The importance of timing on the respiratory effects of intermittent carotid sinus nerve stimulation

Eldridge, Frederíc L.

doi:10.1113/jphysiol.1972.sp009798

Cited by 71 publications

(24 citation statements)

References 30 publications

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“…The central respiratory neurons are able to rectify the carotid chemoreceptor afferent information since inspiratory and expiratory volume effects depend on the time in different respiratory cycles in that brief stimulation of the carotid chemoreceptors or electrical stimulation of the CSN occurs (ELDRIDGE, 1972a(ELDRIDGE, , b, 1976. ELDRIDGE (1976) found that stimulation of carotid chemoreceptor afferents given only during expiration produced the prolongation of TE accompanied by an increase in IIMA.…”

Section: Discussionmentioning

confidence: 99%

Effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity in the rabbit.

Matsumoto

1986

Jpn.J.Physiol

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The effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity (IIMA) were studied before and after surgical denervation of the carotid sinus nerve (CSN) in the rabbit. An intracarotid injection of 30 µg of sodium cyanide (NaCN) during inspiration caused an increase in both IIMA and respiratory rate (RR). In contrast, intracarotid administration of 10 µg of dopamine (DA) during inspiration resulted in a decrease in both IIMA and RR. The NaCN-and DA-induced characteristic responses in IIMA were abolished by the section of the CSN. The results indicate that the excitatory and inhibitory responses of IIMA to intracarotid injections of NaCN and DA are mainly mediated through carotid chemoreflexes.

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Section: Discussionmentioning

confidence: 99%

Effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity in the rabbit.

Matsumoto

1986

Jpn.J.Physiol

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“…This differential effect can be shown easily with electrical stimulation of the carotid sinus nerve (Black & Torrance, 1967; Howard, Bromberger-Barnea, Fitzgerald & Bane, 1969). In the preceding report (Eldridge, 1972) it was shown that intermittent electrical stimulation led to a rapid effect on tidal volume and phrenic activity, but only if given in inspiration; and that increases in tidal volume or peak phrenic activity occurred only if the stimulation were given in the last half of inspiration. The timing of chemical stimulation of the carotid body similarly has been shown to be important (Black & Torrance, 1967;Bernards & Sistermans, 1969;Band, Cameron & Semple, 1970), but these studies did not show detailed relationships.…”

Section: Introductionmentioning

confidence: 96%

“…The Experiments were carried out in two groups of animals. In both groups equipment and methods used in measurement were otherwise the same as those described in the preceding report (Eldridge, 1972 (Eldridge, 1971 (Fig. 3).…”

Section: Introductionmentioning

confidence: 99%

The importance of timing on the respiratory effects of intermittent carotid body chemoreceptor stimulation

Eldridge¹

1972

The Journal of Physiology

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104

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“…Presentation of the stimuli in the reverse manner -an increase to chemoreceptors and a reduction in vagal stimulation -also produced similar effects on the pattern of breathing. For example, qualitatively similar responses were produced either by excitation of carotid sinus nerve activity by electrical or chemical stimuli for 01 see (Eldridge, 1972), or by a reduction in the frequency of vagal stimulation from values in the range 40-100 Hz down to 10 Hz for 0.1 sec. It can therefore be concluded that increased activity from carotid chemoreceptors and pulmonary stretch receptors have opposing central effects on breathing -one excitatory and the other inhibitorypossibly at the same site in the respiratory centre.…”

Section: Pmentioning

confidence: 89%

Communications

1979

The Journal of Physiology

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EH8 9JZIn the pentobarbitone-anaesthetized cat, exogenous dopamine causes inhibition of carotid chemoreceptor activity sometimes followed by a period of stimulation and it has been suggested that endogenous dopamine may modulate chemoreceptor activity (Docherty & McQueen, 1978).In the present study the effects of benztropine, a dopamine uptake blocker, and pargyline, a monoamine oxidase inhibitor, on the chemoreceptor response to NaCN, ACh and dopamine were investigated. Chemoreceptor activity was recorded and quantified as previously described (McQueen, 1977) and drugs injected into the ipsilateral carotid artery. Benztropine (0.25-0.50 mg/kg I.A.) and pargyline (2-5-50 mg/kg I.A.) both augmented dopamineinduced inhibition of chemoreceptor activity and potentiated responses to NaCN (Fig. 1), benztropine being more effective than pargyline. Responses to ACh were unchanged by pargyline or benztropine.It is difficult to estimate the influence of non-specific actions of benztropine or pargyline in these preliminary experiments, but the finding that drugs which augment the inhibitory effects of exogenous dopamine potentiate the response to NaCN suggests that endogenous dopamine may have an excitatory effect on carotid chemosensory activity in the cat.

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The importance of timing on the respiratory effects of intermittent carotid sinus nerve stimulation

Cited by 71 publications

References 30 publications

Effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity in the rabbit.

Effects of carotid chemoreceptor stimulating and depressing agents on internal intercostal muscle activity in the rabbit.

The importance of timing on the respiratory effects of intermittent carotid body chemoreceptor stimulation

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