The in vivo anti-leukemia activity of N-(1-Pyrenlyl) maleimide in a bioluminescent mouse model

Chen, Chi-Yuan; Chang, Pei-Chi; Wang, Tong Hong; Wang, Tzu-Chien V.

doi:10.1016/j.leukres.2017.09.004

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Wells containing medium only were used to detect background fluorescence. Photon counts per second were recorded using an IVIS100 (Xenogen, Alameda, CA) imaging system [21].…”

Section: In Vitro Bioluminescence Imagingmentioning

confidence: 99%

“…The SAS-Luc cells (3 x 10 5 ) were injected into the tongue of nude mice. Bioluminescence imaging was done with an IVIS100 imaging system and performed as described previously [21]. The mice were randomly divided into groups of seven (n=7) and drug treatment was commenced three days after tumor implantation, a time when the orthotopically implanted tumors could be detected by the bioluminescence imaging in all mice.…”

Section: A Bioluminescent Mouse Model For Orthotopically Implanted Osccmentioning

confidence: 99%

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2-O-Methylmagnolol Induces Apoptosis and Inhibits IL-6/STAT3 Signaling in Oral Squamous Cell Carcinoma

Wang

Fang

et al. 2018

Cell Physiol Biochem

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Background/Aims: 2-O-methylmagnolol (MM1), a derivative of magnolol bearing one methoxy moiety, has been shown to display improved anti-tumor activity against skin cancers. In this study, we examined the anti-tumor effects of magnolol and MM1 on oral squamous cell carcinoma (OSCC). Methods: Trypane blue staining and clonogenic assays were performed to determine the cytotoxic effects of magnolol and MM1 in OSCC cells. Migration and matrigel invasion assays were carried out to examine the metastasis effects of magnolol and MM1 in OSCC cells. IL6-stimulation, Western blot, and immunohistochemistry were used to investigate the IL-6/STAT3 signaling and apoptosis. A bioluminescent mouse model of orthotopically implanted SAS cells was used to determine the anti-tumor activity of MM1 in vivo. Results: MM1 displays greater activity than magnolol on affecting the cytotoxicity, migration, and invasion of OSCC cells cultured in vitro. The improved anti-tumor activity of MM1 was shown to associate with its greater activity to inhibit STAT3 signaling and to induce apoptosis in the OSCC. In addition, we presented evidence that MM1 is effective in inhibiting the growth of orthotopic implanted OSCC cells in vivo. Conclusion: Our data indicate that MM1 displays greater anti-tumor activity than magnolol in OSCC and is an attractive agent to be further explored for its potential clinical application.

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“…Wells containing medium only were used to detect background fluorescence. Photon counts per second were recorded using an IVIS100 (Xenogen, Alameda, CA) imaging system [21].…”

Section: In Vitro Bioluminescence Imagingmentioning

confidence: 99%

Section: A Bioluminescent Mouse Model For Orthotopically Implanted Osccmentioning

confidence: 99%

2-O-Methylmagnolol Induces Apoptosis and Inhibits IL-6/STAT3 Signaling in Oral Squamous Cell Carcinoma

Wang

Fang

et al. 2018

Cell Physiol Biochem

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“…Viability was assayed by staining with trypan blue and/or MTT, as described previously [ 19 ]. Combination index (CI) values were calculated to define the synergistic or additive effects of treatment as previously described [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin

et al. 2021

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Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are approved treatments for non-small-cell lung cancer (NSCLC) patients harboring activating EGFR mutations. The EGFR C797S mutation is one of the known acquired-resistance mutations to the latest third-generation TKIs. At present, there are no clear options for treating patients who acquire resistance to third-generation TKIs. The acquisition of the EGFR C797S mutation was shown to upregulate the expression of AXL, a receptor tyrosine kinase of the TAM (TYRO3-AXL-MER) family, and the suppression of AXL is effective in reducing the growth of NSCLC cells harboring EGFR C797S. As quercetin was recently shown to inhibit AXL, quercetin may be effective in treating NSCLC cells harboring the EGFR C797S mutation. In this work, the cytotoxic effects of quercetin and its ability to inhibit tumor growth were examined in TKI-resistant NSCLC cells harboring the EGFR C797S mutation. We demonstrated that quercetin exhibited potent cytotoxic effects on NSCLC cells harboring the EGFR C797S mutation by inhibiting AXL and inducing apoptosis. Quercetin inhibited the tumor growth of xenografted NSCLC cells harboring the EGFR C797S mutation and appeared to act synergistically with brigatinib to inhibit of tumor growth in vivo. In summary, herein, we revealed that quercetin is an effective inhibitor for the treatment of non-small-cell lung cancer harboring the EGFR C797S mutation.

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Crystal structure, Hirshfeld surface analysis and DFT study of N-(2-nitrophenyl)maleimide

Montoya-Garcia,

Cortes-Hernandez,

D'Vries

et al. 2024

Acta Cryst E

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The title compound [systematic name: 1-(2-nitrophenyl)pyrrole-2,5-dione], C10H6N2O4, crystallizes in the monoclinic system (space group P21/n) with two molecules in the asymmetric unit, which are linked by C—H...O hydrogen bonds. Hirshfeld surface analysis showed that the most significant contributions to the crystal packing are from H...O/O...H, H...C/C...H and H...H interactions, which contribute 54.7%, 15.2% and 15.6%, respectively. A DFT study was conducted using three different levels of theory [(B3LYP/6–311+G(d,p), wB97XD/Def2TZVPP and LC-wpbe/6–311(2 d,2p)] in order to determine the stability, structural and electronic properties of the title molecule with a view to its potential applications and photochemical and copolymer properties.

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The in vivo anti-leukemia activity of N-(1-Pyrenlyl) maleimide in a bioluminescent mouse model

Cited by 3 publications

References 17 publications

2-O-Methylmagnolol Induces Apoptosis and Inhibits IL-6/STAT3 Signaling in Oral Squamous Cell Carcinoma

2-O-Methylmagnolol Induces Apoptosis and Inhibits IL-6/STAT3 Signaling in Oral Squamous Cell Carcinoma

Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin

Crystal structure, Hirshfeld surface analysis and DFT study of N-(2-nitrophenyl)maleimide

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