The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids

Thorne, H. V.; Clarke, G. R.; Skuce, Robin

doi:10.1016/0166-3542(85)90003-8

Cited by 88 publications

(62 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1 -5] Found particularly in wild-type members of the genus Solanum, such as varieties of tomato, potato, and eggplant, [2] these compounds are regarded as toxic. [6 -8] However, researchers have also reported and referenced the use of certain glycoalkaloids for use in anti-cancer medications, [9 -14] for their medicinal or bioactive properties, [15,16] for their utility as precursors to the synthesis of useful pharmaceuticals, [5] and for their anti-fungal properties. [17] The interest in extracting these compounds and using them for medicinal purposes is shown, as well, in the form of several patents or patent applications.…”

Section: Introductionmentioning

confidence: 99%

Development of Practical HPLC Methods for the Separation and Determination of Eggplant Steroidal Glycoalkaloids and their Aglycones

Eanes

Tek

Kirsoy

et al. 2008

Journal of Liquid Chromatography & Related Technologies

View full text Add to dashboard Cite

A practical set of HPLC methods was developed for the separation and determination of the eggplant steroidal glycoalkaloids, solanine, chaconine, solasonine, solamargine, and their aglycones, solasodine and solanidine. A gradient method was initially developed, but proved to be neither robust nor practical. Three separate isocratic methods using acetonitrile and ammonium dihydrogen phosphate were developed and shown to be more repeatable, less subject to fluctuations in mobile phase composition, and less time consuming. The effect of adjusting buffer pH, column temperature, and buffer type (triethylammonium phosphate vs. ammonium dihydrogen phosphate) were evaluated. It was also discovered that, by addition of 10% methanol to the acetonitrile portion of the mobile phase, more control over the separations was possible. The use of methanol as a mobile phase entrainer greatly improved separations in some cases and its effectiveness was also dependent upon column temperature. Assessments of the method recovery, limit of detection, and limit of quantitation were made using extracts from S. melongena and S. linnaeanum.

show abstract

Section: Introductionmentioning

confidence: 99%

Development of Practical HPLC Methods for the Separation and Determination of Eggplant Steroidal Glycoalkaloids and their Aglycones

Eanes

Tek

Kirsoy

et al. 2008

Journal of Liquid Chromatography & Related Technologies

View full text Add to dashboard Cite

show abstract

“…Drug resistance is a major problem associated with the failure of treatment of human infections caused by this type of parasite and underscores the importance of the development of novel drugs (21)(22)(23). Plant products have long been used in traditional medicine to treat different types of illnesses (2,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) and are now considered a good alternative for drug discovery. There are promising compounds originally isolated from plants with leishmanicidal properties, which could be antileishmanial drugs with commercial potential.…”

Section: Discussionmentioning

confidence: 99%

“…(Solanaceae), also known as wolf fruit ("fruto-do-lobo"), have been used to treat a number of medical conditions. Preparations from this plant also display cytotoxic, antimicrobial, immunomodulatory, and antimutagenic activities (9)(10)(11)(12)(13)(14)(15)(16)(17)(18). We showed that alkaloids from this plant are lethal to Leishmania amazonensis promastigotes (9).…”

mentioning

confidence: 91%

A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways

Lezama-Dávila

McChesney

Bastos

et al. 2016

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Little has been done during the past 100 years to develop new antileishmanial drugs. Most infected individuals live in poor countries and have a low cash income to be attractive targets to pharmaceutical corporations. Two heterosidic steroids, solamargine and solasonine, initially identified as major components of the Brazilian plant Solanum lycocarpum, were tested for leishmanicidal activity. Both alkaloids killed intracellular and extracellular Leishmania mexicana parasites more efficiently than the reference drug sodium stibogluconate. A total of 10 M each individual alkaloid significantly reduced parasite counts in infected macrophages and dendritic cells. In vivo treatment of C57BL/6 mice with a standardized topical preparation containing solamargine (45.1%) and solasonine (44.4%) gave significant reductions in lesion sizes and parasite counts recovered from lesions. Alkaloids present different immunochemical pathways in macrophages and dendritic cells. We conclude that this topical preparation is effective and a potential new and inexpensive treatment for cutaneous leishmaniasis.

show abstract

“…Plants are thought to produce glycoalkaloids to protect themselves from attacks from microbes, insects and animals. Previous studies have shown that glycoalkaloids are biologically active as antifungals (Fewell & Roddick, 1993), antimicrobials (Wanyonyi et al, 2003), antivirals (Thorne et al, 1985), cancer chemotherapeutics (Kuo et al, 2000;Lee et al, 2004;Friedman et al, 2005), and embryotoxins (Friedman et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

In vivoantimalarial activities of glycoalkaloids isolated from Solanaceae plants

Chen¹,

Li²,

Sun³

et al. 2010

Pharmaceutical Biology

View full text Add to dashboard Cite

The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids

Cited by 88 publications

References 4 publications

Development of Practical HPLC Methods for the Separation and Determination of Eggplant Steroidal Glycoalkaloids and their Aglycones

Development of Practical HPLC Methods for the Separation and Determination of Eggplant Steroidal Glycoalkaloids and their Aglycones

A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways

In vivoantimalarial activities of glycoalkaloids isolated from Solanaceae plants

Contact Info

Product

Resources

About