volume 273, issue 49, P32554-32560 1998
DOI: 10.1074/jbc.273.49.32554
View full text
|
|
Share

Abstract: Low molecular weight phosphotyrosine-protein phosphatase (LMW-PTP) shares no general sequence homology with other PTPs, although it has an active site sequence motif CXXXXXR and a reaction mechanism identical to those of all PTPs. The main function of this enzyme is the down-regulation of platelet-derived growth factor and insulin receptors. Both human LMW-PTP isoenzymes are inactivated by H 2 O 2 . The enzymes are protected from inactivation by P i , a competitive inhibitor, suggesting that the H 2 O 2 react…

Expand abstract

Search citation statements

Order By: Relevance

Paper Sections

0
0
0
0
0

Citation Types

8
161
1
2

Publication Types

Select...

Relationship

0
0

Authors

Journals