Abstract:The transmembrane BAX inhibitor-1-containing motif 6 (TMBIM6) is an anti-apoptotic endoplasmic reticulum (ER) membrane protein. The suppression of apoptosis by TMBIM6 is linked to its role in regulating calcium homeostasis. However, the molecular mechanisms underlying the calcium regulation in the ER remain poorly understood. Using mutagenesis and fluorescence-based functional assays, this study investigates all the highly conserved negatively charged residues in the BsYetJ (a bacterial homolog of TMBIM6) and … Show more
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