“…Finding endogenous compounds within the brain that play a role in inhibiting protein aggregation may be the starting point in the design of future therapeutics. 28,29 Epinephrine (commonly known as adrenaline, EP for short), as a vital human endogenous small molecule, has been found to be able to influence Tau aggregation. 17,19 EP is secreted by the medulla of the adrenal glands that helps to transmit messages between nerve cells, and plays a key role in the fight-or-flight response by increasing the heart rate, vasodilatation and blood sugar.…”