The importance of timing in surgical treatment of unruptured symptomatic aneurysm of abdominal aorta

Pasternak, Janko; Nikolić, Dragan; Popović, Vladan; Vucaj-Cirilovic, Viktorija

doi:10.4149/bll_2012_147

Cited by 3 publications

(8 citation statements)

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“…The average age of our patients was 71.6 years; the oldest patient was 93 and the youngest 55 years of age. These data support the fact that aneurysm is a disease affecting the elderly population, mostly in the seventh decade, which was also confirmed by other available studies [9,25].…”

Section: Discussionsupporting

confidence: 90%

“…Nicotinism, although a very widespread comorbidity, was present only in 25.56% of patients. The results obtained are very similar to the results in the literature [9] with differences in response; DM 3% and nicotinism 67%, were much more prevalent in their patients. Thompson et al [27] have come to the conclusion that HTA occurs more frequently in patients with rAAA versus sAAA in patients over 65 years of age, while in our sample there were more patients with HTA in those with sAAA.…”

Section: Discussionsupporting

confidence: 89%

“…A sAAA was diagnosed in 45 patients, while the remaining 88 had a rAAA, which is similar to the data available in the literature [9].…”

Section: Discussionsupporting

confidence: 86%

“…The male to female ratio among the investigated patients was 6 : 1, similar to the distribution found in the literature [9] of 7 : 1; this difference can be explained by the fact that the sample included almost three times more patients. Although the sample was much larger, in both studies the analyzed patients were most- ly 60 years of age: in our case 87% while in the other study 79% [9]. The average age of our patients was 71.6 years; the oldest patient was 93 and the youngest 55 years of age.…”

Section: Discussionsupporting

confidence: 85%

“…According to the clinical presentation, AAAs may be divided into two groups: asymptomatic AAA and symptomatic AAA (sAAA). Symptomatic aneurysms can be further divided into ruptured and non-ruptured aneurysms [9].…”

Section: Introductionmentioning

confidence: 99%

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Significance of delayed surgical treatment of symptomatic non-ruptured abdominal aortic aneurysm

et al. 2019

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Introduction. An abdominal aortic aneurysm is a permanent focal dilation of the blood vessel wall to about 1.5 times larger than the normal diameter. Clinically, it may be divided into symptomatic and asymptomatic. It is still discussed whether patients with symptomatic non-ruptured abdominal aortic aneurysm benefit more from emergency or delayed surgical treatment. The aim of the study was to evaluate the results of the symptomatic non-ruptured aneurysms in regard to the diameter of ruptured and non-ruptured symptomatic aneurysms and the impact of the time elapsed from admission to surgery on its outcome. Material and Methods. The retrospective study included all 133 patients who underwent surgery due to symptomatic non-ruptured or ruptured abdominal aortic aneurysm at the Clinic of Vascular and Endovascular Surgery during the previous 3 years. Results. Out of a total of 133 patients, 75.19% underwent surgery in the first 24 hours after admission, while the rest 24.81% of patients were operated later. Intraoperative complications were recorded only in patients with ruptured aneurysms, 4% had cardiac arrest and 1.5% of patients had fatal outcome. The inhospital mortality was 16.67% in patients with non-ruptured aneurysm of the abdominal aorta operated in the first 24 hours, and 9.91% in patients who were operated after 24 hours after admission. Conclusion. Early elective surgery is a method of choice in the treatment of symptomatic non-ruptured aneurysm of the abdominal aorta. However, surgical treatment in the first 24 hours is associated with a higher mortality rate than surgery after 24 hours after admission. Also, there is no statistically significant difference in the diameter of ruptured and non-ruptured symptomatic aneurysms, but the average size of the aneurysm diameter is higher in ruptured than in non-ruptured aneurysms, which confirms the fact that the increase in diameter increases the risk of aneurysm rupture.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

“…A sAAA was diagnosed in 45 patients, while the remaining 88 had a rAAA, which is similar to the data available in the literature [9].…”

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Significance of delayed surgical treatment of symptomatic non-ruptured abdominal aortic aneurysm

et al. 2019

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Results of Surgical Treatment of Patients with Symptomatic Abdominal Aortic Aneurysms

Mikhailov,

Isayev,

Kokov

et al. 2024

Neotložnaâ med. pomoŝʹ

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Relevance Abdominal aortic aneurysm is a common disease, manifested by an expansion of the abdominal aorta of more than 3 cm and accompanied by the development of serious complications with high mortality. There are symptomatic aneurysms, asymptomatic aneurysms and ruptured aneurysms. The timing of surgical intervention for symptomatic aneurysms still causes some controversy.Aim of study To determine the tactics and timing of surgery in patients with symptomatic abdominal aortic aneurysms.Material and methods The medical histories of 188 patients with symptomatic abdominal aortic aneurysms admitted to the Department of Vascular Surgery of N.V. Sklifosovsky Research Institute for Emergency Medicine. There were 152 men (80.8%) and 36 women (19.2%). The average age of those admitted was 69.8±2.5 years (from 53 to 84 years).Results All patients were divided into three groups, depending on the time of operation from the moment of admission: those operated in the first 24 hours (n=27); those operated from 24 to 72 hours from the moment of admission (n=20) and those operated later than 72 hours (n=136). The mortality by group was 14.8% in the first group, 20.0% in the second group, 7.3%in the third group.Conclusions Patients with symptomatic abdominal aortic aneurysm should be admitted to the intensive care unit for evaluation and preparation for delayed surgery. In cases where hospitalization in the intensive care unit is impossible or pain persists, the patient should be operated on urgently. When the pain syndrome is relieved and blood pressure is normalized, the patient can be further examined and operated on in a delayed manner.

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Methylation of MMP2, TIMP2, MMP9 and TIMP1 in abdominal aortic aneurysm

Skorvanova¹,

Matáková²,

Škereňová³

et al. 2020

BLL

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OBJECTIVES: Abdominal aortic aneurysm (AAA) and its complications are among the most serious cardiovascular diseases and its occurrence has risen sharply in recent years. The aim of this pilot study is to explore the relationship between the methylation of matrix metalloproteinases and tissue inhibitors of the metalloproteinases genes' promoter region, and abdominal aortic aneurysm (AAA) through the detection of the methylation status of MMP2, TIMP2, TIMP1, and MMP9 genes in peripheral blood. METHODS: The study included 43 males with verifi ed AAA (case group) and 34 healthy males (control group). The methylation status of the genes' promoter region was detected by methylation-specifi c polymerase chain reaction (MS-PCR). RESULTS: In adominal aortic aneurysm patients, the methylation ratio of MMP2 gene was positive in 9.3 % (4 cases), 2.3 % (1 case) had methylated TIMP2 gene, 7.0 % (3 cases) had methylated TIMP1 gene, while the methylation ratio of MMP9 gene was positive in 93.0 % (40 cases). In the control group, MMP2 gene was found to be methylated in 5.9 % (2 cases), 5.9 % of cases had methylated TIMP2 and TIMP1 genes (2 cases), and MMP9 gene was found to be methylated in 91.2 % (31 cases). CONCLUSION: In our pilot study, we found no association between DNA methylation of gelatinases and their tissue inhibitors, and the development of an abdominal aortic aneurysm (Tab. 2, Fig. 1, Ref. 27).

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The importance of timing in surgical treatment of unruptured symptomatic aneurysm of abdominal aorta

Cited by 3 publications

References 0 publications

Significance of delayed surgical treatment of symptomatic non-ruptured abdominal aortic aneurysm

Significance of delayed surgical treatment of symptomatic non-ruptured abdominal aortic aneurysm

Results of Surgical Treatment of Patients with Symptomatic Abdominal Aortic Aneurysms

Methylation of MMP2, TIMP2, MMP9 and TIMP1 in abdominal aortic aneurysm

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