The importance of the study of lactoferrin and soluble antigen of leukocytes -2 in human breast milk for prediction of hypogalactia

Abstract

¹ Российский университет дружбы народов, москва, Российская Федерация ² Ивановский научно-исследовательский институт материнства и детства им. В. Н. Городкова, Иваново, Российская Федерация МЕДИЦИНСКИЙ ВЕСТНИК СЕВЕРНОГО КАВКАЗА 2020. Т. 15. № 3 Medical news of north caucasus 2020. Vоl. 15. Iss. 3 Ключевые слова: шейка матки, дисплазия, иммуногистохимия, маркер пролиферации, Ki-67, p16 INK4a , Cyclin D1 The expression of proliferation markers (Ki-67, CyclinD1, p16 INK4a) in healthy tissue of the cervix, cervical intraepithelial neoplasias of grades 1-3 and carcinoma in situ in 110 HPV-positive women was studied immunohistochemically. It was noted that the severity of expression of proliferation markers was associated with the severity of dysplastic changes in the cervical tissue. The established quantitative values of markers for each variant of neoplasia are an additional tool for screening and clarifying the diagnosis in this group of patients.