The Importance of the Proportion of Heme/Nonheme Iron in the Diet To Minimize the Interference with Calcium, Phosphorus, and Magnesium Metabolism on Recovery from Nutritional Ferropenic Anemia

Abstract

The digestive utilization of Fe and its nutritive interaction with Ca, P, and Mg were studied in rats with nutritional ferropenic anemia. The diet contained 80% ferric citrate and 20% heme iron (80/20 diet). The weight gain, digestive utilization of Fe, and regeneration efficiency of hemoglobin and seric Fe were higher in iron-deficient rats (ID) fed the 80/20 diet than in iron-deficient rats fed the 50/50 diet (Campos et al., 1996). The phospho-calcic metabolism, which is adversely affected in ferropenic anemia, returned to normal values when iron was added to the diet. The digestive utilization of Mg, which fell with the 50/50 diet (Campos et al., 1996), returned to normal values when the ferropenic anemia was reversed with the 80/20 diet. In a state of iron deficiency, certain parameters related to the glucose and lipid metabolism are affected; the glucose and triglycerides values return to a normal range with the 80/20 diet.

Consumption of caprine milk improves metabolism of calcium and phosphorus in rats with nutritional ferropenic anaemia

“…At the same time, the absorption of P increases by about 21%, because of the greater absorption of Ca, as reported previously by Lisbona et al(1999). After feeding the rats the different Fe-normal diets (S, C or G), the ADC of Ca was found to be lower in the anaemic rats, with respect to their controls, and consequently the absorption (ADC) of P was lower, confirming the findings of Lisbona et al (1999). The lower ADC of Ca could have occurred because anaemia promotes an increase in the digestive utilization of Fe, thus diminishing that of Ca.…”

“…This greater digestive utilization of Ca in the anaemic rats than in the controls was expected, because the deficiency of a divalent cation, such as Fe, in the intestinal region produces an increase in the absorption of other divalent cations, such as Ca, according to Campos et al (1998). At the same time, the absorption of P increases by about 21%, because of the greater absorption of Ca, as reported previously by Lisbona et al(1999). After feeding the rats the different Fe-normal diets (S, C or G), the ADC of Ca was found to be lower in the anaemic rats, with respect to their controls, and consequently the absorption (ADC) of P was lower, confirming the findings of Lisbona et al (1999).…”

Effects of goats' or cows' milks on nutritive utilization of calcium and phosphorus in rats with intestinal resection

“…Thus, GM could play an important role in preventing Ca deficiency. With reference to the Ca content in the other organs studied (liver, spleen, kidney, heart, brain, testis), these were within the normal ranges described in the literature for this species (Lisbona et al 1999).…”

Influencia del tipo de proteína y la fuente de hierro en la dieta sobre la absorción de aminoácidos y minerales

“…Magnesium retention was also modified as a function of the iron source. Magnesium-based antacids have previously been shown to interfere with iron absorption (25).…”