The impurity characteristics of methamphetamine synthesized by Emde and Nagai method

Isotope fractionation during precipitation of methamphetamine HCl and discrimination of seized forensic samples

“…Methamphetamine is commonly synthesized from either (À)-ephedrine/(+)-pseudoephedrine [5,8,[11][12][13][14][15][16][17][18][19][20] or phenyl-2-propanone [9,11,14,21]. Synthesis from either of the ephedrine-type precursors is most common in New Zealand and in the South East Asia region.…”

Use of stable isotope ratios for profiling of industrial ephedrine samples: Application of hydrogen isotope ratios in combination with carbon and nitrogen

“…Impurity analysis and enantiomer profiling of methamphetamine have been used to enable the identification of the synthetic route and precursor for many seized methamphetamines [2][3][4][5]. Route-specific impurities can be detected by HPLC and GC/MS.…”

GC-MS: herramienta fundamental para el análisis de drogas de uso ilícito

“…En el primer caso quedan residuos de cloroefedrina y en el segundo caso, las impurezas comunes son 1,3-dimetil-2--fenilnaftaleno y 1-bencil-3-metilnaftaleno. El análisis GC-MS de metanfetaminas decomisadas en Korea permitió establecer que el 80% de las muestras provino del método sintético de Emde y que en los 2 años previos aumentó en 30% el número de muestras sintetizadas por el método de Nagai [15] .…”