The (in)adequacy of translational research in dentistry

Faggion, Clóvis Mariano

doi:10.1111/eos.12684

Cited by 8 publications

(6 citation statements)

References 56 publications

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“…According to translational research in dentistry, analytical epidemiological studies, of the type of the present case–control study, should have the ultimate goal of producing more meaningful and applicable results that serve to improve people's health (Faggion, 2020). Therefore, dentists should translate the results of this study, along with those of others previously published (Nijakowski et al, 2021; Piras et al, 2017; Poyato‐Borrego et al, 2020, 2021), into the dental clinic.…”

Section: Discussionmentioning

confidence: 99%

Periapical and endodontic status of patients with inflammatory bowel disease: Age‐ and sex‐matched case–control study

et al. 2022

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Aim: Crohn's disease (CD) and ulcerative colitis (UC) are two chronic recurrent inflammatory processes of the gastrointestinal tract, grouped under the name inflammatory bowel disease (IBD), causing clinical episodes of intestinal inflammation.The aim of this study was to investigate the possible association between IBD and the prevalence of apical periodontitis (AP) and root canal treatment. Methodology:A case-control study design matched to age and sex was used. The study group (SG) included 28 patients with IBD (13 with CD, 15 with UC). Another 28 healthy subjects, without IBD and age-and sex-matched, were included in the control group (CG). Radiographic records were analysed and AP was diagnosed as radiolucent periapical lesions (RPLs), using the periapical index score. Student's ttest, χ 2 test and multivariate logistic regression were used in the statistical analysis.

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Section: Discussionmentioning

confidence: 99%

Periapical and endodontic status of patients with inflammatory bowel disease: Age‐ and sex‐matched case–control study

et al. 2022

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“…Given how harms are considered in medical 49,50 and dental research, 51,52 as well as in the introduction of new disease definitions in medicine, 3,10 this neglect of possible harms was not a surprise. Related to the periodontitis classification, a few potential harms of the new classification system could nonetheless have been considered.…”

Section: What Is the Incremental Harm For Patients Classified By The ...mentioning

confidence: 99%

Justification for the 2017 periodontitis classification in the light of the Checklist for Modifying Disease Definitions: A narrative review

Raittio

Bælum

2023

Comm Dent Oral Epid

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Once a while, disease classifications have needed revision because new knowledge has accumulated, and new technologies and better treatments have emerged. Changes made to disease classifications should be trustworthy and openly justified. The periodontitis definition and classification system was changed in 2017 by the ‘World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions’. The workshop, comprising clinicians and researchers, resulted in the production of a 23‐article special issue that introduced the new definitions and classifications of periodontitis. In this narrative review, we critically review how the changes made to the periodontitis definition and classification were justified in the light of the Checklist for Modifying Disease Definitions. Under each of the eight items of the checklist, we have discussed how the item was or could have been considered in the light of the checklist and its guidance. In our view, the new definition and classification of periodontitis was presented in an understandable way, even though the changes from the previous definition were not made visible. However, the issues of (1) estimated changes in prevalence or incidence, (2) triggers for the change, (3) prognostic ability, (4) repeatability or reproducibility, (5) incremental benefits, (6) incremental harms or (7) net benefits and harms related to the introduction of new classification were not considered in the way suggested in the checklist. Thereby, a balanced assessment of potential benefits and harms associated with the new periodontitis classification system was not presented, and to a large extent it remains unknown if the use of the new classification system will provide more net benefits to patients and to the community than previous systems. It is our view that patients and societies deserve transparent and balanced assessments of the potential benefits and harms associated with the periodontitis classification. Importantly, these should reflect the values and preferences also of the patients and the wider community and consider the impact on resource usage.

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“…According to the "translational research concept", the ultimate goal of research should be conducting studies with the highest methodological quality possible to obtain accurate and useful information for researchers, clinicians and patients [62]. Within this context, clinicians and researchers should consider the current results with particular attention to promote high-quality research on this emerging topic.…”

Section: Limitations and Implications For Researchmentioning

confidence: 99%

Effectiveness of probiotics in apical periodontitis progression: A scoping review and implications for research

Rosa¹,

Pedullà²

2022

Aust Endodontic J

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To synthesise the current knowledge on the effects of probiotics in apical periodontitis progression by a scoping review of animal and human studies. Reporting was based on Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) Extension for Scoping Reviews. The literature search and screening was performed on PubMed and Scopus databases by two independent reviewers selecting human and animal studies that evaluated the effectiveness of probiotics in reducing the severity of apical periodontitis. Two animal studies with 3 publications met the eligibility criteria for qualitative synthesis. The most common probiotics were Lactobacillus rhamnosus and Lactobacillus acidophilus orally administered for gavage in Wistar rats with induced apical periodontitis. Overall, probiotics significantly reduced inflammation and bone resorption with an improvement in the apical periodontitis progression. Although results in animal studies are promising, the use of probiotics in apical periodontitis progression requires caution due to the insufficient available evidence.

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The (in)adequacy of translational research in dentistry

Cited by 8 publications

References 56 publications

Periapical and endodontic status of patients with inflammatory bowel disease: Age‐ and sex‐matched case–control study

Periapical and endodontic status of patients with inflammatory bowel disease: Age‐ and sex‐matched case–control study

Justification for the 2017 periodontitis classification in the light of the Checklist for Modifying Disease Definitions: A narrative review

Effectiveness of probiotics in apical periodontitis progression: A scoping review and implications for research

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