The in vitro and in vivo evaluation of new synthesized prodrugs of 5-OH-DPAT for iontophoretic delivery

MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer

“…Issues which must be addressed include: i) the hybridizationdependent and -independent off-target effects, ii) the hepatotoxicity and other associated toxicities, iii) immunomodulatory effects, iv) the design of efficient delivery systems, v) the rapid clearance by the reticulo-endothelial system, vi) the enhancement of circulation time when injected into the bloodstream, vii) the delivery to metastases and vii) the endosomal escape (161)(162)(163). Fast renal clearance can be prevented by coupling miRNA with polyethylene glycol (PEG), albumins or cholesterol, which mediate shielding from renal clearance (164)(165)(166). Shielding of nucleic acids ameliorates their immuno-genicity and their potential to activate a cytokine release syndrome (167).…”

Impact of Ester Promoieties on Transdermal Delivery of Ketorolac

“…KB liberated less parent drug in plasma than did other prodrugs, suggesting that the aromatic ring may retard the docking of KB to esterases in the presence of plasma. In vivo skin metabolism is found to be greater than in vitro conditions . Therefore, we predict that the ester prodrugs of ketorolac can be largely hydrolyzed after penetrating into skin.…”

Engineering of peglayted camptothecin into core–shell nanomicelles for improving solubility, stability and combination delivery

“…This strategy is like the popular prodrugs of drug-polymer conjugates, 12 in which polymers were bio-reversibly modied by drug molecules, thus producing enhanced drug solubility and entrapment efficiency, releasing drugs in a controlled manner and minimizing the carrier content. 13 Although many prodrugs have been developed, [14][15][16] showing improved therapeutic index, the method is not optimal for CPT because most of prodrugs exposure to physiological conditions will make CPT ineffective due to its low stability. 17 For the intrinsic hydrophobic properties of CPT, PEGylated CPT prodrugs could be further prepared into carriers, such as liposome, to enhance the stability of CPT.…”