The Importance of Vitamin K and the Vitamins K and D Combined for the Calcium Metabolism and Bone Health: A Review
Jan O. Aaseth,
Trine Elisabeth Finnes,
Merete Askim
et al.
Abstract:The aim of the present review is to discuss the roles of vitamin K and vitamin K-dependent proteins, and the combined action of the vitamins K and D, for maintenance of bone health. The most relevant vitamin K-dependent proteins in this respect are osteocalcin and matrix Gla-protein (MGP). When carboxylated these proteins appear to have the ability to chelate and import calcium from the blood to the bone, thereby reducing the risk of osteoporosis. Carboxylated osteocalcin appears to contribute directly to bone… Show more
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