The in vivo transfer of antigen-induced airway reactions by bronchial lumen cells.

Patterson, Roy; Suszko, Irena M.; Harris, Kathleen E.

doi:10.1172/jci109155

Cited by 50 publications

(10 citation statements)

References 10 publications

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“…The importance of inhalation as the route of choice is supported by recent re search in experimental asthma in animals [7,8). It has been shown that the antigenantibody interaction takes place in most cells within the airway lumen or in bron chial mucosal cells.…”

Section: Discussionmentioning

confidence: 99%

Bronchodilatory Effect of Inhaled versus Oral Salbutamol in Bronchial Asthma

Louridas¹,

Kakoura²,

Galanis³

et al. 1983

Respiration

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The bronchodilator effect of salbutamol inhalation was compared with the oral administration of the drug in 10 patients with bronchial asthma. The study consisted of treating each patient for 4 consecutive days with: (1) a combined regimen consisting of a 2-mg tablet of salbutamol and 10 puffs of salbutamol inhalation (100 μg in each puff) given in pairs of two puffs every 20 min (regimen 1); (2) salbutamol inhalation (regimen 2); (3) salbutamol tablet (regimen 3), and (4) placebo, tablet and inhalation (regimen 4). The bronchodilator effect was assessed measuring the forced expiratory volume in 1 s, the forced vital capacity and the peak expiratory flow rate. The bronchodilator response was significantly greater on the inhalation alone and the combined regimen than on the oral and placebo regimens. The combined regimen showed a better although not significant bronchodilatory response than the inhalation regimen. We conclude that the inhalation treatment with salbutamol is superior to the oral route of administration in treating bronchial asthma and that the oral treatment has an added effect.

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Section: Discussionmentioning

confidence: 99%

Bronchodilatory Effect of Inhaled versus Oral Salbutamol in Bronchial Asthma

Louridas¹,

Kakoura²,

Galanis³

et al. 1983

Respiration

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“…[15,16] have suggested that luminal HCC may be the ini tial site of reaction in IgE-mediated respira tory responses. If a similar situation exists in man, inhibition by drugs of mediator re lease from these cells may prevent allergeninduced bronchospasm by acting at an early stage in the development of an asthmatic at tack.…”

Section: Introductionmentioning

confidence: 99%

Histamine-Containing Cells from Bronchial Lavage of Macaque Monkeys. Time Course and Inhibition of Anaphylactic Histamine Release

Butchers¹,

Vardey²,

Skidmore³

et al. 1980

Int Arch Allergy Immunol

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Bronchial lavage of rhesus and cynomolgus monkeys provided leucocyte suspensions with viable histamine-containing cells (HCC) as 1–8% of the white cell population. These HCC released histamine on challenge with antiserum to human IgE. HCC from 2 monkeys with pulmonary and cutaneous hypersensitivity to Ascaris antigen (AA) released histamine on challenge with AA. The extent of histamine release was related to the concentration of antigen and antiserum, and histamine release was complete within 10 min of challenge. ( ± )Salbutamol and (––)isoprenaline were potent inhibitors of anaphylactic histamine release from HCC, but disodium cromoglycate and AH 9679 were relatively poor inhibitors. The HCC system combines the reproducibility of a cell suspension with a response to drugs similar to that of human lung fragments.

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“…Mast or basophil-like cells could be identified in the la vage of rhesus monkeys and could be stim ulated to release histamine in response to IgE-dependent challenge [Patterson et al, 1976b], Transfer of such bronchial lumen cells from an Ascaris-sensitive donor to a non-allergic recipient transferred an anti gen-specific bronchial reaction [Patterson et al, 1978]. Early experiments with bron chial lavage in human subjects recovered mast cells (0.3-0.7% of total cells) from the bronchial lumen, but functional studies were complicated by poor viability and high rates of spontaneous histamine re lease [Patterson et al, 1977].…”

Section: Human Bronchoalveolar Mast Cellsmentioning

confidence: 99%

The Function and Properties of Human Lung Mast Cells

Flint

Leung²,

Hudspith

et al. 1986

Respiration

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Mast cells may be recovered from human subjects by bronchoalveolar lavage. Such bronchoalveolar mast cells will release histamine in response to IgE-dependent challenge in a reaction that is dose-, time- and energy-dependent. They possess functional characteristics distinct from dispersed human lung mast cells. The percentage of mast cells within the bronchoalveolar cell population is critically dependent upon the underlying pathology. Greater numbers of mast cells may be recovered from the bronchoalveolar compartment of extrinsic asthmatics than from controls. In addition, bronchoalveolar mast cells from asthmatic subjects show an increased releasability of histamine in response to anti-IgE. Antigen challenge also leads to the release of histamine in vitro, demonstrating the potential for the antigen-specific initiation of bronchoconstriction in these subjects. Spontaneous release of histamine from bronchoalveolar mast cells of asthmatic subjects was also greater than in controls (up to 46%), a feature which may be related to non-immunological mechanisms of bronchoconstriction. Such non-immunological mechanisms have been further investigated utilising mannitol as a model of hyperosmolar histamine release. Mannitol induced a dose-dependent release of histamine from bronchoalveolar mast cells of normal subjects, and this release was significantly inhibited by sodium cromoglycate. The leukotrienes are putative major mediators of human asthma. After challenge with anti-IgE in vitro, dose-dependent release of leukotriene C4 and prostaglandin D2 occurs from the bronchoalveolar cells of normal subjects. The release of PGD2 shows significant correlation with histamine release. Lying superficially, bronchoalveolar mast cells would be readily accessible to inhaled antigen. Mediator release from such cells may be relevant to the pathogenesis of asthma.

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The in vivo transfer of antigen-induced airway reactions by bronchial lumen cells.

Cited by 50 publications

References 10 publications

Bronchodilatory Effect of Inhaled versus Oral Salbutamol in Bronchial Asthma

Bronchodilatory Effect of Inhaled versus Oral Salbutamol in Bronchial Asthma

Histamine-Containing Cells from Bronchial Lavage of Macaque Monkeys. Time Course and Inhibition of Anaphylactic Histamine Release

The Function and Properties of Human Lung Mast Cells

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