The in vitro elution characteristics of vancomycin combined with imipenem-cilastatin in acrylic bone–cements: A pharmacokinetic study

Cerretani, Daniela; Giorgi, Gianluca; Fornara, Paolo; Bocchi, L; Neri, Laura; Ceffa, Remo; Ghisellini, F; Ritter, Merrill A.

doi:10.1054/arth.2002.32184

Cited by 78 publications

(78 citation statements)

References 22 publications

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“…Our finding was also supported by previous studies of PMMA/gelatin/antibiotic constructs used for craniofacial tissue materials [20]. It should also be noted that the decrease of the bending strength was detected within a relatively narrower range of particle density and size than what was reported in the literature as our cement mixture was designed to be injectable [20,30,31].…”

Section: Discussionsupporting

confidence: 88%

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Biomechanical characteristics of cement/gelatin mixture for prevention of cement leakage in vertebral augmentation

et al. 2013

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Purpose This study evaluated whether or not the addition of gelatin micro-particles into the polymethyl methacrylate (PMMA) could reduce cement infiltration in cancellous bone of vertebra. Methods Gelatin micro-particles were prepared in various sizes and mixed with PMMA in different densities. Dynamic viscosity of the mixture was measured by a rotational rheometer. Fresh bovine vertebral bodies were sectioned into cylindrical samples. Permeability of the mixture through the samples was tested on a mechanical test machine, and calculated using Darcy's law. The PMMA/gelatin mixture also underwent compressive and bending tests, and their structures were examined by scanning electron microscopy. Results The cement/gelatin mixture increased the viscosity. Significant reduction of cement permeability in cancellous bone was determined after the addition of the micro-particles. Micro-particles of 2 % in density and 125-250 lm in size decreased the permeability by 1/3 without any significant change of the cement viscosity. The biomechanical strength was unchanged in compression but decreased by up to 20 % in bending. Conclusions Gelatin micro-particles significantly increased the cement viscosity, reduced the permeability in cancellous bone of vertebra, decreased the flexural strength, but did not affect the compressive strength. Although it suggested a manageable approach in vertebral augmentation, the outcome should be further verified on a cadaveric model or an animal model before the mixture could be used safely and effectively in the clinical treatment.

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Section: Discussionsupporting

confidence: 88%

“…Gelatin micro-particles could also be mixed with antibiotic or other therapeutic agents to promote regenerated tissue constructs and to achieve local controlled drug release [18][19][20]. The early clinical study showed reduction of 50 % leakage after the gelatin addition [1].…”

Section: Introductionmentioning

confidence: 99%

Biomechanical characteristics of cement/gelatin mixture for prevention of cement leakage in vertebral augmentation

et al. 2013

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“…There still is no agreement concerning the choice or dose of the antibiotic to be mixed with the cement (Cerretani et al, 2002), as can be seen from the numerous published reports concerning vancomycin (Brien et al, 1993;Cerretani et al, 2002;Baleani et al, 2008), gentamicin, tobramycin (Brien et al, 1993)cephalosporins, clindamycin, ticarcillin, ciprofloxacin, amikacin, meropenem (Baleani et al, 2008), imipenem -cilastin (Cerretani et al, 2002) daptomycin and several others (Hanssen and Spangehl, 2004). Increasing bacterial resistance against common antibiotics, especially gentamycin, has lead to a demand for alternative drugs (Brien et al, 1993;Baleani et al, 2008;Hanssen and Spangehl, 2004;Hanssen, 2004).…”

Section: Ideal Antibiotic Dose and Bone Cementmentioning

confidence: 99%

Antibiotic Loaded Acrylic Bone Cement in Orthopaedic Trauma

Samuel¹

2012

Osteomyelitis

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“…Several methods [6][7][8][9] of local antibiotic delivery system using PMMA are being commonly used which includes hand fashioned or commercially available PMMA beads, 10 PMMA rods [11][12][13] and PMMA coated nails. [1][2][3][4] None of these methods provide adequate stability and necessitates secondary procedure for stability at the fracture site in form of intramedullary interlocking nailing, cephalomedullary nailing or LCP with or without autogenous bone grafting.…”

Section: Introductionmentioning

confidence: 99%

A simple method for fashioning an antibiotic impregnated cemented rod for intramedullary placement in infected non-union of long bones

Bharti

Saroj²,

Kumar

et al. 2016

Journal of Clinical Orthopaedics and Trauma

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The in vitro elution characteristics of vancomycin combined with imipenem-cilastatin in acrylic bone–cements: A pharmacokinetic study

Cited by 78 publications

References 22 publications

Biomechanical characteristics of cement/gelatin mixture for prevention of cement leakage in vertebral augmentation

Biomechanical characteristics of cement/gelatin mixture for prevention of cement leakage in vertebral augmentation

Antibiotic Loaded Acrylic Bone Cement in Orthopaedic Trauma

A simple method for fashioning an antibiotic impregnated cemented rod for intramedullary placement in infected non-union of long bones

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