The inactivation of the non-enveloped enterovirus 71 (EV71) by a novel disinfectant gel formulation for topical use

Ma, Hai-Qiu; Wang, Ying; Mao, Yonghong; Wang, Shuyan; Zhang, Yu-Pu; Zuo, Chen-Qiang; Liang, Shao-Juan; Liu, Jun-Wei

doi:10.1080/03639045.2018.1562464

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…A new pyridyl imidazol idone compound (TJAB1099) can specifically inhibit the replication of EV-71 in vitro. However, TJAB1099 is insoluble in water, resulting in extremely low bioavailability, and is not suitable for oral absorption [18].…”

Section: Tjab1099mentioning

confidence: 99%

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Current status of drug treatment for hand foot mouth disease

Wu,

Yao,

You

2023

TNS

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Hand, foot, and mouth disease (HFMD) is an infectious disease caused by the intestinal RNA virus. Hand, foot, and mouth disease can occur every season, with no significant difference in specificity. However, the more frequent season of onset is spring and summer, with April to September as the main month of onset. Coastal areas are relatively popular areas of incidence. HFMD is mainly characterized by herpes with different sizes and clinical manifestations, such as in the hands, feet, and mouth. This article categorizes drugs into two categories: antiviral drugs and antiviral prevention. In describing antiviral drugs, they are classified them into traditional Chinese medicine and non-traditional Chinese medicine. At the same time, the two most effective and commonly used drugs or methods are summarized for preventing HFMD, namely the EV-71 virus vaccine for HFMD, and the washable hand sanitizer that prevents HFMD by blocking the transmission path of the virus. A comprehensive description and summary of the current treatment methods and drugs for combating and treating HFMD. This article provides a comprehensive description of different drugs by elaborating on their advantages and therapeutic principles, combined with their related pharmacological effects.

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Section: Tjab1099mentioning

confidence: 99%

“…A washing-free gel containing TJAB1099 was developed because Carbopol semi-solid gel is easy to dissolve with TJAB1099 in ethanol, and it will quickly liquefy after being heated by hand contact. This makes the development of TJAB1009 wash-free gel feasible [18].…”

Section: Tjab1099mentioning

confidence: 99%