BackgroundThe COVID-19 outbreak was declared pandemic by the WHO on 11 March 2020. For that reason, we gathered insight from frontline healthcare professionals (nurses) regarding their perceptions, awareness, and familiarity of COVID-19. MethodsBeing a novel outbreak, we opted for a qualitative research design. With the help of a self-constructed and validated interview guide, face-to-face interviews were conducted with nurses to gain an in-depth knowledge. All interviews were audio-taped, transcribed verbatim, and were then analyzed for thematic contents by the standard content analysis framework. ResultsThe saturation was reached at the 12th interview. Two more interviews were carried out to ensure the saturation achieved at the 12th interview. Thematic content analysis yielded four major themes. (1) Perceived knowledge, awareness, and severity of COVID-19, (2) perceived personal capability of handling and managing the COVID-19, (3) perceived organizational capability of handling and managing the COVID-19, and (4) barriers in handling and managing the COVID-19. ConclusionFindings of our study and reservations of our nurses’ highlight areas of concern and scheme of improvement in the effective management of the COVID-19. The respondents are faced with substantial difficulties and barriers in providing healthcare services to patients. We believe that the current study can help in planning policies and generating guidelines that can meet the healthcare needs of the society while managing the COVID-19 as well as for future pandemic outbreaks of the same nature.