The importance of urine 5-hydroxyindoleacetic acid levels in the early diagnosis of acute appendicitis

Menteş, Öner; Eryılmaz, Mehmet; Harlak, Ali; Yaman, Halıl; Yiğit, Taner; Ongoru, Onder; Balkan, Müjdat; Kozak, Orhan; Tufan, Turgut

doi:10.1016/j.ajem.2008.03.016

Cited by 13 publications

(10 citation statements)

References 10 publications

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“…Acute appendicitis is the most common cause of acute abdominal surgery, and morbidity and mortality in AA significantly decrease in the event of early diagnosis (6). Mortality has decreased by 85% and operation rates have decreased by 63% with developments in the diagnosis and treatment of AA, whereas discharge rates of patients with abdominal pain have increased by 88% (16).…”

Section: Discussionmentioning

confidence: 99%

“…In recent studies, RDW was claimed to be useful for the detection of a risk of mortality in patients that have cardiovascular disease, acute dyspnea, acute pancreatitis, community-acquired pneumonia, and sepsis (2)(3)(4)(5). Acute appendicitis (AA) is the most common cause of acute abdominal pain that requires an emergency surgical operation in adults (6). Individuals have a 7% risk of AA over the course of a lifetime (7).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Use of Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis

Ertekin¹,

Kara²,

Erdemir³

et al. 2017

EAJEM

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of Use of Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis

Ertekin¹,

Kara²,

Erdemir³

et al. 2017

EAJEM

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“…Higher serotonin levels in the blood and increased excretion of 5-Hydroxy indoleacetic acid (5-HIAA) in the urine of patients with acute appendicitis seem to be well documented. [5][6][7][8] Most of these papers assume that the increase of serotonin or its metabolites is due to the degranulation of EC cells found in the appendix.…”

Section: Discussionmentioning

confidence: 99%

Enterochromaffin Cells and Mast Cells in Acute Appendicitis

Mohan

Aravindan

2020

J Lab Physicians

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Background and Objective Serotonin levels are increased in acute appendicitis. We investigated the possible source of this increase. The aim of this study was to compare the distribution and density of epithelial and nonepithelial enterochromaffin (EC) cells as well as numbers of degranulated and nondegranulated mast cells in different layers of normal appendices and acute appendicitis. Methods Sections from 15 cases of acute appendicitis and 10 cases where the appendix was morphologically normal were stained with Hematoxylin & Eosin, Toluidine blue, and immunohistochemically for chromogranin and CD-117. EC cells stained by chromogranin were counted per crypt and extraepithelial EC cells counted and expressed as cells per unit area (mm2). Mast cells stained by Toluidine blue and CD-117 were counted in lamina propria, submucosa, and muscle layers. The difference between Toluidine blue and CD117 stained mast cells was taken to be an estimate of degranulated cells. The cell counts were expressed per unit area (mm2) as well as per cross-sectional area of the appendix. Results There was no statistically significant difference in epithelial and extraepithelial EC cells between acute appendicitis and normal appendix. Estimated mast cell degranulation as indicated by mast cell counts per cross-sectional area is greatly increased in acute appendicitis when compared with normal. Conclusion Degranulated mast cells rather than EC cells may be the main source of raised serotonin in acute appendicitis.

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“…In vitro studies have shown that there is a correlation between high 5-HIAA levels and appendiceal inflammation 3 14. However, the results of studies on adults, are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…The sample size was determined according to sample sizes from previously published studies 7 14. Moreover, the sample size calculated using MedCalc for an area under the receiver operating characteristic (ROC) curve (AUC) of 0.9037 15 (ά=0.005, β=0.2) and null hypothesis value of 0.8 was lower (61 participants per test and control group) than our initially defined sample.…”

Section: Methodsmentioning

confidence: 99%

Does elevated urinary 5-hydroxyindole acetic acid level predict acute appendicitis in children?

et al. 2016

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The importance of urine 5-hydroxyindoleacetic acid levels in the early diagnosis of acute appendicitis

Cited by 13 publications

References 10 publications

Efficacy of Use of Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis

Efficacy of Use of Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis

Enterochromaffin Cells and Mast Cells in Acute Appendicitis

Does elevated urinary 5-hydroxyindole acetic acid level predict acute appendicitis in children?

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