The improvement of corrosion resistance, biocompatibility and osteogenesis of the novel porous Mg–Nd–Zn alloy

Liu, Wei; Wang, Jiaxing; Jiang, Guofeng; Guo, Jinxiao; Li, Qiuyan; Li, Bin; Wang, Qiaojie; Cheng, Mengqi; He, Guo; Zhang, Xianlong

doi:10.1039/c7tb00920h

Cited by 27 publications

(16 citation statements)

References 46 publications

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“…114 Liu et al studied the live/dead cell assay, CCK-8 assay, cell morphology staining, alizarin red attaining, ALP assay, and osteogenic gene expression for detailed evaluation of the biocompatibility and osteogenesis of Mg-Nd-Zn alloy. 115 Gai et al applies xCELLigence real-time cell analysis (RTCA) method in combination with the MTT assay using L929, MG-63, and endothelial cell lines of the human umbilical cord vein to reveal the various dynamic modes of the cytotoxic process. 116 The cyanine dye assay (CyQUANT assay) may be the excellent alternative to the conventional MTT assay for the in vitro biocompatibility evaluation.…”

Section: Cell Culture and Assays (Cell Adhesion Morphology Proliferation Cytocompatibility And Alkaline Phosphatase Activity)mentioning

confidence: 99%

“…Zhang et al calculated the relative growth rate of mesenchymal stem cells from human bone marrow using the CCK‐8 assay 114 . Liu et al studied the live/dead cell assay, CCK‐8 assay, cell morphology staining, alizarin red attaining, ALP assay, and osteogenic gene expression for detailed evaluation of the biocompatibility and osteogenesis of Mg–Nd–Zn alloy 115 . Gai et al applies xCELLigence real‐time cell analysis (RTCA) method in combination with the MTT assay using L929, MG‐63, and endothelial cell lines of the human umbilical cord vein to reveal the various dynamic modes of the cytotoxic process 116 .…”

Section: In Vitro and In Vivo Assessmentsmentioning

confidence: 99%

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In vitro and in vivo degradation assessment and preventive measures of biodegradable Mg alloys for biomedical applications

Jana

Das

Balla

2021

J Biomedical Materials Res

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Magnesium (Mg) and its alloys have been widely explored as a potential biodegradable implant material. However, the fast degradation of Mg‐based alloys under physiological environment has hindered their widespread use for implant applications till date. The present review focuses on in vitro and in vivo degradation of biodegradable Mg alloys, and preventive measures for biomedical applications. Initially, the corrosion assessment approaches to predict the degradation behavior of Mg alloys are discussed along with the measures to control rapid corrosion. Furthermore, this review attempts to explore the correlation between in vitro and in vivo corrosion behavior of different Mg alloys. It was found that the corrosion depends on experimental conditions, materials and the results of different assessment procedures hardly matches with each other. It has been demonstrated the corrosion rate of magnesium can be tailored by alloying elements, surface treatments and heat treatments. Various researches also studied different biocompatible coatings such as dicalcium phosphate dihydrate (DCPD), β‐tricalcium phosphate (β‐TCP), hydroxyapatite (HA), polycaprolactone (PCL), polylactic acid (PLA), and so on, on Mg alloys to suppress rapid degradation and examine their influence on new bone regeneration as well. This review shows the need for a standard method of corrosion assessment to predict the in vivo corrosion rate based on in vitro data, and thus reducing the in vivo experimentation.

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Section: Cell Culture and Assays (Cell Adhesion Morphology Proliferation Cytocompatibility And Alkaline Phosphatase Activity)mentioning

confidence: 99%

Section: In Vitro and In Vivo Assessmentsmentioning

confidence: 99%

In vitro and in vivo degradation assessment and preventive measures of biodegradable Mg alloys for biomedical applications

Jana

Das

Balla

2021

J Biomedical Materials Res

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“…For example, the pH value of the as-cast Mg-x Cu (x = 0.1, 0.25 wt%) alloy immersion solution exceeded 9 after only 3 h of immersion in vitro ( Li et al, 2016b ). However, the pH value of the immersion solution of some alloys rises slowly, and it takes several days to reach an effective bacteriostatic pH ( Qin et al, 2015a ; He et al, 2015 ; Liu et al, 2017b ). The zinc-containing Mg-Ca-Sr alloy reported by He et al did not reach a pH value of 10 until 5 days of immersion ( He et al, 2015 ).…”

Section: Antibacterial Mechanism Of Mg- Zn- and Fe-based Alloys As Or...mentioning

confidence: 99%

Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials

Wang

Shi

et al. 2022

Front. Bioeng. Biotechnol.

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Implant-associated infection (IAI) is one of the major challenges in orthopedic surgery. The development of implants with inherent antibacterial properties is an effective strategy to resolve this issue. In recent years, biodegradable alloy materials have received considerable attention because of their superior comprehensive performance in the field of orthopedic implants. Studies on biodegradable alloy orthopedic implants with antibacterial properties have gradually increased. This review summarizes the recent advances in biodegradable magnesium- (Mg-), iron- (Fe-), and zinc- (Zn-) based alloys with antibacterial properties as orthopedic implant materials. The antibacterial mechanisms of these alloy materials are also outlined, thus providing more basis and insights on the design and application of biodegradable alloys with antibacterial properties as orthopedic implants.

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“…The addition of Nd shows a solid solution strengthening effect and then reduces the potential difference, which would eventually improve the corrosion resistance of magnesium alloys. 135,136 Research suggests that Y element shows solid solution effect on magnesium alloys due to its high solubility in magnesium. 137 Nd in the WE43 magnesium alloy elevates the mechanical properties mainly by grain boundary strengthening, due to the formation of the intermetallic phase in the grain boundary.…”

Section: Microstructure and Mechanical Propertiesmentioning

confidence: 99%

Degradable magnesium-based alloys for biomedical applications: The role of critical alloying elements

Yang

Dou

et al. 2019

J Biomater Appl

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Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing process. Alloying is an effective method to slow down the corrosion rate. However, currently magnesium alloys used as biomaterials are mostly commercial alloys without considering cytotoxicity from the perspective of biosafety. This article comprehensively reviews the status of various existing and newly developed degradable magnesium-based alloys specially designed for biomedical application. The effects of critical alloying elements, compositions, heat treatment and processing technology on the microstructure, mechanical properties and corrosion resistance of magnesium alloys are discussed in detail. This article covers Mg–Ca based, Mg–Zn based, Mg–Sr based, Mg–RE based and Mg–Cu-based alloy systems. The novel methods of fabricating Mg-based biomaterials and surface treatment on Mg based alloys for potential biomedical applications are summarized.

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The improvement of corrosion resistance, biocompatibility and osteogenesis of the novel porous Mg–Nd–Zn alloy

Abstract: A magnesium scaffold is a promising biodegradable bone repair material.

Cited by 27 publications

References 46 publications

In vitro and in vivo degradation assessment and preventive measures of biodegradable Mg alloys for biomedical applications

In vitro and in vivo degradation assessment and preventive measures of biodegradable Mg alloys for biomedical applications

Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials

Degradable magnesium-based alloys for biomedical applications: The role of critical alloying elements

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