The in-vivo assessment of Turkish propolis and its nano form on testicular damage induced by cisplatin

Seven, Pınar Tatlı; Seven, İsmail; Karakuş, Selcan; Mutlu, Seda İflazoğlu; Kaya, Şeyma Özer; Arkalı, Gözde; İlgar, Merve; Tan, Ezgi; Şahin, Yeşim Müge; Ismik, Deniz; Kilislioğlu, Ayben

doi:10.1016/j.joim.2021.08.002

Cited by 7 publications

(11 citation statements)

References 60 publications

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“…Propolis of different types is rich in polyphenolic compounds, chiefly flavonoids, cinnamic acids, and their esters [ 19 , 30 , 38 , 39 , 42 , 43 , 44 , 82 ]. In general, phenolic compounds, including flavonoids, are associated with the antimicrobial and anti-inflammatory activity of propolis extracts [ 4 , 14 , 38 , 44 , 66 ].…”

Section: Biologically Active Compounds Presented In Propolismentioning

confidence: 99%

“…Moreover, the rats that were administered cisplatin and propolis nanoform had better indexes of the malondialdehyde level and glutathione peroxidase and catalase activities of testicular tissues. Such a positive effect could be explained by better solubility of the nanoform than propolis [ 39 ]. The ethanolic extract of propolis (1 to 10) increases activities of mitochondrial respiratory complexes II and IV of the human spermatozoa in vitro without an influence on mitochondrial membrane potential.…”

Section: Main Biological Propertiesmentioning

confidence: 99%

“…Triterpenoids α-Amyrin Ethiopian propolis [64] Lupenone, α-amyrin and β-amyrin Cameroonian [76] Fatty acids Unsaturated fatty acids cis-11-Eicosenoic acid (C20:1, n-9), cis-11,14-eicosadienoic acid (C20:2, n-6), cis-5,8,11,14,17-eicosapentaenoic acid (C20:5), arachidonic acid (C20:4, n-6), linoleic acid (C18:2, c + t n-6), palmitoleic acid (C16:1), and γ-linolenic acid (C18: European brown poplar [42] Turkish (1.22 mg/g) [39] Croatian (0-6.39 mg/mL) [44] Irish, Czech, German [43] Romanian poplar [66] Polish [63] Naringenin Mexican [38] Pinostrobin Turkish (2.93 mg/g) [39] Plathymenin Nepalese [82] Flavanonols Pinobanksin 3-acetate Australian [15] Pinobanksin-3-O-propionate, pinobanksin-3-O-butyrate, pinobanksyn-3-O-pentenoate European brown poplar [42] Pinobanksin Turkish [39] Polish [63] Flavones Chrysin Polish [19,63] Mexican [38] European brown poplar [42] Turkish (2.94 mg/g) [39] Croatian (0-8.02 mg/mL) [44] Irish, Czech [43] Romanian poplar [66] Apigenin Brazilian red [14] European brown poplar [42] Croatian (0-1.23 mg/mL) [44] Polish [63] Table 1. Cont.…”

Section: Representatives Propolis Type Referencementioning

confidence: 99%

“…Scaptotrigona postica [61] Flavonols Quercetin Brazilian red [14] Mexican [38] European brown poplar [42] Romanian poplar [66] Polish [63] Kaempferol Mexican [38] European brown poplar [42] Croatian (0-0.672 mg/mL) [44] Polish [63] Galangin Polish [19,63] Turkish (0.09 mg/g) [39] Croatian (0-8.71 mg/mL) [44] Irish, Czech [43] Romanian poplar [66] Rutin Turkish [12] Brazilian red [14] Isoflavones Homopterocarpin, medicarpin, 4,7-dimethoxy-2-isoflavonol Brazilian red [34] Medicarpin Nepalese [82] Chalcons 2 ,3 ,4 -Trimethoxychalcone, 2 -hydroxy-3 ,4 -dimethoxychal-cone, 2 ,4 -dihydroxy-3 -methoxychalcone Australian [15] Phenolic acids Caffeic acid Turkish (0.17 mg/g) [12,39] Algerian [21] Polish [63] Ferulic acid Turkish (0.36 mg/g) [12,39] Croatian (0-1.370 mg/mL) [44] Romanian poplar [66] Polish [63] t-Cinnamic acid Turkish (0.05-0.14 mg/g or 3.95 mg/g) [12,39] p-Coumaric acid Croatian (0-1.031 mg/mL) [44] Romanian poplar [66] Polish [19,63] Table 1. Cont.…”

Section: Geopropolis Frommentioning

confidence: 99%

“…Among them are European propolis of the poplar type, Mediterranean propolis, Brazilian green propolis, Brazilian red propolis, Canadian propolis, Venezuelan propolis, Chinese propolis, Argentinian propolis, Turkish propolis, Algerian propolis, Egyptian propolis, Mexican propolis, Greek propolis, etc. [ 14 , 15 , 21 , 34 , 35 , 36 , 37 , 38 , 39 ]. The characteristics of each type of propolis depend on plant source, edaphoclimatic conditions, season, bee species, etc.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Variability and Pharmacological Potential of Propolis as a Source for the Development of New Pharmaceutical Products

et al. 2022

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This review aims to analyze propolis as a potential raw material for the development and manufacture of new health-promoting products. Many scientific publications were retrieved from the Scopus, PubMed, and Google Scholar databases via searching the word "propolis". The different extraction procedures, key biologically active compounds, biological properties, and therapeutic potential of propolis were analyzed. It was concluded that propolis possesses a variety of biological properties because of a very complex chemical composition that mainly depends on the plant species visited by bees and species of bees. Numerous studies found versatile pharmacological activities of propolis: antimicrobial, antifungal, antiviral, antioxidant, anticancer, anti-inflammatory, immunomodulatory, etc. In this review, the composition and biological activities of propolis are presented from a point of view of the origin and standardization of propolis for the purpose of the development of new pharmaceutical products on its base. It was revealed that some types of propolis, especially European propolis, contain flavonoids and phenolic acids, which could be markers for the standardization and quality evaluation of propolis and its preparations. One more focus of this paper was the overview of microorganisms’ sensitivity to propolis for further development of antimicrobial and antioxidant products for the treatment of various infectious diseases with an emphasis on the illnesses of the oral cavity. It was established that the antimicrobial activity of different types of propolis is quite significant, especially to Gram-negative bacteria and lipophilic viruses. The present study could be also of interest to the pharmaceutical industry as a review for the appropriate design of standardized propolis preparations such as mouthwashes, toothpastes, oral drops, sprays, creams, ointments, suppositories, tablets, and capsules, etc. Moreover, propolis could be regarded as a source for the isolation of biologically active substances. Furthermore, this review can facilitate partially overcoming the problem of the standardization of propolis preparations, which is a principal obstacle to the broader use of propolis in the pharmaceutical industry. Finally, this study could be of interest in the area of the food industry for the development of nutritionally well-balanced products. The results of this review indicate that propolis deserves to be better studied for its promising therapeutic effects from the point of view of the connection of its chemical composition with the locality of its collection, vegetation, appropriate extraction methods, and standardization.

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Section: Biologically Active Compounds Presented In Propolismentioning

confidence: 99%

Section: Main Biological Propertiesmentioning

confidence: 99%

Section: Representatives Propolis Type Referencementioning

confidence: 99%

Section: Geopropolis Frommentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemical Variability and Pharmacological Potential of Propolis as a Source for the Development of New Pharmaceutical Products

et al. 2022

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Physiological roles of propolis and red ginseng nanoplatforms in alleviating dexamethasone-induced male reproductive challenges in a rat model

Aziz,

Abdel-Wahab,

Abdel-Razik

et al. 2024

Mol Biol Rep

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Background Red ginseng and propolis are well-known antioxidants that have been related to a reduction in oxidative stress. Objective This study evaluated the efficiency of red ginseng and propolis, either in powder or as nano-forms against dexamethasone—induced testicular oxidative challenges in adult male albino rats. Methods Forty rats were divided into 8 equal groups including control negative group that was given vehicle (DMSO), control positive group that was administered dexamethasone in addition to the nano-propolis, nano-ginseng, nano-propolis + dexamethasone, nano ginseng+dexamethasone, propolis+dexamethasone and ginseng + dexamethasone groups. Serum, semen and tissue samples were obtained. Results Lower testosterone levels, higher levels of MDA, and lower levels of total antioxidant capacity in serum, as well as impaired semen quality and a disturbed histopathological picture of both the testis and seminal glands, were all observed as significant negative effects of dexamethasone. These findings were confirmed by lower gene expression profiles of CYP11A1, StAR, HSD-3b, Nrf-2 and ACTB-3b in testicular and seminal gland tissues. The most powerful anti-dexamethasone effects were obtained with either propolis in nanoform or conventional ginseng. Conclusion Propolis nano-formulation and ginseng in conventional form could be considered excellent candidates to ameliorate the oxidative stress provoked by dexamethasone, however, neither nano-ginseng nor conventional propolis showed such effects.

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Ameliorative Effect of Chitosan-Propolis Nanoparticles on the Estradiol Valerate -Induced PCOS in Rat

Hosseini¹,

Khodaei²,

Hasansagha³

et al. 2023

Preprint

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Background: Endocrine conditions that impact women define polycystic ovary syndrome. Previous studies have demonstrated a connection between PCOS and insulin intolerance, oxidative stress, and immune system dysfunction. Additionally, some reports have indicated that propolis has antioxidant properties and that chitosan nanoparticles have beneficial effects on the reproductive system. The goal of the present study is to compare metformin (Met) to chitosan-propolis nanoparticles and explain how they protect against a rat PCOS model caused by estradiol valerate (EV). (as a control treatment). Methods: In order to cause PCOS in rodents, a single subcutaneous injection of estradiol valerate was used, followed by a 42-day oral administration of 500 mg/kg of chitosan-propolis nanoparticles. Four sets of rats were created: the control, PCOS, metformin (PCOS and 150 mg/kg metformin), and chitosan-propolis nanoparticle (PCOS and 500 mg/kg chitosan-propolis nanoparticle) groups. The histopathological examination of the ovaries and measurement of serum ferctors were performed on all of the animals. Estradiol valerate caused PCOS, but chitosan-propolis nanoparticle therapy reversed it. Results: After chitosan-propolis nanoparticle intervention, the body weight and ovarian morphology had improved, and the serum biochemical parameters, including esretogen, progestron, vitamin D, calcium, and the insulin resistance index, had been corrected. These EV-induced changes include decreased SOD activity, elevated MDA levels, and evidence that oxidative stress was increased by EV when chitosan-propolis nanoparticle/Met were administered for 42 straight days. Additionally, certain relative mRNA transcripts, including those for the MCP, IL18, and CRP genes, were markedly upregulated in EV-treated animals. These findings unequivocally demonstrate the beneficial effects of chitosan-propolis nanoparticles/Met in inflammatory disorders. Conclustion: Together, the study's end findings, which are presented here, are consistent with the hypothesis that chitosan-propolis nanoparticle/Met offered protective activity against the harmful effects of EV. Although ameliorative effects may have been implicated, the primary pathway or pathways still need to be clarified.

show abstract

The in-vivo assessment of Turkish propolis and its nano form on testicular damage induced by cisplatin

Cited by 7 publications

References 60 publications

Chemical Variability and Pharmacological Potential of Propolis as a Source for the Development of New Pharmaceutical Products

Chemical Variability and Pharmacological Potential of Propolis as a Source for the Development of New Pharmaceutical Products

Physiological roles of propolis and red ginseng nanoplatforms in alleviating dexamethasone-induced male reproductive challenges in a rat model

Ameliorative Effect of Chitosan-Propolis Nanoparticles on the Estradiol Valerate -Induced PCOS in Rat

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