The importance of visual function in the quality of life of children with uveitis

Angeles‐Han, Sheila T.; Griffin, Kenneth W.; Lehman, Thomas A.; Rutledge, John; Lyman, Stephen; Nguyen, Joseph; Harrison, Melanie

doi:10.1016/j.jaapos.2009.12.160

Cited by 42 publications

(38 citation statements)

References 28 publications

(22 reference statements)

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“…The Effects of Youngsters’ Eyesight on Quality of Life (EYE-Q)83 84 is interchangeably referred to as a measure of visual function and QoL. Tables 2 and 3 provide details of the comparison of intended and achieved measured constructs and/or domains targeted by these instruments.…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, we found that some investigators appear to assume that vision- or eye condition-related QoL involves measurement of the restriction in eye or vision function. Thus, certain measures apparently assessing vision- or eye condition-specific QoL in fact comprise scales assessing symptoms or functional ability associated with those conditions (eg, QUICK43 and EYE_Q83 84). …”

Section: Discussionmentioning

confidence: 99%

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Patient-reported outcome measures (PROMs) in paediatric ophthalmology: a systematic review

et al. 2013

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198/200; Main text 4099/4000. Refs 85; Tables 1; Figures 1; Appendices 7. 2 CHESS PROMs review Cephalgia FTC:110117 Re-submit 240517 Tables edited 270717 Structured Abstract: (198/200) Aims To critically appraise, compare and synthesise the quality and acceptability of multi-item PROMs for adults with chronic or episodic headache. Methods Systematic literature searches of major databases (1980-2016) to identify published evidence of PROM measurement and practical properties. Data on study quality (COSMIN), measurement and practical properties per measure was extracted and assessed against accepted standards to inform an evidence synthesis. Results From 10,903 reviewed abstracts, 103 articles were assessed in full; 46 provided evidence for 23 PROMs: eleven specific to the health-related impact of migraine (n=5) or headache (n=6); six assessed migraine-specific treatment response/satisfaction; six were generic measures. Evidence for measurement validity and score interpretation was strongest for two measures of impact-Migraine-Specific Quality of Life Questionnaire (MSQ v2.1) and Headache Impact Test 6-item (HIT-6), and one of treatment response-the Patient Perception of Migraine Questionnaire (PPMQ-R). Evidence of reliability was limited, but acceptable for the HIT-6. Responsiveness was rarely evaluated. Evidence for the remaining measures was limited. Patient involvement was limited and poorly reported. Conclusion Whilst evidence is limited, three measures have acceptable evidence of reliability and validity-HIT-6, MSQ v2.1 and PPMQ-R. Only the HIT-6 has acceptable evidence supporting its completion by all 'headache' populations.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Patient-reported outcome measures (PROMs) in paediatric ophthalmology: a systematic review

et al. 2013

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“…The clinical ocular exam (i.e. slit lamp exam or visual acuity), and other validated subjected measures such as the Pediatric Quality of Life Inventory (PedsQL) to measure overall QOL, or the Effects of Youngsters’ Eyesight on Quality of Life (EYE-Q) to measure visual function and vision related QOL could be considered but may be difficult to implement in such a large cohort since they are time consuming to administer 48,49 .…”

Section: Discussionmentioning

confidence: 99%

Risk Markers of Juvenile Idiopathic Arthritis-associated Uveitis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry

et al. 2013

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OBJECTIVES To characterize the epidemiology and clinical course of children with juvenile idiopathic arthritis-associated uveitis (JIA-U) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and explore differences between African American (AA) and Non-Hispanic White (NHW) children. METHODS There were 3,967 NHW and AA children with JIA enrolled in the CARRA Registry. Demographic and disease-related data were collected from time of diagnosis to enrollment. Children with JIA alone were compared to those with JIA-U. Children with JIA-U were then compared by race. RESULTS Mean age of children with JIA-U was 11.4 years (±4.5), 76.9% were female and 2.8% were AA. Children with JIA-U were younger at arthritis onset, female, required more medications, had <5 joints involved, had oligoarticular JIA, and ANA (+), RF (−) and anti-CCP (−). AA children with JIA-U had decreased uveitis frequency, were older at arthritis onset and more frequently diagnosed with enthesitis-related JIA. Predictors of uveitis development include female gender, early age of arthritis onset, and oligoarticular persistent and extended JIA classification, whereas polyarticular RF-positive JIA was protective. CONCLUSIONS The prevalence of JIA-U in AA and NHW children is 11.6% in the CARRA registry. Known risk markers (ANA, age at arthritis onset, and oligoarticular JIA) were more frequent in our JIA-U cohort. AA children had a lower frequency of JIA-U. There were significant differences in age of arthritis onset and JIA subtype between NHW and AA children, although the ANA, RF and HLA-B27 were similar. Exploration of race as a risk factor should be considered.

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“…However, an assessment tool to measure vision-related quality of life in children was developed only recently, in 2010. The Effects of Youngsters' Eyesight on Quality of Life (EYE-Q) 36 questionnaire was initially validated in a population of 120 children aged 8-18 years with JIA-associated uveitis, of whom 46.7% had no visual impairment and 52% had bilateral eye involvement. 37 At this stage, however, further validation and adaptation for different countries is required before this uveitis-related quality of life tool can be widely adopted.…”

Section: Initial Screeningmentioning

confidence: 99%

Uveitis associated with juvenile idiopathic arthritis

Sen¹,

Dick²,

Ramanan³

2015

Nat Rev Rheumatol

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Uveitis is a potentially sight-threatening complication of juvenile idiopathic arthritis (JIA). JIA-associated uveitis is recognized to have an autoimmune aetiology characterized by activation of CD4(+) T cells, but the underlying mechanisms might overlap with those of autoinflammatory conditions involving activation of innate immunity. As no animal model recapitulates all the features of JIA-associated uveitis, questions remain regarding its pathogenesis. The most common form of JIA-associated uveitis is chronic anterior uveitis, which is usually asymptomatic initially. Effective screening is, therefore, essential to detect early disease and commence treatment before the development of visually disabling complications, such as cataracts, glaucoma, band keratopathy and cystoid macular oedema. Complications can result from uncontrolled intraocular inflammation as well as from its treatment, particularly prolonged use of high-dose topical corticosteroids. Accumulating evidence supports the early introduction of systemic immunosuppressive drugs, such as methotrexate, as steroid-sparing agents. Prospective randomized controlled trials of TNF inhibitors and other biologic therapies are underway or planned. Future research should aim to identify biomarkers to predict which children are at high risk of developing JIA-associated uveitis or have a poor prognosis. Such biomarkers could help to ensure that patients receive earlier interventions and more-potent therapy, with the ultimate aim of reducing loss of vision and ocular morbidity.

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The importance of visual function in the quality of life of children with uveitis

Cited by 42 publications

References 28 publications

Patient-reported outcome measures (PROMs) in paediatric ophthalmology: a systematic review

Patient-reported outcome measures (PROMs) in paediatric ophthalmology: a systematic review

Risk Markers of Juvenile Idiopathic Arthritis-associated Uveitis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry

Uveitis associated with juvenile idiopathic arthritis

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