The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts

Wagner, Daniel S.; Delk, Nikkí A.; Lukianova‐Hleb, Ekaterina Y.; Hafner, Jason H.; Farach-Carson, Mary C.; Lapotko, Dmitri O.

doi:10.1016/j.biomaterials.2010.06.031

Cited by 99 publications

(146 citation statements)

References 54 publications

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“…Second, MCNPs serve as efficient photosensitizers with high absorption in the near-infrared region. [74][75][76][77] Therefore, they function as promising nanocarriers in photothermal and chemical combination therapy. Zhou et al 78 used these advantages to develop an effective dual-triggered (Hyal1/redox) chemophotothermal synergistic therapy nanomedicine, which presented efficient heat transformation for photothermal therapy.…”

mentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

413

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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mentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

413

268

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“…Here, we analyze several experimental techniques for the imaging and quantitative analysis of transient vapor nanobubbles as single events and we troubleshoot some related errors. Due to the multiple biomedical applications of NBs and related phenomena, [34][35][36][37][38] it should be noted that we consider the transient events, but not the materials (particles) that are often also called nanobubbles. 39, 40 We also do not consider the cavitation of preexisting bubbles that is well studied elsewhere.…”

mentioning

confidence: 99%

Experimental techniques for imaging and measuring transient vapor nanobubbles

Lukianova‐Hleb

Lapotko

2012

Applied Physics Letters

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Imaging and measuring transient vapor bubbles at nanoscale pose certain experimental challenges due to their reduced dimensions and lifetimes, especially in a single event experiment. Here, we analyze three techniques that employ optical scattering and acoustic detection in identifying and quantifying individual photothermally induced vapor nanobubbles (NBs) at a wide range of excitation energies. In optically transparent media, the best quantitative detection can be achieved by measuring the duration of the optical scattering time-response, while in an opaque media, the amplitude of the acoustic time-response well describes NBs in the absence of stress waves. Transient thermal evaporation and the generation of vapor bubbles are one of the basic processes accompanying non-stationary high-temperature heat-and mass-transfer in liquids. The science and the methods for the detection of inertial vapor bubbles of various origins were well developed for macro-and micro-sized bubbles and mainly employ their ability to emit pressure and to scatter the incident light. Recent developments in nanoscience reduced the spatial and temporal scale of vapor bubbles to nanometers and nanoseconds. [7][8][9][10]23,[27][28][29][30][31][32][33] Unlike their larger analogs, vapor nanobubbles (NBs) require much higher sensitivity and resolution of the detection methods for their imaging, quantification, and identification among other phenomena, such as transient heating and the generation of stress waves. Here, we analyze several experimental techniques for the imaging and quantitative analysis of transient vapor nanobubbles as single events and we troubleshoot some related errors. Due to the multiple biomedical applications of NBs and related phenomena, [34][35][36][37][38] it should be noted that we consider the transient events, but not the materials (particles) that are often also called nanobubbles.39, 40 We also do not consider the cavitation of preexisting bubbles that is well studied elsewhere. 41 While NBs may have various sources of energy (the heating of liquid above the boiling threshold, local rarefaction, and plasma discharge), we employed an experimental model of a single NB in water. Such a model provides maximal precision, control, and reproducibility in NB generation through the localized transient photothermal heating of liquid above the evaporation point. This was achieved through the optical excitation of individual 60 nm gold nanospheres in water with single short laser pulses (70 ps and 532 nm) at specific fluences above the NB generation threshold. We used the plasmonic conversion of optical energy into heat to control the maximal diameter and lifetime of the NBs through the fluence of a single laser pulse, as described in detail previously. [8][9][10]33 This experimental model includes an internal metal nanoparticle (NP) that acts as the source of the bubble energy during bubble generation and prevents the development of extreme temperatures and sonoluminescence at the collapse stage, 8,42 unlike "classical" bu...

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“…A noninvasive amplification of the optical scattering amplitude with the PNB (relative to that of AuNP), selective mechanical and speedy damage to specific cells with bigger PNB, and optical guidance of therapy via the damage-specific signals of the bubbles were presented. A study conducted by Wagner et al 10 once again confirmed that PNB was capable of serving as an in vivo tunable theranostic cellular agent in zebrafish hosting prostate cancer xenografts.…”

Section: Gold-based Nanomaterialsmentioning

confidence: 85%

Nanotheranostics – a review of recent publications

Wang¹,

Chuang²,

Ho³

2012

IJN

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Theranostics is referred to as a treatment strategy that combines therapeutics with diagnostics, aiming to monitor the response to treatment and increase drug efficacy and safety, which would be a key part of personalized medicine and require considerable advances in predictive medicine. Theranostics associates with both a diagnosis that tests patients for possible reactions to taking new medication and targeted drug delivery based on the test results. Emerging nanotechnology provides a great deal of opportunity to design and develop such combination agents, permitting the delivery of therapeutics and concurrently allowing the detection modality to be used not only before or after but also throughout the entire treatment regimen. The introduction of nanotheranostics into routine health care has still a long way to go, since evaluations on cytotoxicity, genotoxicity, and immunotoxicity of prospective nanotheranostics, demonstration of cost-effectiveness, and availability of appropriate accessible testing systems are still required. An extensive review, from a chemistry point of view, of the recent development of nanotheranostics and its in vitro and in vivo applications are herein presented.

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The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts

Cited by 99 publications

References 54 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Experimental techniques for imaging and measuring transient vapor nanobubbles

Nanotheranostics – a review of recent publications

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The in vivo performance of plasmonic nanobubbles as cell theranostic agents in zebrafish hosting prostate cancer xenografts

Cited by 99 publications

References 54 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Experimental techniques for imaging and measuring transient vapor nanobubbles

Nanotheranostics &ndash; a review of recent publications

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Product

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Nanotheranostics – a review of recent publications