The in vitro resistance of oxidized hyaluronic acid to testicular hyaluronidase

Ponedel’kina, I. Yu.; Odinokov, V. N.; Saitgalina, E. A.; Джемилев, У. М.

doi:10.1134/s1607672907060142

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Cited by 4 publications

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“…[4]). The biodegradability of native LMW HA and HMW HA and phosphorylated HA-P samples was determined by the amount of low-molecular-weight products formed during the cleavage of HA by HA-ase (60 or 600 ME/mL, [HA] = 4 mg/mL of citrate buffer, pH 6.3, 16-18 h) and not precipitated by the methyl alcohol/diethyl ether mixture (3:1) [2]. The relative biodegradability (RB) of HA-P samples was calculated relative to the biodegradability of the corresponding LMW HA and HMW HA.…”

Section: O5mentioning

confidence: 99%

“…Any chemical modification of HA can lead to both a decrease and an increase in biodegradability. For example, the cross-linking of HA [1] or C6-oxidation at the N-acetyl-D-glucosamine unit [2] reduces its biodegradability, while the introduction of vitamin substances such as nicotinic acid (vitamin PP) into the structure activates the biodegradability of HA macromolecules [3].…”

Section: Introductionmentioning

confidence: 99%

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