The In Vitro and In Vivo Activity of Ciprofloxacin

Zeiler, H.-J.; Grohe, Klaus

doi:10.1007/978-3-663-01930-5_3

Cited by 15 publications

(12 citation statements)

References 5 publications

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“…Ciprofloxacin is an antibiotic used for the treatment of bacterial infections, belonging to the fluoroquinolones class . The mode of action of this drug encompasses the inhibition of prokaryotic DNA gyrase, but its influence on vertebrate DNA enzymes is several orders of magnitude weaker .…”

Section: Introductionsupporting

confidence: 78%

Embryonic development, locomotor behavior, biochemical, and epigenetic effects of the pharmaceutical drugs paracetamol and ciprofloxacin in larvae and embryos of Danio rerio when exposed to environmental realistic levels of both drugs

Nogueira

Pinto

Correia

et al. 2019

Environmental Toxicology

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For several years, the scientific community has been concerned about the presence of pharmaceuticals in the wild, since these compounds may have unpredictable deleterious effects on living organisms. Two examples of widely used pharmaceuticals that are present in the environment are paracetamol and ciprofloxacin. Despite their common presence in the aquatic environment due to their poor removal by sewage treatment plants, knowledge concerning their putative toxic effects is still scarce. This work aimed to characterize the effects of paracetamol (0.005, 0.025, 0.125, 0.625, and 3.125 mg/L) and ciprofloxacin (0.005, 0.013, 0.031, 0.078, 0.195, and 0.488 μg/L) in zebrafish embryos and larvae, exposed to environmentally relevant levels, close to the real concentrations of these pharmaceuticals in surface waters and effluents. The adopted toxic end points were developmental, a behavioral parameter (total swimming time), and a biomarker‐based approach (quantification of the activities of catalase, glutathione‐S‐transferase, cholinesterases, glutathione peroxidase, and lipid peroxidation levels) combined with epigenetic analysis (immunohistochemical detection of 5‐methylcytidine). Exposure to paracetamol had effects on all of the adopted toxic end points; however, ciprofloxacin only caused effects on behavioral tests and alterations in biomarkers. It is possible to ascertain the occurrence of oxidative stress following exposure to both drugs, which was more evident regarding paracetamol, an effect that may be related to the observed epigenetic modifications.

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Section: Introductionsupporting

confidence: 78%

Embryonic development, locomotor behavior, biochemical, and epigenetic effects of the pharmaceutical drugs paracetamol and ciprofloxacin in larvae and embryos of Danio rerio when exposed to environmental realistic levels of both drugs

Nogueira

Pinto

Correia

et al. 2019

Environmental Toxicology

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“…In Costa Rica the high resistance rates found can be explained based on an indiscriminate and frequent use of common antibiotics such as amoxycillin and first and second generation cephalosporines, the non-efficient control practices of hospitalary infections and a limited medicinal vigilance by health authorities. At the same time, the low resistance rates to agents such as imipenem and ciprofloxacine can be explained by in its low consumption and later appearance in the market (22). The resistance rates obtained by the Kirby-Bauer method and ATB antibiogram show no statistical difference between the techniques, the slight differences between both are due to the fact that ATB antibiogram generally uses antibiotics in pairs.…”

Section: Discussionmentioning

confidence: 96%

Patrón de sensibilidad a antibióticos de bacterias Gram negativas aisladas a partir de fórmulas enterales

Arias¹,

Monge²,

Artavia³

et al. 2000

Rev Biomed

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Introducción. Las fórmulas enterales contaminadas representan un riesgo para el desarrollo de infecciones nosocomiales y de pacientes hospitalarios. El objetivo de este estudio fue identificar 75 cepas de bacilos Gram negativos, aislados a partir de fórmulas enterales, distribuidas en los tres mayores centros hospitalarios costarricenses y evaluar su patrón de sensibilidad a los antibióticos. Material y métodos. Se utilizaron dos técnicas diferentes para el desarrollo del proyecto: la técnica modificada de Kirby Bauer y la técnica ATB antibiograma (Biomériaux®). Resultados. A partir de las muestras analizadas, los grupos predominantes fueron Aeromonas sp., (22,7%), Klebsiella sp. y Proteus sp. (18,7% cada una) y Enterobacter sp. (4%). De acuerdo a los patrones de sensibilidad a los antibióticos obtenidos usando la técnica de Kirby-Bauer modificada, 36% de las cepas mostraron resistencia a amoxicilinaácido clavulánico, 25,3% a cefaclor y 14,7% a cefuroxime. Todas las cepas fueron sensibles a imipenem y ciprofloxacina. Utilizando la técnica ATB antibiograma, las bacterias mostraron resistencia a la amoxicilina (74,6%), amoxicilinaácido clavulánico (34,6%), ticarcilina-cefalotina (22,6%) y piperacilina (2,6%). Todas las cepas fueron sensibles a los otros diez antibióticos evaluados. Conclusiones. Es urgente asegurar una higiene estricta durante la preparación y manejo de las soluciones enterales utilizadas en los hospitales, de manera que no representen un foco potencial de contaminación con bacterias resistentes que puedan limitar la recuperación de los pacientes.

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“…It is also affected by the state of host defences (Bodey, Feld & Burgess, 1976) and environmental factors present at the infection site (Bryant & Hammond, 1974;Zeiler, 1985). Experimental local or systemic infection models are often used to evaluate the potential in-vivo efficacy of antimicrobial agents (Zeiler & Grohe, 1984;Heifetz et al, 1988). Although there are some disadvantages and variability inherent in these screening models (Barza, 1978), their predictive ability has, generally, been good (Miraglia, 1976;Bergeron, 1978).…”

Section: Discussionmentioning

confidence: 99%

Comparative chemotherapeutic activity of temafloxacin, cefoxitin, clindamycin, imipenem and ampicillin/sulbactam against Bacteroides fragilis in a mouse subcutaneous abscess model

Alder

Clement

1993

J Antimicrob Chemother

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The new fluorinated 4-quinolone temafloxacin was compared with cefoxitin, clindamycin, imipenem (with or without cilastatin) and ampicillin/sulbactam in a mouse subcutaneous abscess model of Bacteroides fragilis infection. Based upon in-vitro susceptibility data, temafloxacin may represent an effective oral and parenteral alternative to standard oral and parenteral anti-anaerobic agents currently in use. Temafloxacin therapy with dosage regimens of < 200 mg/kg/day typically yielded 2-3 x log10 reductions in cfu/abscess, similar to ampicillin/sulbactam, while cefoxitin and clindamycin were generally unable to produce similar reductions at doses up to 400 mg/kg/day. Imipenem (with or without cilastatin) was unable to produce a 1 x log10 reduction at doses of 400 mg/kg/day. This study suggests that temafloxacin has potential for the treatment of anaerobic or mixed aerobic-anaerobic infections in man.

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The In Vitro and In Vivo Activity of Ciprofloxacin

Cited by 15 publications

References 5 publications

Embryonic development, locomotor behavior, biochemical, and epigenetic effects of the pharmaceutical drugs paracetamol and ciprofloxacin in larvae and embryos of Danio rerio when exposed to environmental realistic levels of both drugs

Embryonic development, locomotor behavior, biochemical, and epigenetic effects of the pharmaceutical drugs paracetamol and ciprofloxacin in larvae and embryos of Danio rerio when exposed to environmental realistic levels of both drugs

Patrón de sensibilidad a antibióticos de bacterias Gram negativas aisladas a partir de fórmulas enterales

Comparative chemotherapeutic activity of temafloxacin, cefoxitin, clindamycin, imipenem and ampicillin/sulbactam against Bacteroides fragilis in a mouse subcutaneous abscess model

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