detected containing the word polydrug in their title, abstract or keywords. This includes publications that represent an advance in the definition and assessment of this construct through self-reports, which may be useful for researchers carrying out future studies in the field. The importance of distinguishing between concurrent and simultaneous polydrug use and the need to employ comparable measures in parameters for the frequency, magnitude and combination of psychoactive substances involved in polydrug use are two of the main recommendations emerging from this review.

show abstract

Section: Resultsmentioning

confidence: 99%

Polydrug Definition and Assessment: The State of the Art

Font‐Mayolas

Calvo

2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…In support of this idea, nicotine has been shown to increase the orienting response to a visual stimulus, which is often considered a measure of attentional processing (MacLeod et al, 2010 ; Meyer et al, 2015 , 2016 ). Alternatively, nicotine may enhance the incentive salience of the CS (King and Meyer, 2022 ), a proposition supported by findings from a range of behavioral paradigms across different research groups (Olausson et al, 2004 ; Palmatier et al, 2006 , 2007 ; Caggiula et al, 2009 ; Overby et al, 2018 ). This possibility is especially intriguing, as some groups have shown that the enhanced incentive salience of cues returns to control levels once nicotine treatment is stopped (Guy and Fletcher, 2014 ; Overby et al, 2018 ), suggesting a potent but short-lived effect of nicotine, which may have significance for eventual clinical applications.…”

Section: Discussionmentioning

confidence: 97%

β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue

Maddux

Gonzales²,

Kregar³

2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Nicotine enhances Pavlovian conditioned responses to reward-associated cues. We investigated through which nicotinic acetylcholine receptor (nAChR) subtypes nicotine acts to produce this behavioral effect to an alcohol-associated cue. Male Long-Evans rats with freely available food and water were first accustomed to drinking 15% ethanol in their home cages using an intermittent access, two-bottle choice procedure. Then the rats were given 15 Pavlovian conditioning sessions in which a 15-s audiovisual conditioned stimulus (CS) predicted the delivery of 0.2 ml of ethanol, the unconditioned stimulus (US). Each session contained 12 CS-US trials. A control group received explicitly unpaired presentations of the CS and US. We measured Pavlovian conditioned approach to the site of US delivery during presentations of the CS, accounting for pre-CS baseline activity. Before each conditioning session, rats were injected subcutaneously with nicotine (0.4 mg/kg) or saline (1 ml/kg). During nAChR antagonist test sessions, rats were first injected systemically with the β2*-selective nAChR antagonist dihydro-beta-erythroidine (DHβE; 3 mg/kg) or the α7-selective nAChR antagonist methyllycaconitine (MLA; 6 mg/kg), followed by their assigned nicotine or saline injection before assessing their conditioned response to the alcohol-associated cue. Consistent with previous reports, nicotine enhanced the Pavlovian conditioned response to the alcohol-paired cue. DHβE attenuated this enhancement, whereas MLA did not. These results suggest that nicotine acts via β2*, but not α7, nAChRs to amplify Pavlovian conditioned responding to an alcohol cue. These findings contribute to a growing literature that identifies nAChRs as potential targets for pharmacological treatment of co-morbid alcohol and tobacco use disorders.

show abstract