Abstract:blasts (Kolar et al., 2010). Particularly MSCs are considered to play a pivotal role in an adequate healing process, since they are able to differentiate into both chondrocytes and osteoblasts/osteocytes, thereby facilitating bone healing (Knight and Hankenson, 2013). The transcription factor runt-related transcription factor (RUNX2) drives MSCs towards the osteogenic lineage, while its secreted downstream target phosphoprotein 1 (SPP1) is a key marker for early osteogenesis and is also induced by hypoxia-indu… Show more
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