The in vivo effects of Verbascum speciosum on wound healing

Kayır, Selçuk; Demirci, Yasemin; Demirci, Serpil; Ertürk, Engin; Ayaz, Ercan; Doğan, Ayşegül; Şahın, Fikrettin

doi:10.1016/j.sajb.2018.09.013

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…The topical application has accelerated the wound closure in terms of contraction and re-epithelialization of full-thickness, excisional wound in the rats during the healing process. As a mechanism of action, anti-inflammatory effect of Palmitoyl-GDPH has been suggested to be the main reason for the wound healing activity hence, it could enhance connective tissue formation [ 27 , 41 , 42 ]. Besides that, since the Palmitoyl-GDPH was acidic when it dissolved in water within the value of pH 3.6, it can further change the wound pH to be relatively more acidic.…”

Section: Resultsmentioning

confidence: 99%

The Therapeutic Effect and In Vivo Assessment of Palmitoyl- GDPH on the Wound Healing Process

et al. 2021

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The standard treatment of open wounds via the direct usage of therapeutic agents is not without limitations with respect to healing. Small peptides can create a favorable milieu for accelerating the healing of wounds. This study presents the potential of a novel fatty acid conjugated tetrapeptide (palmitic acid-glycine-aspartic acid-proline-histidine; Palmitoyl-GDPH) in alleviating wound healing. Tetracycline was employed as a standard control drug following its significance in wound healing including biologically active and antimicrobial effects. The peptide in liquid form was applied on to a 4 cm2 full thickness wound surgically induced at the dorsum of Sprague Dawley (SD) rats. The in vivo wound treatment with Palmitoyl-GDPH for eighteen days, histologically demonstrated an almost perfect healing exhibited by increased re-epithelialization, enhanced collagen deposition, and diminished scar formation compared to the controls. In addition, the well-developed epidermal-dermal junction and ultimate stimulation of hair follicle-growth in the Palmitoyl-GDPH treated group indicated the wound to have healed as functionally viable tissues. In general, the much lower hemogram values in the Palmitoyl-GDPH group indicated that the ongoing healing is en route to an earlier recovery. Additionally, the liver, kidney, and pancreas function biomarkers being within normal limits indicated the relatively non-toxic nature of Palmitoyl-GDPH at the used dosage. These results indisputably supported the great potential of this newly synthesized Palmitoyl-GDPH to be used as an effective therapeutic agent for wound healing (this actually means creating a new wound).

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Section: Resultsmentioning

confidence: 99%

The Therapeutic Effect and In Vivo Assessment of Palmitoyl- GDPH on the Wound Healing Process

et al. 2021

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“…This effect is probably similar to that of a previously studied plant in the same genus ( V. speciosum ) which showed fast wound contraction and resulted in shortening of the epithelialization period. 42 , 43 The observed wound-healing effects of the crude extract in mice might be due to its antibacterial and antioxidant activities.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Wound Healing Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root of Verbascum Sinaiticum Benth. (Scrophulariaceae) in Swiss Albino Mice

Essa,

Getahun,

Birhanu

2024

JEP

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Background The roots of Verbascum sinaiticum have been used traditionally for the management of wound in different regions of Ethiopia. Despite the presence of several claims and in vitro studies regarding its role in wound healing, no scientific studies have been conducted so far. Therefore, this study aims to scientifically evaluate the wound healing activities of the crude extract and solvent fractions of the roots of Verbascum sinaiticum in Swiss albino mice. Methods The dried root powder of Verbascum sinaiticum was extracted using 80% methanol by maceration technique. This was then fractionated with chloroform, ethyl acetate, and water. These extracts were formulated as ointment at 5% and 10% concentration by using simple base. Acute dermal toxicity was performed on mice. The wound healing potential was evaluated using excision, incision, and burn wound models. Results In excision wound, 10% and 5% of crude extract ointment provided a significant (P<0.001) percentage of contraction starting from day 4 and day 6 onwards respectively. Moreover, the rate of epithelialization was significantly (P<0.001) improved in 10% crude extract. In burn wound, 10% and 5% crude extract showed significant (P<0.001) wound contraction starting from day 4 and 8 onwards respectively. In both excision and burn wounds, a moderate concentration of fibroblast proliferation and collagen deposition was observed on the 10% crude extract. The 5% and 10% aqueous and ethyl acetate fractions produced a significant (P<0.001) percentage of wound contraction and shortening of epithelialization at different time points compared to simple ointment. Conclusion The results of this study demonstrated that the 80% methanolic crude extract, aqueous and ethyl acetate fractions of Verbascum sinaiticum root have wound healing potential which assimilates its traditional use.

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“…Ce qui améliorerait l'apport en nutriment et en oxygène nécessaires à l'angiogenèse, à la prolifération des fibroblastes et des kératinocytes au niveau de la plaie. Des études effectuées sur l'extrait de Verbascum speciosum (Scrophulariaceae) montrent que les flavonoïdes qu'il contient stimulent la prolifération des fibroblastes et la libération des facteurs de croissances (Kayir et al, 2018). Dans ce sens, EATs pourrait stimuler la prolifération des fibroblastes, ainsi que la néogenèse grâce aux flavonoïdes qu'il contient.…”

Section: Discussionunclassified

Evaluation de l’activité cicatrisante de l’extrait aqueux de l’écorce de tronc de Terminalia superba (Combretaceae)

Atto¹,

Zahui²,

Kpahie³

et al. 2023

Int. J. Bio. Chem. Sci

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Terminalia superba (Combretaceae) est une plante couramment utilisée en médecine traditionnelle africaine pour traiter plusieurs maladies entre autres les soins des plaies. Le but de notre étude était d’évaluer les propriétés cicatrisantes de l’écorce de tronc de Terminalia superba sur des plaies d’incision de second degré chez le rat Wistar. Cette étude s’est réalisée sur 30 rats repartis en 5 lots de 6 rats dont un lot témoin non traité et les 4 autres recevant des applications quotidiennes de substances tests. Les résultats ont montré que l’extrait aqueux d’écorce de tronc de Terminalia superba a entraîné une contraction importante des plaies qui atteint au quatorzième jour 96,29%, 92,22% et 90,73% pour les lots traités avec la plante respectivement aux concentrations 800 ; 400 et 200 mg/ml contre 53,32% et 37,91% pour les lots traités avec la Bétadine et le témoin. Cet effet est dû aux substances bioactives présentent au sein de la plante. Ces résultats suggèrent donc que cet extrait a une activité cicatrisante. In order to contribute to the enhancement of the use of plants used in traditional medicine for improving the health of populations including wound care, the aim of this study was to evaluate the healing properties of Terminalia superba bark of the runk on incision wounds in second degree in Wistar rats. This study was carried out on 30 rats divided into 5 batches of 6 rats, one of which was an untreated control and the other 4 received daily applications of test substances. The results showed a significant contraction reaches on the fourteenth day 96.29%, 92.22% and 90.73% for the batches treated with the plant respectively at concentrations 800, 400 and 200 mg/ml against 53.32% and 37.91% for the batches treated with Betadine and the control. This effect of the extract is due to the bioactive substances present in the plant. These results therefore suggest that this extract has a healing activity.

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The in vivo effects of Verbascum speciosum on wound healing

Cited by 11 publications

References 16 publications

The Therapeutic Effect and In Vivo Assessment of Palmitoyl- GDPH on the Wound Healing Process

The Therapeutic Effect and In Vivo Assessment of Palmitoyl- GDPH on the Wound Healing Process

Evaluation of Wound Healing Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root of Verbascum Sinaiticum Benth. (Scrophulariaceae) in Swiss Albino Mice

Evaluation de l’activité cicatrisante de l’extrait aqueux de l’écorce de tronc de Terminalia superba (Combretaceae)

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