The Improvement of Ischemia/Reperfusion Injury by Erythropoetin Is Not Mediated Through Bone Marrow Cell Recruitment In Rats

Esposito, Ciro; Pertile, Enrico; Grosjean, Fabrizio; Castoldi, Francesca; DiLiberto, R.; Serpieri, Nicoletta; Arra, Mariarosa; Villa, Luigi; Mangione, Filippo; Esposito, Vittoria; Migotto, C.; Valentino, Rossella; Canton, Antonio Dal

doi:10.1016/j.transproceed.2009.03.008

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Furthermore, our results showed that the pretreatment with rhEPO was the most effective in preventing damages caused by Cisp. This is in accord with Esposito et al, 44 who demonstrated that EPO preconditioning was effective to protect kidney against ischemia/reperfusion injury by reducing both tubular cell injury and interstitial infiltration.…”

Section: Resultssupporting

confidence: 89%

Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-Induced Oxidative Stress and Nephrotoxicity in Rat Kidney

et al. 2011

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Cisplatin (Cisp) is one of the most widely used chemotherapeutic agents for the treatment of several human malignancies. The efficacy of Cisp is dose dependent and at higher doses serious kidney injury may occur. Recombinant human erythropoietin (rhEPO) has recently been shown to exert an important cytoprotective effect in experimental brain injury and ischemic acute renal failure. The aim of the present study was to explore whether rhEPO administration is protective against Cisp-induced oxidative damage and renal injury. Our results showed that Cisp induced a marked oxidative stress and renal failure. Administration of rhEPO (pre-, co- or postadministration with regard to Cisp) decreased oxidative damage induced by Cisp. Recombinant human EPO reduced malondialdehyde and protein carbonyl levels. Recombinant human EPO also prevented glutathione depletion and ameliorated the increased catalase activity induced by Cisp treatment. Furthermore, rhEPO restored creatinine and blood urea nitrogen levels increased by Cisp. We concluded that rhEPO administration especially in pretreatment condition protected rats against Cisp-induced renal oxidative stress and nephrotoxicity.

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Section: Resultssupporting

confidence: 89%

Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-Induced Oxidative Stress and Nephrotoxicity in Rat Kidney

et al. 2011

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“…Furthermore, it demonstrated that the pretreatment condition was the most efficient in preventing this renal dysfunction caused by Cisp. This is in accord with Esposito et al 34 who demonstrated that rhEPO preconditioning is effective in protecting the kidney against ischemia/ reperfusion injury by reducing both tubular cell injury and interstitial infiltration.…”

Section: Discussionsupporting

confidence: 89%

“…In fact, the regeneration of renal tubular cells starts between day 6 and day 10 of exposure to toxic agents. 34,35 The measure of liver weight demonstrated that Cisp caused a loss in liver weight as compared to the control group and an increase in serum levels of ALT, ALT, GGT, ALP, BILD and BILT, which are the indicators of hepatotoxicity. These results are in agreement with studies showing that Cisp caused a liver toxicity characterized by an elevation of ALT, ALT, GGT, ALP, BILD and BILT levels in seum.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of recombinant human erythropoietin against cisplatin-induced renal and hepatic dysfunctions in Wistar rats

et al. 2012

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Cisplatin (Cisp) is one of the most effective chemotherapeutic drugs. However, the dose of Cisp is greatly limited by its toxicity. Recombinant human erythropoietin (rhEPO), a hormone that regulates hematopoiesis, has also been shown to exert tissue-protective effects. The purpose of this study was to explore the protective effect of rhEPO against Cisp-induced renal and liver dysfunctions. Adult male Wistar rats were divided into six groups of six each: control, rhEPO-alone group, Cisp-alone group and rhEPO + Cisp group (pretreatment, cotreatment and posttreatment conditions). Our results showed that Cisp-induced a marked renal and liver failure characterized by a significant decrease in body weight, organ weight and organ ratio and a significant increase in creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, G-glutamyl transferase, alkaline phosphatase, bilirubin conjugated and bilirubin total levels in serum. Histological examination showed that Cisp caused kidney alterations. rhEPO treatments restored body weight, organ weight and organ ratio as well as serum biochemical parameters changed due to Cisp exposure.

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“…Esposito et al 28 who demonstrated that rhEPO preconditioning is effective in protecting the kidney against ischemia/reperfusion injury by reducing both tubular cell injury and interstitial infiltration.…”

Section: Human and Experimental Toxicologymentioning

confidence: 99%

Role of recombinant human erythropoietin against mitomycin C-induced cardiac, hepatic and renal dysfunction in Wistar rats

et al. 2014

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Mitomycin C (MMC) is one of the most effective chemotherapeutic drugs. However, the dose of MMC is greatly limited by its toxicity in normal tissues. Recombinant human erythropoietin (rhEPO), an erythropoietic hormone, has also been shown to exert tissue protective effects. The purpose of this study was to explore the protective effect of rhEPO against MMC-induced heart, liver, and renal dysfunction. Adult male Wistar rats were divided into six groups (with six animals each), namely control, rhEPO alone group, MMC alone group, and rhEPO + MMC group (pre-, co-, and posttreatment conditions). The results showed that MMC induced a marked cardiac, renal, and liver failure characterized by a significant decrease in body weight, organs weight, and organs ratio and a significant increase in creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, and conjugated and total bilirubin levels in serum. Histological examination showed that MMC caused liver alterations. rhEPO treatment restored body weight, organs weight, and organs ratio as well as serum biochemical parameters and histological damage caused by MMC exposure.

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The Improvement of Ischemia/Reperfusion Injury by Erythropoetin Is Not Mediated Through Bone Marrow Cell Recruitment In Rats

Cited by 8 publications

References 10 publications

Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-Induced Oxidative Stress and Nephrotoxicity in Rat Kidney

Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-Induced Oxidative Stress and Nephrotoxicity in Rat Kidney

The protective effect of recombinant human erythropoietin against cisplatin-induced renal and hepatic dysfunctions in Wistar rats

Role of recombinant human erythropoietin against mitomycin C-induced cardiac, hepatic and renal dysfunction in Wistar rats

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