The importance of the resection margin in conservative surgery for breast cancer

Renton, Sandra; Gazet, J.‐C.; Ford, H. T.; Corbishley, C.; Sutcliffe, R.

doi:10.1016/s0748-7983(96)91253-6

Cited by 148 publications

(57 citation statements)

References 28 publications

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“…In our study, local relapse occurred in 40 patients (5.7%), which is similar to other studies that have reported a 5-15% rate of local recurrence (Fisher et al, 1995;Clark et al, 1996;Forrest et al, 1996;Renton et al, 1996). However, this result is slightly greater than other Asian series (2.5-4%) (Kim et al, 2005;Yau et al, 2007;.…”

Section: Discussionsupporting

confidence: 90%

HER2-enriched Tumors Have the Highest Risk of Local Recurrence in Chinese Patients Treated with Breast Conservation Therapy

Jia

Jia²,

Feng³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 90%

HER2-enriched Tumors Have the Highest Risk of Local Recurrence in Chinese Patients Treated with Breast Conservation Therapy

Jia

Jia²,

Feng³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…4,10,[12][13][14][15][16][17][18][19] The trials vary with regard to patient selection, the extent of surgery and radiotherapy, and the use of adjuvant systemic therapy. Quadrantectomy was employed in the Milan and Swedish studies, and adjuvant chemotherapy and/or tamoxifen was used in the NSABP, Milan, British, Scottish, and West Midlands trials.…”

Section: Prospective Randomized Trialsmentioning

confidence: 99%

Standard for Breast Conservation Therapy in the Management of Invasive Breast Carcinoma

Morrow

Strom

Bassett

et al. 2002

CA: A Cancer Journal for Clinicians

298

166

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Multidisciplinary guidelines for management of invasive breast carcinoma from the American College of Radiology, the American College of Surgeons, the College of American Pathology, and the Society of Surgical Oncology have been updated to reflect the continuing advances in the diagnosis and treatment of invasive breast cancer. The guidelines provide a framework for clinical decision‐making for patients with invasive breast carcinoma based on review of relevant literature and include information on patient selection and evaluation, technical aspects of surgical treatment, techniques of irradiation, and follow‐up care.

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“…Several randomized studies (Clark et al, 1992;Veronesi et al, 1993;Liljegren et al, 1994;Fisher et al, 1995;Veronesi et al, 1995;Forrest et al, 1996;Liljegren et al, 1996;Renton et al 1996) and a meta-analysis (Early Breast Cancer Trialists Collaborative Group, 1995) have concluded that lumpectomy or quadrantectomy result in survival rates similar to those in mastectomy in stage I and II breast cancer, provided that adequate postoperative breast irradiation using modern radiotherapy techniques is given subsequent to breast preserving surgery. The main objective for postoperative radiotherapy is to reduce the rate of locoregional recurrences.…”

mentioning

confidence: 99%

“…The rate of ipsilateral breast recurrences has been reported to vary between 9% and 35% in patients not receiving postoperative irradiation after breast-preserving surgery. Postoperative radiation reduces the local recurrence rate to about one third (Kurtz et al, 1989;Clark et al, 1992;van Dongen et al, 1992, Veronesi et al, 1993Liljegren et al, 1994;Early Breast Cancer Trialists Collaborative Group, 1995;Fisher et al, 1995;Veronesi et al, 1995;Forrest et al, 1996;Liljegren et al, 1996;Renton et al 1996), and it has reduced the risk of recurrence after breast-preserving surgery in randomized studies regardless of whether tumours 2 cm or smaller (Liljegren et al, 1999), tumours smaller than 2.5 cm (Veronesi et al, 1993), or 4 cm or smaller in diameter (Clark et al, 1992;Fisher et al, 1995;Forrest et al, 1996) had been accrued, and regardless of whether only invasive or purely intraductal cancers were included in the studies (Fisher et al, 1998).…”

mentioning

confidence: 99%

Lumpectomy with or without postoperative radiotherapy for breast cancer with favourable prognostic features: results of a randomized study

et al. 2001

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SummaryThe aim of this trial was to study the value of adding post-operative radiotherapy to lumpectomy in a subgroup of breast cancer patients with favourable patient-, tumour-, and treatment-related prognostic features. 152 women aged over 40 with unifocal breast cancer seen in preoperative mammography were randomly assigned to lumpectomy alone (no-XRT group) or to lumpectomy followed by radiotherapy to the ipsilateral breast (50 Gy given within 5 weeks, XRT group). All cancers were required to be invasive node-negative, smaller than 2 cm in diameter and well or moderately differentiated, to contain no extensive intraductal component, to be progesterone receptor-positive, DNA diploid, have S-phase fraction ≤7 and be excised with at least 1 cm margin. During a mean follow-up time of 6.7 years, 13 (18.1%) cancers recurred locally in the no-XRT and 6 (7.5%) in the XRT group (P = 0.03). There was no difference between the groups in the ultimate breast preservation rate (95.0% vs. 94.4% in XRT and no-XRT, respectively, P = 0.88), distant metastasis-free survival (P = 0.36), or 5-year cancer-specific survival (97.1% in XRT and 98.6 in no-XRT). Radiation therapy given after lumpectomy reduces the frequency of ipsilateral breast recurrences even in women with small breast cancer with several favourable clinical and biological features. However, the breast preservation rate may not increase due to more frequent use of salvage mastectomies in patients treated with postoperative radiotherapy.

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The importance of the resection margin in conservative surgery for breast cancer

Cited by 148 publications

References 28 publications

HER2-enriched Tumors Have the Highest Risk of Local Recurrence in Chinese Patients Treated with Breast Conservation Therapy

HER2-enriched Tumors Have the Highest Risk of Local Recurrence in Chinese Patients Treated with Breast Conservation Therapy

Standard for Breast Conservation Therapy in the Management of Invasive Breast Carcinoma

Lumpectomy with or without postoperative radiotherapy for breast cancer with favourable prognostic features: results of a randomized study

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