Encryption of data is fundamental to secure communication in the modern world. Beyond encryption of data lies obfuscation, i.e., encryption of functionality. It is well-known that the most powerful means of obfuscating classical programs, so-called "black-box obfuscation," is provably impossible [6]. For years since, obfuscation was believed to always be either impossible or useless, depending on the particulars of its formal definition. However, several recent results have yielded candidate schemes that satisfy a definition weaker than black-box, and yet still have numerous applications.In this work, we initialize the rigorous study of obfuscating programs via quantum-mechanical means. We define notions of quantum obfuscation which encompass several natural variants. The input to the obfuscator can describe classical or quantum functionality, and the output can be a circuit description or a quantum state. The obfuscator can also satisfy one of a number of obfuscation conditions: black-box, information-theoretic black-box, indistinguishability, and best-possible; the last two conditions come in three variants: perfect, statistical, and computational. We discuss a number of applications, including CPA-secure quantum encryption, quantum fully-homomorphic encryption, and public-key quantum money. We then prove several impossibility results, extending a number of foundational papers on classical obfuscation to the quantum setting. We prove that quantum black-box obfuscation is impossible in a setting where adversaries can possess more than one output of the obfuscator (possibly even on the same input.) In particular, generic transformation of quantum circuits into black-box-obfuscated quantum circuits is impossible. We also show that statistical indistinguishability obfuscation is impossible, up to an unlikely complexity-theoretic collapse. Our proofs involve a new tool: chosen-ciphertext-secure encryption of quantum data, which was recently shown to be possible provided that quantum-secure one-way functions exist [5].We emphasize that our results leave open one intriguing possibility: black-box obfuscation of classical or quantum circuits into a single, uncloneable quantum state. This indicates that, in spite of our results, quantum obfuscation may be significantly more powerful than its classical counterpart.