The Improvement of Hyperglycemia after RYGB Surgery in Diabetic Rats Is Related to Elevated Hypothalamus GLP-1 Receptor Expression

Zynat, Jazyra; Guo, Yutao; Lu, Yingli; Lin, Donghai

doi:10.1155/2016/5308347

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Local injection of GLP-1 into the arcuate nucleus of the hypothalamus reduces hepatic glucose production, and local injection of hypothalamic paraventricular nucleus inhibits food intake [14]. At the same time, it has been proved that the expression of GLP-1 receptor is up-regulated after gastric bypass (see figure 3), and the expression of GLP-1R mRNA in hypothalamus is negatively correlated with blood glucose level [15]. Peripheral glucose balance may be regulated by activation of the hypothalamic GLP-1R receptor after gastric bypass surgery.…”

Section: Glp-1-hindbrain-hypothalamusmentioning

confidence: 97%

Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus

Quan¹

2019

CMR

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To explore the role of blood glucose regulation in gastric bypass surgery is a hot point in the treatment of diabetes in recent years. Current evidence is very clear that the gastric bypass surgery is one of the most promising therapy to cure type 2 diabetes. However, the mechanisms are not yet understood. Studying the mechanism of surgical treatment can not only understand the pathogenesis of diabetes, but also have important scientific and practical significance for clinically and safely carrying out this therapy. As is known to all, the body's energy metabolism and glucose homeostasis are regulated by the hypothalamus. Thus, we summarize the process mechanism of central regulation of glucose homeostasis in post-surgery and find that the hypothalamus after gastric bypass surgery showed enhanced expression of peripheral signal receptors, enhancement of leptin signal and insulin signal, and expression changes of certain related genes, then issued neuroendocrine signals to control peripheral insulin sensitivity and glucose metabolism. Then, we prove that the improvement of peripheral metabolic status is caused by the decisive role of central regulation in post-surgery. These funding provide scientific basis to improve the understanding of the neuroendocrine mechanism of diabetes and the development of clinical implication of gastric bypass surgery.

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Section: Glp-1-hindbrain-hypothalamusmentioning

confidence: 97%

Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus

Quan¹

2019

CMR

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G protein-coupled receptors driven intestinal glucagon-like peptide-1 reprogramming for obesity: Hope or hype?

Patil,

Casari,

Warne

et al. 2024

Biomedicine & Pharmacotherapy

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Capsaicin has an anti-obesity effect through alterations in gut microbiota populations and short-chain fatty acid concentrations

Wang¹,

Tang²,

Tang³

et al. 2020

Food & Nutrition Research

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Background: Research on the association between breastfeeding duration and food neophobia is inconclusive. Breastfeeding and measures to reduce food neophobia are highly recommended to ensure a healthy diet early in life. Objective: The aim of this study was to evaluate the association between breastfeeding duration and food neophobia in young Norwegian children. Design: Participants (n = 246) were recruited through kindergartens in four Norwegian counties in 2017. The parents of 1-year-olds filled in questionnaires, including standardized questions on breastfeeding and food neophobia. Cross-sectional results are presented. Comparisons of child neophobia score at 16 months of age according to breastfeeding status at various timepoints during infancy were explored in linear regression models adjusted for maternal education and parental food neophobia. Results: Still being breastfed at 12 months and being exclusively breastfed at 5 months were independently associated with slightly higher food neophobia score at the mean age of 16 months compared to shorter duration of breastfeeding. We found no other associations between breastfeeding duration and child food neophobia. Discussion: Our study adds to the somewhat scarce literature regarding associations between breastfeeding mode and duration and later food neophobia; some literature shows protective relations between breastfeeding and food fussiness, and others report opposite or null findings. Conclusion: We found that both being breastfed at 12 months and being exclusively breastfed at 5 months were independently associated with slightly higher food neophobia score at the mean age of 16 months compared to shorter duration of breastfeeding. As the data are derived from a cross-sectional study, these findings should be interpreted with caution.

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The Improvement of Hyperglycemia after RYGB Surgery in Diabetic Rats Is Related to Elevated Hypothalamus GLP-1 Receptor Expression

Cited by 3 publications

References 23 publications

Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus

Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus

G protein-coupled receptors driven intestinal glucagon-like peptide-1 reprogramming for obesity: Hope or hype?

Capsaicin has an anti-obesity effect through alterations in gut microbiota populations and short-chain fatty acid concentrations

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